The airway cholinergic system: physiology and pharmacology

Racké, Kurt; Matthiesen, Sonja

doi:10.1016/j.pupt.2004.03.001

Cited by 122 publications

(116 citation statements)

References 243 publications

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“…The mAChRs are involved in a variety of physiological processes, and abnormal muscarinic signaling has been implicated to participate in many diseases, from chronic obstructive pulmonary disease (34) to (neuro)degenerative diseases (35)(36)(37), among others. Therefore, efforts are directed in research aiming to identify pharmacological compounds selective for each muscarinic receptor subtype.…”

Section: Resultsmentioning

confidence: 99%

The snake venom peptide Bj‐PRO‐7a is a M1 muscarinic acetylcholine receptor agonist

et al. 2010

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Proline-rich peptides from Bothrops jararaca venom (Bj-PRO) were characterized based on the capability to inhibit the somatic angiotensin-converting enzyme. The pharmacological action of these peptides resulted in the development of Captopril, one of the best examples of a target-driven drug discovery for treatment of hypertension. However, biochemical and biological properties of Bj-PROs were not completely elucidated yet, and many recent studies have suggested that their activity relies on angiotensinconverting enzyme-independent mechanisms. Here, we show that Bj-PRO-7a (

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Section: Resultsmentioning

confidence: 99%

The snake venom peptide Bj‐PRO‐7a is a M1 muscarinic acetylcholine receptor agonist

et al. 2010

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“…Indeed, acetylcholine by binding to its muscarinic type receptors on heart, could cause, negative inotropic and chronotropic effects (Felder, 1995;Bois et al, 1999;Roffel et al, 2001;Racke and Matthiesen, 2004;Gerova et al, 2005;Hirota and McKay, 2006) and the vasorelaxation by releasing nitric oxide (NO) by endothelium (Furchgott and Zawadzki, 1980;Zapol et al, 1994;Ducrocq et al, 2001;Zhao et al, 2004;Lamblin et al, 2005;Collin and Levy, 2008;Jeanneret, Sanchez, Liaudet, 2011).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and Toxicological Studies of an Extract of the Seeds of Picralima Nitida (Stapf) (Apocynaceae) and Its Pharmacological Effects on the Blood Pressure of Rabbit

N’dri

Nene-Bi

Zahoui

et al. 2015

JBLS

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The phytochemical screening of the seeds extracts of Picralima nitida has highlighted the presence of alkaloids and terpenes poly sterols in chloroform solutions, methanol and in the aqueous. Unlike chloroform and methanol solutions, the aqueous revealed the presence of saponins. An acute toxicity study in mice showed that the aqueous extract of Picralima nitida would be slightly toxic with a lethal dose (LD) 50 % of 9120.11 mg/kg of body weight (bw). This extract, in rabbits induced a dose-dependent hypotension for the doses between 3.10 -6 g / kg bw and 2.10 -5 g/kg bw with an effective dose 50% (ED50) equal to 4.07×10 -6 g/kg bw. In the presence of atropine (6.10 -9 g/kg), a competitive inhibitor of acetylcholine, the hypotensive effect of aqueous extract of Picralima nitida is reduced, confirming in this extract the presence of cholinomimetics substances of muscarinic type. The results therefore suggest the presence of cholinomimetics substances in the aqueous extract of Picralima nitida seed. These substances could be responsible for the hypotensive effect of this extract. The same extract did not induce diuresis in rats.

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“…Tracheal smooth muscle strips were pre-incubated for 30 min with ODQ (1H- [1,2,4 ] Oxadiazolo [4,3-a]quinoxalin-1-one) (■) (100 nM) selective inhibitor of NO-sGC, following the Procedure 2 as described in reference 36. Control experiments (□) without drug were run simultaneously under the same conditions.…”

Section: Body: Cyclic Gmp Signals During Muscarinic Activationmentioning

confidence: 99%

“…Statistically significant difference between the Control with respect to mastoparan as indicated with asterisk (*p<0.05). Thus, a dysfunction of these M2/M3AChR signal transducing cascades has been implied in the pathophysiological mechanisms of bronchial asthma as mentioned in references [1,3,4] and Chronic Obstructive Pulmonary Disease (COPD) in [3]. In this sense, we attempted to evaluate these novel signal transducing cascades involving guanylyl cyclase activities above discussed, in an experimental asthma model in rats as described in reference [70].…”

Section: Body: Cyclic Gmp Signals During Muscarinic Activationmentioning

confidence: 99%

“…Acetylcholine (Ach) is the predominant parasympathetic neurotransmitter, acting as an autocrine or paracrine hormone in the airways and its role in the regulation of bronchomotor tone and mucus secretion from airway submucosal glands in the respiratory tract is well established as described in [2]. More recent findings suggest that acetylcholine regulates additional functions in the respiratory tract, may promoting airway inflammation and remodelling, including airway smooth muscle thickening in inflammatory lung diseases as reported in references [3][4][5]. Another source of ACh is the non-neuronal cells and tissues, particularly inflammatory cells and the airway epithelium as described in references [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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