The Analysis Between Functional Human Telomerase Reverse Transcriptase MNS16A Polymorphisms and the Risk of Developing Non-Small Cell Lung Cancer in the Taiwanese Population

Chang, Chih Cheng; Yu, Ming Chih; Bai, Kuan Jen; Chang, Jer‐Hwa; Lee, Chun Nee; Fang, Chia Lang; Liu, H. Eugene

doi:10.1016/j.jecm.2011.10.012

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…MNS16A, a functional minisatellite of TERT, discovered in 2003 by Wang et al (16), has been investigated in several malignancies such as lung (16,(21)(22)(23), breast (24), brain (25)(26)(27) and colorectal cancer (17) so far. This study is the first investigating genetic associations of MNS16A concerning PC.…”

Section: Discussionmentioning

confidence: 99%

MNS16A tandem repeat minisatellite of human telomerase gene and prostate cancer susceptibility

et al. 2013

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Telomere dysfunction is an early event in the development of prostate cancer and telomerase (TERT) activity is detectable in the majority of prostate cancers. Genetic variation in TERT and its regulatory elements may influence prostate carcinogenesis. MNS16A, a functional polymorphic tandem repeat minisatellite of TERT, has been studied in several malignancies. We determined MNS16A genotypes in an Austrian case-control study for the first time in the context of prostate cancer, comprising 1165 prostate cancer cases and 674 benign prostate hyperplasia controls with PCR. In addition to the five reported variable number of tandem repeats (VNTRs), we identified VNTR-212, a rare variant, for the first time in a European population. Multiple logistic regression analysis revealed no differences in genotype distribution between cases and controls. However, in stratified analysis, MNS16A VNTR-274 (OR = 0.25, 95% CI = 0.06-0.79, P = 0.016) and genotype 274/302 (OR = 0.13, 95% CI = 0.01-0.58, P = 0.005) were associated with a significantly decreased risk of prostate cancer in the age group >70 years. Our finding of a MNS16A genotype conferring a protective effect against prostate cancer in older men suggests a potential role of this polymorphism in prostate cancer susceptibility but demands to be validated in further studies.

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Section: Discussionmentioning

confidence: 99%

MNS16A tandem repeat minisatellite of human telomerase gene and prostate cancer susceptibility

et al. 2013

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“…The two most common alleles are the VNTR-302 and VNTR-243, followed by rare VNTR-333 and VNTR-272. Recently, two very rare alleles, namely VNTR-364 and VNTR-213, were found in just one subject from Austria (Hofer et al, 2011) and one subject from Taiwan (Chang et al, 2011), respectively. Promoter activity was demonstrated to depend on the number of tandem repeats implicating functionality of MNS16A genotype (Wang et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy

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Lucarini

Carpi

et al. 2013

Experimental Gerontology

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“…After comprehensive searching of 71 articles, we identified 10 relevant publications including 6101 cases and 10521 controls from 13 studies to assess the association between MNS16A and cancer risk (Figure 1): 2 studies focused on glioblastoma [15], [16], 2 studies focused on glioma [15], [16], 3 studies focused on non-small cell lung cancer [14], [17], [18], 2 studies focused on breast cancer[19], [20] and each was one for meningioma [15], colorectal carcinoma [21], nasopharyngeal carcinoma [22] and prostate cancer [23] (Table 1). All studies were case-control studies, of which the most frequently investigated was brain cancer (6451 subjects; 38.81%).…”

Section: Resultsmentioning

confidence: 99%

“…The variants containing short tandem repeats (S allele) have stronger promoter activity than long repeats (L allele), indicating number of tandem repeats associated with lung cancer risk. Subsequently, several malignancies such as cerebral [15], [16], lung [17], [18], breast [19], [20], colorectal [21], nasopharyngeal [22], prostate cancer [23] and one meta-analysis [24] had investigated MNS16A in the etiology of cancer but with inconsistent results. Considering the important role of MNS16A in promoter activity of hTERT gene, we therefore conduct a meta-analysis on eligible articles to estimate association of MNS16A with cancer risk.…”

Section: Introductionmentioning

confidence: 99%

MNS16A Tandem Repeats Minisatellite of Human Telomerase Gene and Cancer Risk: A Meta-Analysis

et al. 2013

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BackgroundResearchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.MethodsA systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.Results10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.ConclusionsThe results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.

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The Analysis Between Functional Human Telomerase Reverse Transcriptase MNS16A Polymorphisms and the Risk of Developing Non-Small Cell Lung Cancer in the Taiwanese Population

Cited by 5 publications

References 12 publications

MNS16A tandem repeat minisatellite of human telomerase gene and prostate cancer susceptibility

MNS16A tandem repeat minisatellite of human telomerase gene and prostate cancer susceptibility

The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy

MNS16A Tandem Repeats Minisatellite of Human Telomerase Gene and Cancer Risk: A Meta-Analysis

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