The Alkaloids of Lindera strychnifolia (SIEB. et ZUCC.) F. VILL. and Lindera umbellata THUNB.

Tomita, Masaru; Sawada, Tokunosuke; Kozuka, Mutsuo; Hamano, Daisuke; Yoshimura, Katsumi

doi:10.1248/yakushi1947.89.5_737

Cited by 26 publications

(13 citation statements)

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“…Fax: +81(86)-235-7492 E-mail: dr-mori@cc.okayama-u.ac.jp [16], strychnilactone [17], strychnistenolide and its acetate [18], and alkaloids [19,20]. The well-known Uyaku compounds mentioned above, and other sesquiterpenes such as isolinderalactone, neolinderalactone, lindestrenolide lindenone, linderazulene, chamazulene, laurolitsine, isogermafurene have been summarized in previous other studies [2][3][4][5].…”

Section: Tel: +81-(86)-235-7491mentioning

confidence: 99%

Antioxidant Activities of Uyaku (Lindera Strychnifolia) Leaf Extract: A Natural Extract Used in Traditional Medicine

Noda

Mori

2007

J. Clin. Biochem. Nutr.

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Summary Uyaku (Lindera strychnifolia, Sieb. et Zucc.) is used in traditional Asian medicine to treat stomach and renal diseases, neuralgia, rheumatism, and aging. In this study, the effects of lyophilized extracts on hydroxyl (˙OH) and superoxide (O2˙−) radicals were examined using an electron spin resonance (ESR) spectrometer with the spin trap, 5,5'-dimethyl-1-pyrroline-N-oxide. Inhibitory effects were assessed using the following reagents: for nitric oxide (NO˙), the Griess reagent; for (Fe 2+ + H2O2)-induced lipid peroxidation, 2-thiobarbituric acid; for (Fe 2+ + H2O2)-induced protein carbonyl, 2,4-dinitrophenylhydrazine. Analysis of ESR data of the extracts indicated the direct ˙OH and O2˙− scavenging. The extracts scavenged NOi n a dose-dependent manner, inhibited lipid peroxidation of linolenic acid, and protein carbonyl formation in bovine serum albumin. In conclusion, the Uyaku leaf hot-water extract has potent scavenging activity against reactive oxygen species and reactive nitrogen species, and effectively inhibited lipid peroxidation. These results might contribute to understanding ageassociated or free radical-related diseases induced by excess reactive oxygen and also nitrogen species.

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Section: Tel: +81-(86)-235-7491mentioning

confidence: 99%

Antioxidant Activities of Uyaku (Lindera Strychnifolia) Leaf Extract: A Natural Extract Used in Traditional Medicine

Noda

Mori

2007

J. Clin. Biochem. Nutr.

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“…The main components of Radix Linderae include sesquiterpenes, sesquiterpene lactones, essential oils [8,9], alkaloids [10,11], flavonoids [12], lignans and condensed tannins [13,14], some of the sesquiterpene lactones and alkaloids have been considered to be characteristic and active constituents and are used as index components for the quality standard of Radix Linderae in Chinese Pharmacopoeia and some articles through quantitative analysis [15][16][17]. The alkaloids in Radix Linderae have showed potential antitumor, antidiabetic, anti-inflammatory, antiviral and antimicrobial activities [18,19].…”

Section: Introductionmentioning

confidence: 99%

Development of the fingerprint for the quality of Radix Linderae through ultra‐pressure liquid chromatography‐photodiode array detection/electrospray ionization mass spectrometry

Zheng

Luan

et al. 2010

J of Separation Science

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An ultra-performance LC in combination with MS/MS method was established to evaluate the quality of wu-yao (the dried root of Lindera aggregata (Sims) Kosterm. (Lauraceae)) through simultaneous quantitation of five sesquiterpene lactones, linderagalactone D (1), linderagalactone C (2), hydroylindestenolide (3), neolinderalactone (4) and linderane (5). All compounds were separated on a Waters Acquity ultra-performance LC HSS T3 column (2.1 mm x 100 mm, 1.8 microm particle size) with linear gradient elution of acetonitrile and 0.1% formic acid. An ESI interface in the positive mode was employed prior to MS detection. All the compounds showed good linearity (R(2)> or = 0.9992). The recoveries, measured at three concentration levels, varied from 97.3 to 103.4% with RSDs < 4.8%. The simple, rapid and reliable method was successfully applied to quantify the five components in 13 samples of wu-yao from different areas.

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“…In present-day Japan, Lindera strychnifolia are growing naturally in Shingu (Wakayama, Japan), and water extract of the root of this plant has been used as acesodyne, antispasmodic and diuretic in folk medicine. In previous studies on the constituents of this plant, many sesquiterpenes (Takeda et al, 1963(Takeda et al, , 1968Kobayashi et al, 2002) and alkaloids (Kozuka et al, 1984;Tomita et al, 1969) have been isolated from the root. However, the pharmacological study of these isolated compounds and this plant is rare.…”

Section: Introductionmentioning

confidence: 99%

Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice

et al. 2005

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The Alkaloids of Lindera strychnifolia (SIEB. et ZUCC.) F. VILL. and Lindera umbellata THUNB.

Cited by 26 publications

References 0 publications

Antioxidant Activities of Uyaku (Lindera Strychnifolia) Leaf Extract: A Natural Extract Used in Traditional Medicine

Antioxidant Activities of Uyaku (Lindera Strychnifolia) Leaf Extract: A Natural Extract Used in Traditional Medicine

Development of the fingerprint for the quality of Radix Linderae through ultra‐pressure liquid chromatography‐photodiode array detection/electrospray ionization mass spectrometry

Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice

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