The Alteration human of gut microbiota and metabolites before and after renal transplantation

Yu, Dong; Niu, Ying; Lian, Zhao; Fa, Ye Qi

doi:10.1016/j.micpath.2021.105191

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…The relevant data support the interconnection between gut microbial profiles and the outcomes in renal transplantation [ 149 ]. Great amounts of research have highlighted that the microflora alteration is induced by the elevated administration of immunosuppressants and antimicrobial-prophylactic drugs to prevent graft failure and infections.…”

Section: Fmt and Kidney Diseasementioning

confidence: 93%

“…Magruder et al demonstrated that dysbiosis could be connected with the occurrence of a urinary tract infection (UTI) in transplanted patients [ 153 ]. As mentioned previously, the evaluation of metabolic profiles has been considered a hallmark of bacterial richness and diversity [ 149 ]. Poesen and colleagues observed that PBUTs derived from kidney-transplanted patients were reduced in patients with CKD [ 117 ].…”

Section: Fmt and Kidney Diseasementioning

confidence: 99%

See 1 more Smart Citation

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Caggiano

Stasi

Franzin

et al. 2023

Toxins

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During the past decades, the gut microbiome emerged as a key player in kidney disease. Dysbiosis-related uremic toxins together with pro-inflammatory mediators are the main factors in a deteriorating kidney function. The toxicity of uremic compounds has been well-documented in a plethora of pathophysiological mechanisms in kidney disease, such as cardiovascular injury (CVI), metabolic dysfunction, and inflammation. Accumulating data on the detrimental effect of uremic solutes in kidney disease supported the development of many strategies to restore eubiosis. Fecal microbiota transplantation (FMT) spread as an encouraging treatment for different dysbiosis-associated disorders. In this scenario, flourishing studies indicate that fecal transplantation could represent a novel treatment to reduce the uremic toxins accumulation. Here, we present the state-of-the-art concerning the application of FMT on kidney disease to restore eubiosis and reverse the retention of uremic toxins.

show abstract

Section: Fmt and Kidney Diseasementioning

confidence: 93%

Section: Fmt and Kidney Diseasementioning

confidence: 99%

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Caggiano

Stasi

Franzin

et al. 2023

Toxins

View full text Add to dashboard Cite

show abstract

Facile preparation of nitrogen/titanium-rich porous organic polymers for specific enrichment of N-glycopeptides and phosphopeptides

Wang,

Zhang,

Yan

et al. 2024

Anal. Methods

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The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?

García-Martínez

Borriello

Capolongo

et al. 2023

Biology

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Kidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy required to preserve graft function is associated with the development of post-transplant complications, including infections, altered immunosuppressive metabolism, gastrointestinal toxicity, and diarrhea. The gut microbiota has emerged as a potential therapeutic target for personalizing immunosuppressive therapy and managing post-transplant complications. This review reports current evidence on gut microbial dysbiosis in kidney transplant recipients, alterations in their gut microbiota associated with kidney transplantation outcomes, and the application of gut microbiota intervention therapies in treating post-transplant complications.

show abstract

The Alteration human of gut microbiota and metabolites before and after renal transplantation

Cited by 4 publications

References 25 publications

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Facile preparation of nitrogen/titanium-rich porous organic polymers for specific enrichment of N-glycopeptides and phosphopeptides

The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?

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