The Alkaloids of Argemone Mexicana

Santos, Alfredo C.; Adkilen, Pacifica

doi:10.1021/ja01346a037

Cited by 28 publications

(8 citation statements)

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“…1) is a natural plant alkaloid abundantly distributed in the plants like Sanguinaria canadensis and Chelidonium majus. [1][2][3][4][5] Sanguinarine has been the focus of extensive research for its potential drug value. In recent years considerable research on its antimicrobial, antifungal, antioxidant and anti-inammatory effects, [6][7][8][9][10] and ability for selective/ preferential elimination of cancer cells has been undertaken.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties of inclusion complexes of sanguinarine with natural cyclodextrins: spectroscopy, calorimetry and NMR studies

Hazra

Kumar

2015

RSC Adv.

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The supramolecular interactions for the formation of inclusion complexes of sanguinarine with a-, b-, and g-cyclodextrins (CDs) were studied by UV-vis absorbance, fluorescence, circular dichroism and proton nuclear magnetic resonance spectroscopy, and isothermal titration calorimetry. The results revealed that sanguinarine binds with the three natural CDs in 1 : 1 stoichiometry. The binding affinity followed the order b > a > g-CDs; the affinity to b-CD was the highest compared to the other two CDs apparently due to the perfect cavity size for the inclusion of sanguinarine into the b-CD cavity. The association of sanguinarine with a-, and b-CDs is synergistically driven by a greater entropy contribution to the Gibbs energy of the association, whereas it was favoured by both enthalpy and entropy contributions for the g-CD. The NMR study indicated that encapsulation of sanguinarine in a-, and b-CDs, involves partial inclusion and to g-CD it is non-specific and complete inclusion i.e., both ends of sanguinarine, can be included into the CD cavity.

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Section: Introductionmentioning

confidence: 99%

Physicochemical properties of inclusion complexes of sanguinarine with natural cyclodextrins: spectroscopy, calorimetry and NMR studies

Hazra

Kumar

2015

RSC Adv.

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“…The alkaloids were quantitatively estimated by the method described by Alfred0 Santos (8). Much variation was observed from sample to sample, but the average total alkaloidal content was 0.125y0.…”

Section: Methodsmentioning

confidence: 99%

Chemical and pharmacological studies on Argemone mexicana

Bose

Vijayvargiya

Saifi

et al. 1963

Journal of Pharmaceutical Sciences

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“…Whole plant and seeds are the most extensively screened parts of A. mexicana. The alkaloids berberine and protopine (Santos and Adkilen 1932;Bose et al 1963;Chang et al 2003a) are the two major phytochemicals present in the A. mexicana. Whole plant: Phytochemicals identified from the whole plant include norsanguinarine, norchelerythrine, cryptopine, (À)-cheilanthifoline, (À)-β-scoulerine methohydroxide, and (À)-α-& β-stylopine methohydroxide (Haisova and Slavik 1975); isoquinolone: oxyhydrastinine (Hussain et al 1983); protopine: argemexicaine A, argemexicaine B, and allocryptopine; benzo(c) phenanthridines: (AE)-6-acetonyldihydrochelerythrine, norchelerythrine, O-methylzanthoxyline, sanguinarine, (AE)-6-acetonyldihydrosanguinarine, arnottianamide, (À)-angoline, and chelerythrine; protoberberine type alkaloids: (À)-tetrehydroberberine, dehydrocheilantifoline (Chang et al 2003a); alkaloids: tannic, caffeic, ferulic acids (Singh et al 2010a); quaternary isoquinoline alkaloids: dehydrocorydalmine, jatrorrhizine, columbamine, and oxyberberine (Singh et al 2010b); benzylisoquinoline alkaloid: argemexirine; protoberberine alkaloids: DL-tetrahydrocoptisine and dihydrocoptisine (Singh et al 2010c).…”

Section: Phytochemistrymentioning

confidence: 99%