The amphoteric effect on friction between the bovine cartilage/cartilage surfaces under slightly sheared hydration lubrication mode

Pawlak, Zenon; Gadomski, Adam; Sójka, Michał; Urbaniak, Wiesław; Besdowski, Piotr

doi:10.1016/j.colsurfb.2016.06.027

Cited by 19 publications

(23 citation statements)

References 22 publications

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“…The negatively charged surface of the cartilage with synovial fluid that has a pH of 7.4 is supported by lamellar slippage of bilayers when it is under a load. The measurements of the friction coefficient with liposomes, lamellar phases, and phospholipid bilayers [2] confirmed our hypothesis of low friction in the lamellar-repulsive mechanism [32].…”

Section: The Amphoteric Character Of the Phospholipid Bilayer Surfacesupporting

confidence: 77%

“…This extremely low friction assigned to a low intermediate layer (contact angle ~ 0°), lamellar slippage of bilayers, and a short-range repulsion between the negatively charged (-PO4 − ) cartilage surfaces from the contribution of the hyaluronan and proteoglycans (PGs), which is a glycoprotein, are termed the lubricin and lamellar phospholipid phases [32]. The changes in the articular cartilage charge density were caused by a variation in the pH of the electrolyte solution, which produced different charge densities of the articular cartilage.…”

Section: The Amphoteric Character Of the Phospholipid Bilayer Surfacementioning

confidence: 99%

“…This extremely low friction assigned to a low intermediate layer (contact angle~0 • ), lamellar slippage of bilayers and a short-range repulsion between the negatively charged interfaces (-PO 4 − ) cartilage surfaces from the contribution of the hyaluronan and proteoglycans (PGs), which is a glycoprotein, are termed the lubricin and lamellar phospholipid phases [32].…”

Section: The Amphoteric Character Of the Phospholipid Bilayer Surfacementioning

confidence: 99%

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Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

et al. 2019

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Some solid lubricants are characterized by a layered structure with weak (van der Waals) inter-interlayer forces which allow for easy, low-strength shearing. Solid lubricants in natural lubrication are characterized by phospholipid bilayers in the articular joints and phospholipid lamellar phases in synovial fluid. The influence of the acid–base properties of the phospholipid bilayer on the wettability and properties of the surface have been explained by studying the interfacial tension of spherical lipid bilayers based on a model membrane. In this paper, we show that the phospholipid multi-bilayer can act as an effective solid lubricant in every aspect, ranging from a ‘corrosion inhibitor’ in the stomach to a load-bearing lubricant in bovine joints. We present evidence of the outstanding performance of phospholipids and argue that this is due to their chemical inertness and hydrophilic–hydrophobic structure, which makes them amphoteric and provides them with the ability to form lamellar structures that can facilitate functional sliding. Moreover, the friction coefficient can significantly change for a given phospholipid bilayer so it leads to a lamellar-repulsive mechanism under highly charged conditions. After this, it is quickly transformed to result in stable low-friction conditions.

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Section: The Amphoteric Character Of the Phospholipid Bilayer Surfacesupporting

confidence: 77%

Section: The Amphoteric Character Of the Phospholipid Bilayer Surfacementioning

confidence: 99%

Section: The Amphoteric Character Of the Phospholipid Bilayer Surfacementioning

confidence: 99%

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Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

et al. 2019

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“…Accordingly, reverse micelles can lower the friction coefficient by changing the friction mode in which a quasi-static friction effect can be replaced by its roll-over counterpart [ 30 ]. The latter mechanism occurs at boundary lubrication sites as a result of lubricin, O-linked glycoprotein, and inter-chain interactions between HA and phospholipids [ 34 ]. HA is a key synovial fluid component that provides full viscoelastic properties to the system.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronic acid and phospholipid interactions useful for repaired articular cartilage surfaces—a mini review toward tribological surgical adjuvants

et al. 2017

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This mini review is focused on the emerging nexus between the medical device and pharmaceutical industries toward the treatment of damaged articular cartilage. The physical rationale of hyaluronic acid and phospholipid preparations as tribological surgical adjuvants for repaired articular cartilage surfaces is explored, with directions for possible new research which have arisen due to the therapeutic advance of the physiochemical scalpel. Because synovial joint lubrication regimes become dysfunctional at articular cartilage lesion sites as a result of the regional absence of the surface active phospholipid layer and its inability to reform without surgical repair, hyaluronic acid and phospholipid intra-articular injections have yielded inconsistent efficacy outcomes and only short-term therapeutic benefits mostly due to non-tribological effects. Parameters for hydrophobic-polar type interactions as applied to the lubricating properties of normal and osteoarthritic synovial fluid useful for repaired articular cartilage surfaces are discussed.

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“…Author [1] Cartilage's extremely low friction is significantly dependent on the electrostatic interaction between two cartilage surfaces [6,7]. In an animal's body, where the tissues slide over each other, the lubrication mechanism has been referred to as a "lamellar-repulsive", because the surfaces coated with PL bilayers and lamellar phases negatively charged on articular surface with synovial fluid support this mechanism [8].…”

Section: Introductionmentioning

confidence: 99%

Articular cartilage: Chemical, Physical, and Tribological Properties

Mreła

Pawlak²

2018

JNDC

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The cartilage surface was characterized using wettability test fresh and depleted AC samples. In this work, we demonstrated experimentally that the cartilage smart biomaterial at varies pH is sensitive to friction and introduces a novel concept in joint lubrication on charged surfaces.The surface charge density of the articular cartilage surface is related to the amphoteric character of phospholipids, PLs functional groups (-NH3+) and (-PO4-). The maximum surface energy of AC was found to occur at pH for isoelectric point ~4.5 (H3N+(CH2)n PO4- -R1R2) and with a wide range minimum of pH 6.5 to 9.5 of the phospholipidic membrane covering biological pH ~7.4 lubrication condition. The hydrophilic and hydrophobic character of cartilage was determined.

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The amphoteric effect on friction between the bovine cartilage/cartilage surfaces under slightly sheared hydration lubrication mode

Cited by 19 publications

References 22 publications

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

Hyaluronic acid and phospholipid interactions useful for repaired articular cartilage surfaces—a mini review toward tribological surgical adjuvants

Articular cartilage: Chemical, Physical, and Tribological Properties

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