Methoxychlor exposure induces oxidative stress and affects mouse oocyte meiotic maturation

Liu, Yu; Wang, Yalong; Chen, Ming-Huang; Zhang, Zhen; Xu, Bai-Hui; Liu, Rui; Xu, Lin; He, Shuwen; Qi, Zhongquan; Wang, Hailong

doi:10.1002/mrd.22683

Cited by 24 publications

(17 citation statements)

References 54 publications

(58 reference statements)

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“…Exposure to pesticides might cause generalized oxidative stress (49), with the elevated production of free radicals and impacts on superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione transferase. This might explain why oocyte quality is impacted; oocyte dysmorphisms may reflect poor competence for development into a good embryo for implantation.…”

Section: Impact On Oocyte Qualitymentioning

confidence: 99%

“…Many studies have found an association between pesticide concentrations in the follicular fluid on one hand and the number and quality of oocytes collected for IVF ( 47 , 48 ), endometrial thickness, and embryo implantation rates ( 46 ) on the other. Studies of animal models have shown that pesticide exposure is associated with elevated oxidative stress, which may be responsible for the observed alterations ( 49 ).…”

Section: Pesticide Exposure and Female Fertilitymentioning

confidence: 99%

“…Moreover, exposure to deltamethrin (another common insecticide) in a mouse model was linked to cellular oxidative stress and meiotic abnormalities via DNA damage ( 63 ). Liu et al ( 49 ) suggested that MXC exposure induces oxidative stress and affects mouse oocyte meiotic maturation via the accumulation of superoxide radicals and other reactive oxygen species (ROS), aberrant mitochondrial distribution, a low mitochondrial membrane potential, and elevated lipid peroxidation. Thus, exposure to MXC can negatively affect oocyte meiotic maturation – primarily through impairments in cellular metabolism.…”

Section: Pesticide Exposure and Female Fertilitymentioning

confidence: 99%

“…Blastocyst formation and the number of cells per blastocyst declined with the concentration of organochlorines ( 48 ) and atrazine ( 52 ). Furthermore, the association of pesticides like deltamethrin ( 63 ) and MXC ( 49 ) with poor metabolic and genetic status during embryo development might be due to the impairment of various biochemical pathways ( 13 ) and high ROS production. Moreover, high ROS concentrations and generalized oxidative stress are likely to affect the integrity of cellular constituents, such as DNA and proteins ( 68 , 69 , 70 ).…”

Section: Pesticide Exposure and Female Fertilitymentioning

confidence: 99%

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The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

Cabry¹,

Merviel²,

Madkour

et al. 2020

Endocrine Connections

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The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (1) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects and poor IVF outcomes, and (2) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates, and elevated risk of miscarriage associated with exposure to high doses of pesticides.

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Section: Impact On Oocyte Qualitymentioning

confidence: 99%

Section: Pesticide Exposure and Female Fertilitymentioning

confidence: 99%

Section: Pesticide Exposure and Female Fertilitymentioning

confidence: 99%

Section: Pesticide Exposure and Female Fertilitymentioning

confidence: 99%

See 2 more Smart Citations

The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

Cabry¹,

Merviel²,

Madkour

et al. 2020

Endocrine Connections

View full text Add to dashboard Cite

show abstract

“…2006b). Mouse oocytes cultured with methoxychlor showed oxidative stress and impaired spindle formation (Liu et al. 2016).…”

Section: Description Of the Key Characteristics Of Female Reproductivmentioning

confidence: 99%

Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment

Luderer

Eskenazi

Hauser

et al. 2019

Environ Health Perspect

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Background:Identification of female reproductive toxicants is currently based largely on integrated epidemiological and in vivo toxicology data and, to a lesser degree, on mechanistic data. A uniform approach to systematically search, organize, integrate, and evaluate mechanistic evidence of female reproductive toxicity from various data types is lacking.Objective:We sought to apply a key characteristics approach similar to that pioneered for carcinogen hazard identification to female reproductive toxicant hazard identification.Methods:A working group of international experts was convened to discuss mechanisms associated with chemical-induced female reproductive toxicity and identified 10 key characteristics of chemicals that cause female reproductive toxicity: 1) alters hormone receptor signaling; alters reproductive hormone production, secretion, or metabolism; 2) chemical or metabolite is genotoxic; 3) induces epigenetic alterations; 4) causes mitochondrial dysfunction; 5) induces oxidative stress; 6) alters immune function; 7) alters cell signal transduction; 8) alters direct cell–cell interactions; 9) alters survival, proliferation, cell death, or metabolic pathways; and 10) alters microtubules and associated structures. As proof of principle, cyclophosphamide and diethylstilbestrol (DES), for which both human and animal studies have demonstrated female reproductive toxicity, display at least 5 and 3 key characteristics, respectively. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), for which the epidemiological evidence is mixed, exhibits 5 key characteristics.Discussion:Future efforts should focus on evaluating the proposed key characteristics against additional known and suspected female reproductive toxicants. Chemicals that exhibit one or more of the key characteristics could be prioritized for additional evaluation and testing. A key characteristics approach has the potential to integrate with pathway-based toxicity testing to improve prediction of female reproductive toxicity in chemicals and potentially prevent some toxicants from entering common use. https://doi.org/10.1289/EHP4971

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The toxic effects of Fluorene‐9‐bisphenol on porcine oocyte in vitro maturation

Jiao

Ding

Meng

et al. 2019

Environmental Toxicology

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Fluorene‐9‐bisphenol (9,9‐bis(4‐hydroxyphenyl)‐fluorene [BHPF]) is a bisphenol A (BPA) substitute used in the production of “BPA‐free” plastics, now has been identified is harmful to living organisms. Our previous study showed that BHPF impaired mouse denuded oocyte in vitro maturation. However, there is a question that whether BHPF is still able to affect oocyte maturation in the presence of dense cumulus cells. In the present study, we checked the toxic effects of BHPF on porcine oocyte maturation which is derived from COCs in vitro culture. Our results showed that BHPF (50 μM) inhibited the expansion of cumulus cells, led to a significant decrease in polar body extrusion (PBE). Importantly, BHPF resulted in abnormal spindle assembly, ATP level decrease, reactive oxygen species (ROS) accumulation and early apoptosis in porcine oocytes, which are all negative to oocyte maturation. Furthermore, BHPF also declined porcine oocyte quality by disturbing the cortical granules (CGs) distribution. In conclusion, our study showed that BHPF still inhibited oocyte maturation even in the presence of cumulus cells leading to abnormal spindle assembly, ATP decrease, increased ROS level, early apoptosis, and disturbed CGs distribution in porcine oocytes, and also indicates that BHPF has a wide range toxic effects on oocyte in different species.

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Methoxychlor exposure induces oxidative stress and affects mouse oocyte meiotic maturation

Cited by 24 publications

References 54 publications

The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment

The toxic effects of Fluorene‐9‐bisphenol on porcine oocyte in vitro maturation

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