The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo

Kang, Moonkyu; Jung, In‐Ho; Hur, Jong-Hyun; Kim, Soon Han; Lee, Jeong Hun; Kang, Ji-Yun; Jung, Kyoung Chul; Kim, Kyoung Soo; Yoo, Myung Chul; Park, Dong-Suk; Lee, Jae-Dong; Cho, Yong-Baik

doi:10.1016/j.jep.2010.07.025

Cited by 60 publications

(52 citation statements)

References 46 publications

(41 reference statements)

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“…Similar effects have been reported in several animal models (Kang et al, 2010), as has in vitro evidence of cartilage protection and anti-inflammatory properties suggested by our preliminary data. Both Lonicera japonica Thunb.…”

Section: Introductionsupporting

confidence: 91%

Gastroprotective and safety effects of WIN-34B, a novel treatment for osteoarthritis, compared to NSAIDs

Huh

Lee

Seo

et al. 2011

Journal of Ethnopharmacology

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Section: Introductionsupporting

confidence: 91%

Gastroprotective and safety effects of WIN-34B, a novel treatment for osteoarthritis, compared to NSAIDs

Huh

Lee

Seo

et al. 2011

Journal of Ethnopharmacology

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“…20,21 Recently, it was reported that LJ has anti-inflammatory properties in animal models of osteoarthritis and excision wounding. 22,23 For example, in these animal models, LJ was found to suppress a number of inflammation-related phenomena and the amount of cytokines produced, including TNF-a and IL-6. Moreover, LJ was shown to have anti-inflammatory effects in a carrageenaninduced paw edema inflammation model.…”

Section: Introduction Mmentioning

confidence: 99%

Lonicera japonicaTHUNB. Extract Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses by Suppressing NF-κB Signaling in BV-2 Microglial Cells

Kwon

Hong

et al. 2015

Journal of Medicinal Food

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In the current study, we evaluated the anti-inflammatory effects of Lonicera japonica THUNB. (LJ) and its underlying molecular mechanism in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Our results indicated that LJ significantly inhibits LPS-stimulated production of nitric oxide (NO) and prostaglandin E2 (PGE2). In addition, LJ inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at both the protein and mRNA levels. In LPSstimulated BV-2 microglial cells, LJ inhibited proinflammatory cytokines and chemokines, tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9) enzymatic activities, and/or mRNA expression, as well as reactive oxygen species (ROS) production. LJ significantly suppressed activation of nuclear factor-jB (NF-jB) and its translocation from the cytosol to the nucleus and suppressed the DNA-binding activity of NF-jB. Furthermore, LJ significantly inhibited phosphorylation of c-Jun N-terminal kinase ( JNK), extracellular signalregulated kinase 1/2 (ERK 1/2), p38 mitogen-activated protein kinases (MAPKs), phosphatidylinositol 3-kinases (PI3K)/Akt, and Janus kinase 1 ( JAK1)/signal transducer and activator of transcription (STAT)1/3. Collectively, our findings indicated that the antineuroinflammatory properties of LJ in LPS-induced BV-2 microglial cells is due to downregulation of proinflammatory cytokines and chemokines downstream of inhibition of NF-jB activation.

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“…The carrageen-induced paw edema is acute, well researched and highly reproducible model, and has been commonly employed to assess the anti-edematous effect of natural products (Kang et al, 2010). To estimate the effect of TFA on acute inflammation, we also used carrageenan-induced rat paw edema as an assay to reflect edema that occurs during the early stages of acute inflammation (Matsuda and Tanihata, 1992).…”

Section: Effect Of Tfa On Carrageenan-induced Paw Edema In Ratsmentioning

confidence: 99%

In Vivo and in Vitro Immunomodulatory and Anti-Inflammatory Effects of Total Flavonoids of Astragalus

Guo¹,

Xu²,

Xu³

et al. 2016

Afr J Tradit Complement Altern Med

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The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo

Cited by 60 publications

References 46 publications

Gastroprotective and safety effects of WIN-34B, a novel treatment for osteoarthritis, compared to NSAIDs

Gastroprotective and safety effects of WIN-34B, a novel treatment for osteoarthritis, compared to NSAIDs

Lonicera japonicaTHUNB. Extract Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses by Suppressing NF-κB Signaling in BV-2 Microglial Cells

In Vivo and in Vitro Immunomodulatory and Anti-Inflammatory Effects of Total Flavonoids of Astragalus

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