The ameliorative effect of <i>Lactobacillus plantarum</i> Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet

Liu, Yujun; Gao, Yuan; Ma, Fenglian; Mu, Guangqing; Sun, Mengying

doi:10.1039/d0fo00439a

Cited by 56 publications

(44 citation statements)

References 67 publications

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“…Probiotic mixture VSL#3 was found to reduce the levels of TNF-α and concomitantly augment IL-10 in a diabetic mice model fed for 12 weeks [26]. Similar studies have shown the effects of probiotic lactobacilli on inflammatory markers [20,27]. Our findings are consistent with previous reports suggesting the anti-inflammatory potential of Lact.…”

Section: Discussionsupporting

confidence: 91%

Lactobacillus fermentum MCC2759 and MCC2760 Alleviate Inflammation and Intestinal Function in High-Fat Diet-Fed and Streptozotocin-Induced Diabetic Rats

Archer¹,

Peddha

Halami³

2021

Probiotics & Antimicro. Prot.

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The growing incidence of type 2 diabetes and obesity has become a worldwide crisis with increased socio-economic burden. Changes in lifestyle and food habits resulting in dysbiosis of the gut microbiota and low-grade inflammation are linked to the rising incidence. The aim of this study was to investigate the effects of potential probiotic Lactobacillus fermentum MCC2759 and MCC2760 on intestinal markers of inflammation using a high-fat diet (HFD)-fed model and a streptozotocin (STZ)-induced diabetic model. Lact. fermentum administration showed improved oral glucose tolerance compared with the model controls of HFD (AUC 1518) and STZ (628.8). Plasma insulin levels improved in the Lact. fermentum treated groups of HFD + MCC2759 (129 ± 4.24 pmol/L) and HFD + MCC2760 (151.5 ± 9.19 pmol/L) in HFD study, while in STZ diabetic study, the insulin levels were normalized with Lact. fermentum administration, for D + MCC2759 (120.5 ± 7.77) and D + MCC2760 (138 ± 5.65 pmol/L) groups. The results showed reduction in inflammatory tone in liver, muscle, and adipose tissues of rats in both models with stimulation of anti-inflammatory IL-10 by real-time quantitative polymerase chain reaction. Additionally, the potential probiotic cultures also displayed normalization of markers related to intestinal barrier integrity (ZO-1), TLR-4 receptor, and insulin sensitivity (GLUT-4, GLP-1, adiponectin). Thus, the results suggest that Lact. fermentum could act as potential probiotic for lifestyle-related disorders such as obesity, diabetes, and metabolic syndrome as both prophylactic and adjunct therapies.

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Section: Discussionsupporting

confidence: 91%

Lactobacillus fermentum MCC2759 and MCC2760 Alleviate Inflammation and Intestinal Function in High-Fat Diet-Fed and Streptozotocin-Induced Diabetic Rats

Archer¹,

Peddha

Halami³

2021

Probiotics & Antimicro. Prot.

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“…Consumption of oily foods continually produces triglycerides, and adipocytes start to die, thereby activating immune cells, causing inflammatory conditions such as fatty liver disease and inflammatory bowel disease [ 28 , 29 ]. Several studies have reported that consumption of lactobacilli is associated with decreased body fat [ 30 , 31 ]. Lactobacillus gasseri BNR17 (BNR17), isolated from human breast milk, inhibited increases in adipocyte tissue weight in high-sucrose diet-fed Sprague-Dawley rats [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lactobacillus gasseri BNR17 (BNR17), isolated from human breast milk, inhibited increases in adipocyte tissue weight in high-sucrose diet-fed Sprague-Dawley rats [ 30 ]. Oral treatment with L. plantarum Y44 and a high-fat diet decreased the epididymal adipocyte area compared with that of the HFD group [ 31 ]. The present study demonstrated and confirmed that L. plantarum K2 and K6 have anti-obesity effects in rats like other lactobacilli.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation

