The agouti coat-color locus may influence brain catecholamines: Regional differences in norepinephrine and dopamine in the brains of two color-morphs of deermice (Peromyscus maniculatus)

Hayssen, Virginia; Gunawardhana, S.; Meyer, Jerrold S.

doi:10.1016/1367-8280(94)90009-4

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Agouti and nonagouti deer mice have different neural profiles of catecholamines (Hayssen, Gunawardhana, & Meyer, 1994), especially in the mid- and hind brain. Neural MSH is located primarily in the pituitary and the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

Effects of the nonagouti coat-color allele on behavior of deer mice (Peromyscus maniculatus): A comparison with Norway Rats (Rattus norvegicus).

Hayssen¹

1997

Journal of Comparative Psychology

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The agouti locus influences coat color by antagonizing melanocyte-stimulating hormone (MSH) at its receptor on pigment cells and may antagonize MSH in neural tissue. This study replicates work on rats to assess whether behavioral (neural) effects of the agouti locus are as similar across mammals as those on coat color. Handling, open-field, platform jump, and food-novelty tests were conducted on agouti and nonagouti deer mice (Peromyscus maniculatus) following protocols in C. A. Cottle and E. O. Price (1987). As with rats, nonagouti deer mice were less aggressive, less active, and easier to handle compared with their agouti counterparts. Nonagouti deer mice also groomed more than agouti subjects. Thus, behavioral effects of the agouti locus are conservative, and agouti may be an important modulator of melanocortins in neural as well as integumentary tissue.

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Section: Discussionmentioning

confidence: 99%

Effects of the nonagouti coat-color allele on behavior of deer mice (Peromyscus maniculatus): A comparison with Norway Rats (Rattus norvegicus).

Hayssen¹

1997

Journal of Comparative Psychology

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“…However, at present, we do not know exactly why the loss of the agouti protein induced tamed behaviour in MSM/Ms mice. The agouti protein is also found in the brain and is an antagonist of the melanocyte-stimulating hormone (MSH) at its receptor in neural tissues 24 25 26 . Gene expression analysis by microarray and RT-qPCR revealed that the Slc6a3 gene, a dopamine transporter gene, was significantly more up-regulated in the midbrain of KO mice than in that of WT mice.…”

Section: Discussionmentioning

confidence: 99%

CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene

Hirose

Hasegawa

Mochida

et al. 2017

Sci Rep

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Wild-derived mice have contributed to experimental mouse genetics by virtue of their genetic diversity, which may help increase the chance of identifying novel modifier genes responsible for specific phenotypes and diseases. However, gene targeting using wild-derived mice has been unsuccessful because of the unavailability of stable embryonic stem cells. Here, we report that CRISPR/Cas9-mediated gene targeting can be applied to the Japanese wild-derived MSM/Ms strain (Mus musculus molossinus). We targeted the nonagouti (a) gene encoding the agouti protein that is localized in hair and the brain. We obtained three homozygous knockout mice as founders, all showing black coat colour. While homozygous knockout offspring were physiologically indistinguishable from wild-type litter-mates, they showed specific domesticated behaviours: hypoactivity in the dark phase and a decline in the avoidance of a human hand. These phenotypes were consistent over subsequent generations. Our findings support the empirical hypothesis that nonagouti is a domestication-linked gene, the loss of which might repress aggressive behaviour.

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“…reproductor (Galea et al, 1994;Jaquot y Vessey, 1994), genético (Cowling et al 1994;Crew et al 1994) y en neurociencias (Hayssen et al, 1994;Sucheki et al, 1995).…”

Section: Justificaciónunclassified

Estudio sobre algunos aspectos de la biología de la reproducción de Peromyscus winkelmanni

Lorenzana

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The agouti coat-color locus may influence brain catecholamines: Regional differences in norepinephrine and dopamine in the brains of two color-morphs of deermice (Peromyscus maniculatus)

Cited by 4 publications

References 22 publications

Effects of the nonagouti coat-color allele on behavior of deer mice (Peromyscus maniculatus): A comparison with Norway Rats (Rattus norvegicus).

Effects of the nonagouti coat-color allele on behavior of deer mice (Peromyscus maniculatus): A comparison with Norway Rats (Rattus norvegicus).

CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene

Estudio sobre algunos aspectos de la biología de la reproducción de Peromyscus winkelmanni

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