Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice

Ohno, Takamasa; Takemura, Genzou; Murata, Ichijiro; Kagawa, Tomoyo; Akao, Seigo; Minatoguchi, Shinya; Fujiwara, Takako; Fujiwara, Hisayoshi

doi:10.1016/j.lfs.2005.04.018

Cited by 43 publications

(29 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some researchers reported the amelioration of glomerulosclerosis with use of root extract of lindera strychnifolia (28), extract of aerial parts of Aster koraiensis (29), SKEO (26) and rosmarinic acid (27). There are reports that glomerulosclerosis inhibited or decreased by Vit C, alpha lipoic acid, Vit E (30-32) and ferolic acid, a polyphenolic antioxidant in diabetic rats (33).…”

Section: Results From Antioxidant Therapy In Experimental Diabetic Nementioning

confidence: 99%

Diabetic nephropathy and antioxidants

Tavafi¹

2013

J Nephropathol

132

View full text Add to dashboard Cite

Section: Results From Antioxidant Therapy In Experimental Diabetic Nementioning

confidence: 99%

Diabetic nephropathy and antioxidants

Tavafi¹

2013

J Nephropathol

132

View full text Add to dashboard Cite

“…The root tuber protein of Richosanthes kirilowii suppressed the HSV-1 infection by targeting the mitogen-activated protein kinase (MAPK) family pathway [27]. Water extract of the root of Lindera strychnifolia slowed down the progression of diabetic nephropathy in db/db mice [28]. Citrus fruits were found to be a potentially important source of anti-inflammatory flavonoids in the human diet [29].…”

Section: Resultsmentioning

confidence: 99%

Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro

et al. 2007

View full text Add to dashboard Cite

Bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. Bone resorption and loss are generally attributed to osteoclasts. Differentiation of osteoclasts is regulated by receptor activator of nuclear factor NF-kB ligand (RANKL), a member of tumor necrosis factor family. When the balance is disturbed, pathological bone abnormality ensues. Through the screening of traditional Korean medicinal plants, the effective molecules for inhibition and stimulation of RANKL-induced osteoclast differentiation in mouse bone marrow macrophages were identified. Among 222 methanol extracts, of medicinal plants, 10 samples exhibited ability to induce osteoclast differentiation. These include Dryobalanops aromatica, Euphoria longana, Lithospermum erythrorhizon, Prunus mume, Prunus nakaii, and Polygonatum odoratum. In contrast, Ailanthus altissima, Curcuma longa, Solanum nigrum, Taraxacum platycarpa, Trichosanthes kirilowii, and Daphne genkwa showed inhibitory effects in RANKLinduced osteoclast differentiation.

show abstract

“…Recent studies demonstrated that Uyaku extract has antiviral activity [21], an inhibitory effect on prolyl endopeptidase [22], and is associated with anticancer activity in lungs [23]. It has also a potentially protective effect against post-ischemic myocardial dysfunction [24], and diabetic nephropathy [25]. In a previous study, we examined whether the water-soluble components of Uyaku leaves have antioxidant activity, and found that root and leaf extracts by hot-water extraction have specific and potent superoxide anion radical scavenging activity as well as several other natural extracts [26].…”

Section: Tel: +81-(86)-235-7491mentioning

confidence: 99%

Antioxidant Activities of Uyaku (Lindera Strychnifolia) Leaf Extract: A Natural Extract Used in Traditional Medicine

Noda

Mori

2007

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

Summary Uyaku (Lindera strychnifolia, Sieb. et Zucc.) is used in traditional Asian medicine to treat stomach and renal diseases, neuralgia, rheumatism, and aging. In this study, the effects of lyophilized extracts on hydroxyl (˙OH) and superoxide (O2˙−) radicals were examined using an electron spin resonance (ESR) spectrometer with the spin trap, 5,5'-dimethyl-1-pyrroline-N-oxide. Inhibitory effects were assessed using the following reagents: for nitric oxide (NO˙), the Griess reagent; for (Fe 2+ + H2O2)-induced lipid peroxidation, 2-thiobarbituric acid; for (Fe 2+ + H2O2)-induced protein carbonyl, 2,4-dinitrophenylhydrazine. Analysis of ESR data of the extracts indicated the direct ˙OH and O2˙− scavenging. The extracts scavenged NOi n a dose-dependent manner, inhibited lipid peroxidation of linolenic acid, and protein carbonyl formation in bovine serum albumin. In conclusion, the Uyaku leaf hot-water extract has potent scavenging activity against reactive oxygen species and reactive nitrogen species, and effectively inhibited lipid peroxidation. These results might contribute to understanding ageassociated or free radical-related diseases induced by excess reactive oxygen and also nitrogen species.

show abstract

Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice

Cited by 43 publications

References 31 publications

Diabetic nephropathy and antioxidants

Diabetic nephropathy and antioxidants

Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro

Antioxidant Activities of Uyaku (Lindera Strychnifolia) Leaf Extract: A Natural Extract Used in Traditional Medicine

Contact Info

Product

Resources

About