The ameliorative effect of propolis against methoxychlor induced ovarian toxicity in rat

Elsharkawy, Eman E.; Kames, Amany O.G.; Sayed, Samia M.; Nisr, Neveen A. E.L.; Wahba, Nahed M.; Elsherif, Walaa M.; Nafady, Asmaa; Abdel-Hafeez, M. M.; Aamer, A. A.

doi:10.1016/j.etp.2014.06.003

Cited by 23 publications

(17 citation statements)

References 46 publications

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“…1). This has been shown for numerous substances: BPA [47], phthalates (DEHP [39, 41], DBP [38]), PAH [41, 96], cigarette smoke [65, 76, 77, 79, 82], pesticides [51–54], dioxins [100], genistein [91], PCB [104]. Secondly, a decreased pool of primordial follicles (situation 5 in Fig.…”

Section: Discussionmentioning

confidence: 92%

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Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data

et al. 2017

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Background: Because only 25% of cases of premature ovarian insufficiency (POI) have a known etiology, the aim of this review was to summarize the associations and mechanisms of the impact of the environment on this pathology. Main body of the abstract: Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included ovary, follicle, oocyte, endocrine disruptor, environmental exposure, occupational exposure, environmental contaminant, pesticide, polyaromatic hydrocarbon, polychlorinated biphenyl PCB, phenol, bisphenol, flame retardant, phthalate, dioxin, phytoestrogen, tobacco, smoke, cigarette, cosmetic, xenobiotic. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the terms and published in English. We have excluded articles that included results that did not concern ovarian pathology and those focused on ovarian cancer, polycystic ovary syndrome, endometriosis or precocious puberty. We have also excluded genetic, auto-immune or iatrogenic causes from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on follicular development and follicular atresia and the molecular pathways involved. Ninety-seven studies appeared to be eligible and were included in the present study, even though few directly address POI. Phthalates, bisphenol A, pesticides and tobacco were the most reported substances having a negative impact on ovarian function with an increased follicular depletion leading to an earlier age of menopause onset. These effects were found when exposure occured at different times throughout the lifetime from the prenatal to the adult period, possibly due to different mechanisms. The main mechanism seemed to be an increase in atresia of pre-antral follicles. Conclusion: Environmental pollutants are probably a cause of POI. Health officials and the general public must be aware of this environmental effect in order to implement individual and global preventive actions.

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Section: Discussionmentioning

confidence: 92%

“…Exposure to Simazine [53], a herbicide from the triazine family, or to Methoxychlor (MXC) [54] an organophosphate pesticide, led to a decrease in total ovary weight, which is a sign of follicular atresia [55, 56]. Prenatal exposure to MXC in rats showed modifications to DNA methylation, which suggests epigenetic mechanisms [57].…”

Section: Resultsmentioning

confidence: 99%

Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data

et al. 2017

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“…MXC exposure was reported to specifically target ovarian antral follicles, leading to persistent vaginal estrus, decreased ovarian weight and ovulation, and increased atresia of the large follicles (Martinez and Swartz, 1991;Borgeest et al, 2002). One proposed mechanism of action for MXC is the induction of granulosa cell apoptosis and aberrant cumulus expansion through its estrogen effects (El-Sharkawy et al, 2014;Bhardwaj and Saraf, 2015), although reports also indicate that MXC can induced oxidative stress in the ovary, resulting in impaired mitochondrial respiration, increased production of hydrogen peroxide, and DNA damage (Gupta et al, 2006b).…”

Section: Introductionmentioning

confidence: 99%

Methoxychlor exposure induces oxidative stress and affects mouse oocyte meiotic maturation

et al. 2016

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Methoxychlor (MXC) is used worldwide against insects and other pests. This organochlorine pesticide acts as a xenoestrogen, promotes oxidative stress, and is considered cytotoxic and genotoxic, causing abortions and stillbirths in females. Mechanistically related estrogens and oxidants affect oocyte meiosis, so we investigated the effects of MXC on mouse oocyte meiotic maturation. Our results showed that maturation rates of MXC-treated oocytes were lower than those of controls, which was due to abnormal spindle morphologies and DNA double-strand breaks, as confirmed by increased γ-H2AX foci. Our findings also suggest that MXC may affect oocyte quality by causing the accumulation of superoxide radicals and other reactive oxygen species, aberrant mitochondrial distribution, decreased mitochondrial membrane potential, and increased lipid peroxidation. Thus, exposure to MXC negatively affects oocyte meiotic maturation, primarily through impairments in cellular ROS metabolism. Mol. Reprod. Dev. 83: 768-779, 2016 © 2016 Wiley Periodicals, Inc.

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“…Propolis appears effective in decreasing the MXC‐induced ovarian toxicity in rats (El‐Sharkawy et al ). Propolis neutralizes the reduced body and ovarian weight, and declines the level of serum estradiol and progesterone due to MXC exposure.…”

Section: Strategies Used To Reduce Insecticides‐induced Toxicitymentioning

confidence: 99%

Insecticides and ovarian functions

Sharma

Singh

Setia

et al. 2020

Environ and Mol Mutagen

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Insecticides, a heterogeneous group of chemicals, are widely used in agriculture and household practices to avoid insect‐inflicted damage. Extensive use of insecticides has contributed substantially to agricultural production and the prevention of deadly diseases by destroying their vectors. On the contrary, many of the insecticides are associated with several adverse health effects like neurological and psychological diseases, metabolic disorders, hormonal imbalance, and even cancer in non‐target species, including humans. Reproduction, a very selective process that ensures the continuity of species, is affected to a greater extent by the rampant use of insecticides. In females, exposure to insecticides leads to reproductive incapacitation primarily through disturbances in ovarian physiology. Disturbed ovarian activities encompass the alterations in hormone synthesis, follicular maturation, ovulation process, and ovarian cycle, which eventually lead to decline in fertility, prolonged time‐to‐conceive, spontaneous abortion, stillbirths, and developmental defects. Insecticide‐induced ovarian toxicity is effectuated by endocrine disruption and oxidative stress. Oxidative stress, which occurs due to suppression of antioxidant defense system, and upsurge of reactive oxygen and nitrogen species, potentiates DNA damage and expression of apoptotic and inflammatory markers. Insecticide exposure, in part, is responsible for ovarian malfunctioning through disruption of hypothalamic–pituitary–gonadal axis. The current article is focused on the adverse effects of insecticides on ovarian functioning, and consequently, on the reproductive efficacy of females. The possible strategies to combat insecticide‐induced toxicity are also discussed in the latter part of this review. Environ. Mol. Mutagen. 61:369–392, 2020. © 2020 Wiley Periodicals, Inc.

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The ameliorative effect of propolis against methoxychlor induced ovarian toxicity in rat

Cited by 23 publications

References 46 publications

Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data

Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data

Methoxychlor exposure induces oxidative stress and affects mouse oocyte meiotic maturation

Insecticides and ovarian functions

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