Insights into the associative role of hypertension and angiotensin II receptor in lower urinary tract dysfunction

Shimizu, Shogo

doi:10.1038/s41440-024-01597-8

Cited by 1 publication

(3 citation statements)

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“… Possible mechanisms by which metabolic syndrome causes a shift from detrusor overactivity to detrusor underactivity with aging. This bladder drawing was reproduced from Shimizu et al ( 37 ). ).…”

Section: Discussionmentioning

confidence: 99%

Section: Hypertension and Detrusor Underactivitymentioning

confidence: 99%

“…Hypertension causes bladder dysfunction and atherosclerosis in bladder blood flow ( 35 , 36 , 37 , 38 , 39 ). Spontaneously hypertensive rats, a model of essential hypertension, exhibit bladder dysfunction or frequent urination, with an increased number of voids and decreased bladder blood flow ( 35 , 36 , 37 , 38 , 39 ). Moreover, our previous studies showed that aging (54 or 72-week-old) caused detrusor underactivity (increased postvoiding residual urine volume, elevated intercontraction interval, and decreased voiding efficiency), higher blood pressure, lower bladder blood flow, bladder hypertrophy, and bladder wall thickening in old spontaneously hypertensive rats than in young spontaneously hypertensive rats.…”

Section: Hypertension and Detrusor Underactivitymentioning

confidence: 99%

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Association of detrusor underactivity with aging and metabolic syndrome: suggestions from animal models

Shimizu

2024

J Smooth Muscle Res

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Detrusor underactivity, a condition in which the bladder muscle does not contract strongly or long enough to empty the bladder completely or within the normal time frame, is a common cause of lower urinary tract symptoms in older individuals of both sexes. Although aging is a known risk factor for detrusor underactivity, its pathophysiological mechanisms are not fully understood. Therefore, establishing animal models that closely mimic the pathophysiology of detrusor underactivity in humans is necessary to elucidate these mechanisms. Metabolic syndrome is a cluster of several risk factors, including obesity, hyperlipidemia, hyperglycemia, and hypertension, which are associated with the development of diabetes, cardiovascular disease, and lower urinary tract dysfunction in both sexes. Notably, bladder dysfunction resulting from detrusor underactivity is observed at an earlier age in animal models with diabetes mellitus than in those without. Recently, detrusor underactivity-like phenotypes have been observed at a relatively early age in animal models with metabolic syndrome, involving obesity, hyperlipidemia, and hypertension, compared with those without. Therefore, this review introduces the association of detrusor underactivity with aging and metabolic syndrome, as well as possible pathophysiological mechanisms for detrusor underactivity from reports of various animal models. Notably, metabolic syndrome may accelerate the onset of age-related detrusor underactivity, and further analysis of old animal models with metabolic syndrome may help elucidate the pathogenesis of detrusor underactivity in humans.

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Section: Discussionmentioning

confidence: 99%