Hyaluronic acid and phospholipid interactions useful for repaired articular cartilage surfaces—a mini review toward tribological surgical adjuvants

Jung, Stanisław; Petelska, Aneta D.; Bełdowski, Piotr; Augé, Wayne K.; Casey, Tahlia; Walczak, Dominik; Lemke, Krzysztof; Gadomski, Adam

doi:10.1007/s00396-017-4014-z

Cited by 28 publications

(39 citation statements)

References 31 publications

(46 reference statements)

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“…Hyaluronic acid and phosphatidylcholine are important components of the lubricating molecular layer in joint synovial systems. Furthermore, due to their extensive profiles of biocompatibility and their recognized therapeutic applications, these molecules have been recognized as essential candidates for tribological surgical adjuvant design [33].…”

Section: Hyaluronic Acid/phosphatidylcholine Bilayer Interactionsmentioning

confidence: 99%

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

et al. 2019

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Some solid lubricants are characterized by a layered structure with weak (van der Waals) inter-interlayer forces which allow for easy, low-strength shearing. Solid lubricants in natural lubrication are characterized by phospholipid bilayers in the articular joints and phospholipid lamellar phases in synovial fluid. The influence of the acid–base properties of the phospholipid bilayer on the wettability and properties of the surface have been explained by studying the interfacial tension of spherical lipid bilayers based on a model membrane. In this paper, we show that the phospholipid multi-bilayer can act as an effective solid lubricant in every aspect, ranging from a ‘corrosion inhibitor’ in the stomach to a load-bearing lubricant in bovine joints. We present evidence of the outstanding performance of phospholipids and argue that this is due to their chemical inertness and hydrophilic–hydrophobic structure, which makes them amphoteric and provides them with the ability to form lamellar structures that can facilitate functional sliding. Moreover, the friction coefficient can significantly change for a given phospholipid bilayer so it leads to a lamellar-repulsive mechanism under highly charged conditions. After this, it is quickly transformed to result in stable low-friction conditions.

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Section: Hyaluronic Acid/phosphatidylcholine Bilayer Interactionsmentioning

confidence: 99%

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

et al. 2019

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“…For instance, it has been reported that addition of hyaluronan and phospholipids together is more effective in alleviating joint disease symptoms than any of these two components alone. 9 In model experiments hyaluronan-phospholipid mixtures have also shown synergies, 10,11 and the importance of hyaluronan-phospholipid association structures for repaired articular cartilage surfaces 12 and for lubrication of hip implants 13 has been stressed. Different aspects of biolubrication and biomimetic lubrication have been the topic of several valuable reviews that we recommend to the interested reader.…”

Section: Introductionmentioning

confidence: 99%

Synergies in lubrication

Dédinaité

Claesson

2017

Phys. Chem. Chem. Phys.

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To slide surfaces against each other with application of a minimum force and minimum wear has been important since ancient times, and it remains equally important today. The use of oil-soluble lubricants is widely spread in technology, whereas living organisms have developed water-soluble lubricants to facilitate sliding motions. In this perspective article we focus on water-based lubrication in the boundary lubrication regime, and particularly lubrication synergies. This focus has, of course, found inspiration from the outstanding lubrication properties of synovial joints. It has ignited significant amount of research, mostly aimed at answering the question: Which molecule is the magic biolubricant? Different research groups have advocated different answers, and the debate has been intensive. In this article we argue that the question in itself is inappropriate. The relevant question is rather the following: How do molecules work in synergy to provide superior lubrication?

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“…One possible explanation for the lipid peak weakening is that the damage treatments may have exposed the lipids embedded within the articular surface and allowed them to dissolve in the PBS solution. The lack of surface-active lipid bilayer is seen on damaged AC surface , Jung et al 2017. Furthermore, the EDTA present within PBS solution during storage could have caused the lipids to dissolve.…”

Section: Discussionmentioning

confidence: 99%

Infrared fiber optic spectroscopy detects bovine articular cartilage degeneration

Virtanen

Nippolainen

Shaikh

et al. 2020

Preprint

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Articular cartilage (AC) is a soft connective tissue that covers the ends of articulating bones. Joint injuries may lead to degeneration of cartilage tissue and initiate development of post-traumatic osteoarthritis (OA). Arthroscopic surgeries can be used to treat joint injuries, but arthroscopic evaluation of cartilage quality is subjective. Therefore, new methods are needed for objective assessment of cartilage degeneration. Fourier transform infrared (FTIR) spectroscopy can be used to assess tissue composition based on the fundamental molecular vibrations. When combined with fiber optics and attenuated total reflectance (ATR) crystal, the measurements can be done flexibly without any sample processing. We hypothesize that Fourier transform infrared attenuated total reflection (FTIR-ATR) spectroscopy can detect enzymatically and mechanically induced changes similar to changes occurring during progression of OA. Fresh bovine patellar cartilage plugs (n = 60) were extracted and degraded enzymatically and mechanically. Adjacent untreated control samples (n = 60) were utilized as controls. Enzymatic degradation was implemented by 90-min and 24-hour collagenase as well as 30-min trypsin treatments. Mechanical damage was induced by: 1) dropping a weight impactor on the cartilage plugs, and 2) abrading the cartilage surface with a rotating sandpaper. Fiber optic FTIR-ATR spectroscopic measurements were conducted for control and degraded samples, and spectral changes were assessed with random forest (RF), partial least squares discriminant analysis (PLS-DA), and support vector machine (SVM) classifiers. RF (accuracy 93.1 % to 79.2 %), PLS-DA (accuracy 95.8% to 81.9%), and SVM (accuracy 91.7% to 80.6%) all had excellent classification performance for detecting the different enzymatic and mechanical damage on cartilage matrix. The results suggest that fiber optic FTIR-ATR spectroscopy is a viable way to detect minor degeneration of AC.

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Hyaluronic acid and phospholipid interactions useful for repaired articular cartilage surfaces—a mini review toward tribological surgical adjuvants

Cited by 28 publications

References 31 publications

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

Synergies in lubrication

Infrared fiber optic spectroscopy detects bovine articular cartilage degeneration

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