Park

Kim

et al. 2021

IJMS

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Obesity has become a worldwide health problem, and many significant inflammatory markers have been associated with the risk of side effects of obesity and obesity-related diseases. After a normal diet or high-fat diet with high-fructose water (HFHF) for 8 weeks, male Wistar rats were divided randomly into four experimental groups according to body weight. Next, for 8 weeks, a normal diet, HFHF diet, and HFHF diet with L. plantarum strains ATG-K2 or ATG-K6 were administered orally. Compared to the control group, the HFHF diet group showed significantly increased visceral fat, epididymal fat, and liver weight. The mRNA and protein expression levels of FAS and SREBP-1c were higher in the HFHF diet group than in the HFHF diet with L. plantarum strains ATG-K2 and ATG-K6. The HFHF diet with L. plantarum strain ATG-K2 showed significantly decreased inflammatory cytokine expression in the serum and small intestine compared to the HFHF diet group. Furthermore, histological morphology showed minor cell injury, less severe infiltration, and longer villi height in the small intestine ileum of the HFHF diet with L. plantarum strains groups than in the HFHF diet group. These results suggest that L. plantarum strains K2 and K6 may help reduce intestinal inflammation and could be used as treatment alternatives for intestinal inflammatory reactions and obesity.

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“…P. freudenreichii MJ2 effectively inhibited lipid accumulation and adipocyte differentiation, and the antiobesity effect of P. freudenreichii MJ2 was proven to be superior to that of L. plantarum, which is known as an antiobesity probiotic bacterium. L. plantarum shows improvement effects on lipid metabolism disorder in HFD-fed mice by modulating gut microbiota 28 .…”

Section: Discussionmentioning

confidence: 99%

Antiobesity and antidiabetic effects of the dairy bacterium Propionibacterium freudenreichii MJ2 in high-fat diet-induced obese mice by modulating lipid metabolism

Park

Lim

2021

Sci Rep

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Obesity can cause chronic metabolic disorders such as type 2 diabetes, hyperlipidemia, and nonalcoholic fatty liver diseases. The aim of this study was to investigate the antiobesity and antidiabetic effects of the dairy bacterium P. freudenreichii MJ2 isolated from raw milk using 3T3-L1 cells and high-fat diet (HFD)-induced obese mice. Lipid accumulation and the expression levels of genes related to lipid metabolism, such as preadipocytic gene (Pref-1), adipogenic genes (PPARγ and C/EBPα), and lipogenic genes (FAS, SCD-1, and ACC), significantly decreased in heat-killed P. freudenreichii MJ2 (hkMJ2)-treated adipocytes. Live P. freudenreichii MJ2 (MJ2), hkMJ2, and Lactobacillus plantarum (LP) decreased body weight gain in HFD-induced obese mice compared with the model group. The liver and epididymal white adipose tissue weights in the MJ2-, hkMJ2- and LP-treated groups were significantly lower than those in the model group. The expression levels of genes and proteins related to adipogenesis and lipogenesis significantly decreased and lipolysis (HSL and ATGL) increased in the MJ2-, hkMJ2-, and LP-treated groups. The expression levels of genes related to fatty acid β-oxidation (CPT-1α and ACOX1) increased in the MJ2-, hkMJ2-, and LP-treated groups. In addition, blood glucose and fasting insulin levels in the MJ2- and hkMJ2-treated groups decreased compared with those in the model group. P. freudenreichii MJ2 ameliorate insulin resistance by obesity. In conclusion, both MJ2 and hkMJ2 alleviate obesity and metabolic syndrome.

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The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet

Abstract: In our previous studies, Lactobacillus plantarum Y44 showed antioxidant activity and favorable gastric and intestinal transit tolerance.

Cited by 56 publications

References 67 publications

Lactobacillus fermentum MCC2759 and MCC2760 Alleviate Inflammation and Intestinal Function in High-Fat Diet-Fed and Streptozotocin-Induced Diabetic Rats

Lactobacillus fermentum MCC2759 and MCC2760 Alleviate Inflammation and Intestinal Function in High-Fat Diet-Fed and Streptozotocin-Induced Diabetic Rats

Lactobacillus plantarum ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation

Antiobesity and antidiabetic effects of the dairy bacterium Propionibacterium freudenreichii MJ2 in high-fat diet-induced obese mice by modulating lipid metabolism

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