The anemia of inflammatory disease in the dog I. The nature of the problem

Sideroblastic Anemia in 7 Dogs (1996-2002)

“…[1][2][3][4] Results of previous studies indicated that bone marrow from healthy dogs contains many sideroblasts, with 1 to 3 small punctate iron deposits. 6,7 However, sideroblasts with Ͼ3 granules or large granules were uncommon, and ringed sideroblasts were not observed. 6,7 Reports of dogs with sideroblastic anemia indicate that they had many sideroblasts with numerous large iron granules but had relatively few ringed sideroblasts.…”

“…6,7 However, sideroblasts with Ͼ3 granules or large granules were uncommon, and ringed sideroblasts were not observed. 6,7 Reports of dogs with sideroblastic anemia indicate that they had many sideroblasts with numerous large iron granules but had relatively few ringed sideroblasts. [1][2][3] Criteria used to diagnose primary acquired sideroblastic anemia in humans vary, but generally include the presence of abnormally large sideroblastic granules, Ͼ5 iron-containing granules in nucleated erythroid cells, and Ͼ10% ringed sideroblasts.…”

“…5,6 Many rubricytes and metarubricytes in normal adult dogs (mean 44.3%) contain 1-3 small siderotic granules. 7 In sideroblastic anemia, the iron deposits are present in mitochondria. 5 These can be observed in bone marrow aspirates stained by Wrights-Giemsa or Prussian blue as granules that are larger and more numerous than ''normal'' sideroblast granules.…”

Sequenciamento do RNAm codificante da hepcidina e análise de sua expressão gênica em diferentes tecidos de ovinos saudáveis

“…A determinação da concentração do ferro plasmático é outra metodologia que tem sido utilizada como indicador precoce de processos inflamatórios em ratos (Hershko et al, 1974), cães (Feldman et al, 1981), bovinos (Erskine e Bartlett, 1993), equinos (Borges et al, 2007) e humanos (Mattioli et al, 2002;Cunietti et al, 2004). A concentração do ferro plasmático ou sérico diminui rapidamente em resposta a inflamação nos seres vivos, sendo este teste um indicador confiável da presença do processo inflamatório em humanos e animais (Feldman et al, 1981;Cunietti et al, 2004;Jones e Alisson, 2007).…”

“…A concentração do ferro plasmático ou sérico diminui rapidamente em resposta a inflamação nos seres vivos, sendo este teste um indicador confiável da presença do processo inflamatório em humanos e animais (Feldman et al, 1981;Cunietti et al, 2004;Jones e Alisson, 2007).…”