The Alopecia Areata Consensus of Experts (ACE) study part II: Results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata

Meah, Nekma; Wall, Dmitri; York, Katherine; Bhoyrul, Bevin; Bokhari, Laita; Asz-Sigall, Daniel; Bergfeld, Wilma F.; Betz, Regina C.; Blume-Peytavi, Ulrike; Callender, Valerie D.; Chitreddy, Vijaya; Combalía, Andrea; Cotsarelis, George; Craiglow, Brittany G.; Donovan, Jeff; Eisman, Samantha; Farrant, Paul; Green, Jack; Grimalt, Ramón; Harries, Matthew; Hordinsky, Maria; Irvine, Alan D.; Itami, Satoshi; Jolliffe, Victoria; King, Brett; Lee, Won Soo; McMichael, Amy J.; Messenger, A.G.; Mirmirani, Paradi; Olsen, Elise A.; Orlow, Seth J.; Piraccini, Bianca Maria; Rakowska, Adriana; Reygagne, P.; Roberts, Janet L.; Rudnicka, Lidia; Shapiro, Jerry; Sharma, Pooja; Tosti, Antonella; Vogt, Annika; Wade, Martin; Yip, Leona; Zlotogorski, Abraham; Sinclair, Rodney

doi:10.1016/j.jaad.2020.09.028

Cited by 35 publications

(44 citation statements)

References 22 publications

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“…Im Zusammenhang mit einer AA ist eine einzige Biopsie in der Regel ausreichend, um die Diagnose zu stellen. Die Biopsie sollte am Rand des umschriebenen Herdes durchgeführt werden, und eine für androgenetische Alopezie typische Stelle sollte vermieden werden [53]. Die histopathologischen Befunde bei AA hängen von der Aktivität der Krankheit zum Zeitpunkt der Biopsie ab (Abbildung 6).…”

Section: Biopsieunclassified

Alopecia areata – Aktuelles Verständnis und Management

Lintzeri

Constantinou

Hillmann

et al. 2022

J Deutsche Derma Gesell

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Die Alopecia areata (AA) ist eine chronische immunvermittelte Erkrankung, die durch akuten oder chronischen, nicht vernarbenden Haarausfall gekennzeichnet ist. Die klinischen Erscheinungsformen sind sehr unterschiedlich und reichen von kleinen umschriebenen haarlosen Stellen bis hin zum vollständigen Verlust der Kopf-und Körperbehaarung. Diese Übersicht soll aktuelles Wissen zu Pathophysiologie und beteiligten Signalwegen vermitteln sowie diagnostische und therapeutische Empfehlungen geben. Aktuell verfügbare Therapieansätze bei AA, einschließlich topischer, systemischer und injizierbarer Interventionen, zeigen unterschiedlich gutes Ansprechen mit häufigen Rezidiven, was den dringenden Bedarf an effektiven zielgerichteten Therapien widerspiegelt. Neue therapeutische Ansätze und Konzepte, einschließlich Januskinase-Inhibitoren, werden mit großer Spannung erwartet. Diese Übersicht diskutiert traditionelle und neue Therapieansätze für das Management der AA. Diese Erkrankung führt häufig zu einer starken psychosozialen Belastung für die Betroffenen, kann zu Depressionen führen, Angstzustände auslösen und die Lebensqualität beeinträchtigen. Daher sollten psychosoziale Aspekte der Krankheit mit berücksichtigt, beim Patienten angesprochen und die Notwendigkeit einer psychologischen Unterstützung erwogen werden.

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Section: Biopsieunclassified

Alopecia areata – Aktuelles Verständnis und Management

Lintzeri

Constantinou

Hillmann

et al. 2022

J Deutsche Derma Gesell

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“…In clinical practice, routine blood tests and screening for autoimmune diseases are not recommended for all patients at the time of AA diagnosis, but rather, only to those showing related clinical signs or symptoms [53,77]. In pediatric patients though, routine thyroid function screening should be additionally considered in case of medical history of atopy or Down syndrome or a family history of thyroid disease [77].…”

Section: Comorbidities and Associated Autoimmune Diseasesmentioning

confidence: 99%

Alopecia areata – Current understanding and management

Lintzeri

Constantinou

Hillmann

et al. 2022

J Deutsche Derma Gesell

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Alopecia areata (AA) is a chronic, immune-mediated disease characterized by acute or chronic non-scarring hair loss, with a heterogeneity in clinical manifestations ranging from patchy hair loss to complete scalp and body hair loss. An overview of the up-to-date pathophysiology and the underlying signaling pathways involved in AA together with diagnostic and therapeutic recommendations will be provided. Current treatments, including topical, systemic and injectable interventions show varying response and frequent relapses reflecting the unmet clinical need. Thus, the new emerging concepts and therapeutic approaches, including Janus kinase inhibitors are eagerly awaited. Traditional and emerging therapies of AA will be discussed, in order to provide physicians with guidance for AA management. Since the latter is so challenging and often tends to take a chronic course, it can have an enormous psychosocial burden on patients, compromising their quality of life and often causing depression and anxiety. Therefore, the psychosocial aspects of the disease need to be evaluated and addressed, in order to implement appropriate psychological support when needed.

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“…90 However, the Alopecia Areata Consensus of Experts (ACE) group has proposed a consensus on the outcome measures for AA patients, which recommended that measurement of HRQoL is required in clinical trials. 91 If core outcome sets for alopecia have been successfully developed and complied with, the problem might be resolved to some extent. Nevertheless, for clinical trials using split-scalp, intraindividual comparisons, it should be difficult to apply HRQoL measurements because each patient, whose HRQoL is measured once, receives more than one treatment.…”

Section: Some Issues Concerning the Use Of Health-related Quality Of Life Measures In Alopecia Patientsmentioning

confidence: 99%

Measuring Patient Quality of Life Following Treatment for Alopecia

Thadanipon¹,

Suchonwanit²

2021

PPA

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Alopecia is a challenging problem for both physicians and patients in terms of diagnosis and treatment. Alopecia usually has negative effects on patients' emotional and psychological well-being. Several studies have examined the effect of alopecia on patients' health-related quality of life (HRQoL) and have consistently reported poor scores. However, deeper insight into the impact of alopecia on affected individuals and its measurement using HRQoL questionnaires is lacking in the literature. In this article, the methods for measuring the HRQoL of patients with alopecia were comprehensively reviewed. Their applications and limitations were also discussed.

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The Alopecia Areata Consensus of Experts (ACE) study part II: Results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata

Cited by 35 publications

References 22 publications

Alopecia areata – Aktuelles Verständnis und Management

Alopecia areata – Aktuelles Verständnis und Management

Alopecia areata – Current understanding and management

Measuring Patient Quality of Life Following Treatment for Alopecia

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