The analysis of left atrial function predicts the severity of functional impairment in chronic heart failure: The FLASH multicenter study

Cameli, Matteo; Sciaccaluga, Carlotta; Loiacono, Ferdinando; Симова, Яна; Miglioranza, Marcelo Haertel; Nistor, Dan; Bandera, Francesco; Emdin, Michele; Giannoni, Alberto; Ciccone, Marco Matteo; Devito, Fiorella; Guaricci, Andrea Igoren; Favale, Stefano; Lisi, Matteo; Mandoli, Giulia Elena; Henein, Michael Y.; Mondillo, Sergio

doi:10.1016/j.ijcard.2019.03.063

Cited by 30 publications

(19 citation statements)

References 25 publications

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“…The importance of the assessment of LA function over LA size is becoming increasingly appropriate, not only for research purposes but also for everyday practice [11][12][13]. After the application of STE to other chambers than the LV, the additional role of LA deformation imaging has been explored in several clinical settings, mostly including conditions of atrial volume or pressure-volume overload e.g., heart valve diseases [14][15][16][17], AH [18,19], HF [20][21][22][23]. This led to the conclusion that a reduced LA longitudinal strain could be useful for the diagnosis, management and prognostic stratification in several conditions.…”

Section: Discussionmentioning

confidence: 99%

Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

Cameli

Miglioranza²,

Magné

et al. 2020

Diagnostics

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Two methods are currently available for left atrial (LA) strain measurement by speckle tracking echocardiography, with two different reference timings for starting the analysis: QRS (QRS-LASr) and P wave (P-LASr). The aim of MASCOT HIT study was to define which of the two was more reproducible, more feasible, and less time consuming. In 26 expert centers, LA strain was analyzed by two different echocardiographers (young vs senior) in a blinded fashion. The study population included: healthy subjects, patients with arterial hypertension or aortic stenosis (LA pressure overload, group 2) and patients with mitral regurgitation or heart failure (LA volume–pressure overload, group 3). Difference between the inter-correlation coefficient (ICC) by the two echocardiographers using the two techniques, feasibility and analysis time of both methods were analyzed. A total of 938 subjects were included: 309 controls, 333 patients in group 2, and 296 patients in group 3. The ICC was comparable between QRS-LASr (0.93) and P-LASr (0.90). The young echocardiographers calculated QRS-LASr in 90% of cases, the expert ones in 95%. The feasibility of P-LASr was 85% by young echocardiographers and 88% by senior ones. QRS-LASr young median time was 110 s (interquartile range, IR, 78-149) vs senior 110 s (IR 78-155); for P-LASr, 120 s (IR 80-165) and 120 s (IR 90-161), respectively. LA strain was feasible in the majority of patients with similar reproducibility for both methods. QRS complex guaranteed a slightly higher feasibility and a lower time wasting compared to the use of P wave as the reference.

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Section: Discussionmentioning

confidence: 99%

Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

Cameli

Miglioranza²,

Magné

et al. 2020

Diagnostics

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“…PALS has shown to be an accurate index of LV filling pressures, and to have a strong association with elevated pulmonary capillary wedge pressures both in patients with HFrEF and HFpEF (15,16). In HFrEF, PALS has been correlated with highest burden of symptoms and reduction of functional capacity (14). Also, it has been found to be of particular utility for the prognostic assessment over LV parameters: Carluccio et the overall prediction of HF hospitalization and all-cause death (area under curve, AUC 0.75, 0.70 and 0.68 respectively, p<0.01) (17).…”

Section: Heart Failurementioning

confidence: 99%

Left atrial strain in cardiovascular diseases : An overview of clinical applications

Pastore¹,

Mandoli²,

Santoro³

et al. 2021

Cardiologia Hungarica

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“…Normally, atrial function can be summarized as follows: reservoir, conduit, and contractile [ 22 , 23 , 24 , 25 , 26 ]. The reservoir function affects the other two by creating a passive gradient between chambers and enhancing atrial contraction through stretching fibers (Frank–Starling law).…”

Section: Pathophysiologymentioning

confidence: 99%

Mid-Diastolic Events (L Events): A Critical Review

Virgilio

Monitillo

Santoro

et al. 2021

JCM

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Mid-diastolic events (L events) include three phenomena appreciable on echocardiography occurring during diastasis: mid-diastolic transmitral flow velocity (L wave), mid-diastolic mitral valve motion (L motion), and mid-diastolic mitral annular velocity (L’ wave). L wave is a known marker of advanced diastolic dysfunction in different pathological clinical settings such as left ventricle and atrial remodeling, overloaded states, and cardiomyopathies. Patients with L events have poor outcomes with a higher risk of developing heart failure symptoms and arrhythmic complications, including sudden cardiac death. The exact mechanism underlying the genesis of mid-diastolic events is not fully understood, just as the significance of these events in healthy young people or their presence at the tricuspid valve level. We also report an explicative case of a patient with L events studied using speckle tracking imaging of the left atrium and ventricle at the same reference heartbeat supporting the hypothesis of a post-early diastolic relaxation or a “two-step” ventricular relaxation for L wave genesis. Our paper seeks to extend knowledge about the pathophysiological mechanisms on mid-diastolic events and summarizes the current knowledge.

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The analysis of left atrial function predicts the severity of functional impairment in chronic heart failure: The FLASH multicenter study

Cited by 30 publications

References 25 publications

Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

Left atrial strain in cardiovascular diseases : An overview of clinical applications

Mid-Diastolic Events (L Events): A Critical Review

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