The analysis of animal faeces as a tool to monitor antibiotic usage

Berendsen, B.J.A.; Wegh, Robin S.; Memelink, Joost; Zuidema, T.; Stolker, Linda

doi:10.1016/j.talanta.2014.09.022

Cited by 157 publications

(149 citation statements)

References 36 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…As in humans, when animals consume antibiotics as much as 30 to 90% is released into the manure and urine (Sarmah et al, 2006; Berendsen et al, 2015). Animal excreta has been shown to contaminate the environment with antibiotic resistant bacteria and antibiotics (Udikovic-Kolic et al, 2014; Wichmann et al, 2014).…”

Section: Drivers Of Resistance: Antibioticsmentioning

confidence: 99%

“…This phenomenon was recently demonstrated in a survey of feces from 20 commercial swine and 20 cattle farms in The Netherlands. The study reported antibiotics in 55% of the swine feces from 80% of the swine farms and 75% of the calf feces from 95% of the cattle farms (Berendsen et al, 2015). Among the antibiotics recovered, oxytetracycline, doxycycline, and sulfadiazine were the most frequent, followed by tetracycline, flumequine, lincomycin, and tylosin.…”

Section: Drivers Of Resistance: Antibioticsmentioning

confidence: 99%

See 1 more Smart Citation

Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators

et al. 2016

View full text Add to dashboard Cite

The environment is increasingly being recognized for the role it might play in the global spread of clinically relevant antibiotic resistance. Environmental regulators monitor and control many of the pathways responsible for the release of resistance-driving chemicals into the environment (e.g., antimicrobials, metals, and biocides). Hence, environmental regulators should be contributing significantly to the development of global and national antimicrobial resistance (AMR) action plans. It is argued that the lack of environment-facing mitigation actions included in existing AMR action plans is likely a function of our poor fundamental understanding of many of the key issues. Here, we aim to present the problem with AMR in the environment through the lens of an environmental regulator, using the Environment Agency (England’s regulator) as an example from which parallels can be drawn globally. The issues that are pertinent to environmental regulators are drawn out to answer: What are the drivers and pathways of AMR? How do these relate to the normal work, powers and duties of environmental regulators? What are the knowledge gaps that hinder the delivery of environmental protection from AMR? We offer several thought experiments for how different mitigation strategies might proceed. We conclude that: (1) AMR Action Plans do not tackle all the potentially relevant pathways and drivers of AMR in the environment; and (2) AMR Action Plans are deficient partly because the science to inform policy is lacking and this needs to be addressed.

show abstract

Section: Drivers Of Resistance: Antibioticsmentioning

confidence: 99%

Section: Drivers Of Resistance: Antibioticsmentioning

confidence: 99%

Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Reports on fluoroquinolone concentrations in manure are relatively scarce, however, Zhao et al (2010) showed that also this type of antibiotic animal treatment may lead to high residue concentrations in manure; residue concentrations up to 45 mg kg-1 ciprofloxacin, 1420 mg kg-1 enrofloxacin, 99 mg kg-1 fleroxacin and 225 mg kg-1 norfloxacin were observed. Data for macrolide antibiotics mainly concern tylosin, with maximum concentrations of 8.1 mg kg-1 (Dolliver, 2008) and 7 mg kg-1 (Berendsen, 2015). The latter author also found tilmicosin, tiamulin and lincomycin in their study, levels for these residues were in the µg kg-1 area.…”

Section: Antibiotic Resistance In Food Of Animal Originmentioning

confidence: 78%

“…The latter author also found tilmicosin, tiamulin and lincomycin in their study, levels for these residues were in the µg kg-1 area. Penicillins show poor stability in manure (Berendsen, 2015), possibly due to the presence of ESBL-producing bacteria, explaining the absence of surveillance results for this antibiotic group. For aminoglycosides data on the occurrence in manure are lacking, but this might also be attributable to the fact that this residue group is difficult to include in routine LC/MS methods for antibiotic analysis.…”

Section: Antibiotic Resistance In Food Of Animal Originmentioning

confidence: 99%

“…Very little information on their environmental occurrence is available. Despite their extensive use in livestock farming, no aminoglycosides were found in a broad study on the analysis of animal faeces (Berendsen, 2015). The lack of data prevents any conclusions on the role of aminoglycosides in the environment with respect to antimicrobial resistance.…”

Section: Aminoglycosidesmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotic residues and resistance in the environment

Pikkemaat

Yassin

Fels‐Klerx

et al. 2016

View full text Add to dashboard Cite

Analysis of flumequine enantiomers in rat plasma by UFLC‐ESI‐MS/MS

Wang

Jin

et al. 2016

Chirality

View full text Add to dashboard Cite

In this study the analysis and confirmation of flumequine enantiomers in rat plasma by ultra-fast liquid chromatography coupled with electron spray ionization mass spectrometry (using propranolol as an internal standard [IS]) was developed and validated. Plasma samples were prepared by liquid-liquid extraction using methyl tert-butyl ether as the extraction solvent. Direct resolution of the R- and S-isomers was performed on a CHIRALCEL OJ-RH column (4.6 × 150 mm, 5 μm) using acetonitrile / 0.1% formic acid / 1 mM ammonium acetate as the mobile phase. Detection was operated by electron spray ionization in the selected ion monitoring and positive ion mode. The target ions at m/z 262.1 and m/z 260.1 were selected for the quantification of the enantiomers and IS, respectively. The linear range was 0.5-500 ng/mL. The precisions (coefficient of variation, CV%) and recoveries were 1.43-8.68 and 94.24-106.76%, respectively. The lowest quantitation limit for both enantiomers is 0.5 ng/mL, which is sensitive enough to be applied to sample analysis in other related studies.

show abstract

The analysis of animal faeces as a tool to monitor antibiotic usage

Cited by 157 publications

References 36 publications

Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators

Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators

Antibiotic residues and resistance in the environment

Analysis of flumequine enantiomers in rat plasma by UFLC‐ESI‐MS/MS

Contact Info

Product

Resources

About