The Aging Kidney Phenotype and Systemically Derived Stem Cells

Striker, Gary E.

doi:10.1681/asn.2011090946

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…Accumulated studies have shown that aging is an independent risk factor for the onset and development of renal diseases 33 34 . DR can extend the lifespan or delay the aging process by decreasing oxidative stress level 35 36 37 .…”

Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats

Wang

Cai

Ning

et al. 2016

Sci Rep

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Renal aging is always accompanied by increased oxidative stress. Hydrogen sulfide (H2S) can be up-regulated by 50% dietary restriction (DR) for 7-day and can block mitochondrial oxidative stress. H2S production exerts a critical role in yeast, worm, and fruit fly models of DR-mediated longevity. In this study, we found that renal aging could be attenuated by 30% DR for 6-month (DR-6M) and life-long (DR-LL), but not for 6-week (DR-6W). The expressions of cystathionine-γ-lyase (CGL) and cystathionine-β- synthase (CBS) were improved by DR-6M and DR-LL. Endogenous H2S production shared the same trend with CBS and CGL, while glutathione (GSH) didn’t. When comparing efficiencies of DR for different durations, more evident production of H2S was found in DR-6M and DR-LL than in DR-6W. Finally the level of oxidative stress was improved by DR-6M and DR-LL rather than by DR-6W. It concluded that aged rats had the ability to produce enough H2S on 30% DR interventions protecting against renal aging, and the effect of DR for long-term were more significant than that of DR for short-term.

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Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats

Wang

Cai

Ning

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…It has also been demonstrated both in vitro and in vivo , in animal models and in humans with respect to the biological functions 4,5 . Several studies demonstrated that the administration of bone marrow‐derived MSC may protect or reverse both AKI and CKD, as well as in other experimental models 9,10,13–19 . The effects of MSC transplantation might be explained by paracrine roles from the transplanted cells, because no strong evidence has been presented that transplanted MSC truly trans‐differentiate into cell populations specific to the injured organ until now.…”

Section: Discussionmentioning

confidence: 99%

“…There were also abundant applications of MSC in the treatment of kidney diseases, which could prevent the process of deterioration or reduce the injury following toxic/ischaemic events, as well as other repair mechanisms 9–12 . The research mentioned above includes many different models of injuries, different routes and doses of administration, showing that treatment with exogenous MSC ameliorates acute kidney injury (AKI) 10,13–15 and chronic kidney disease (CKD) 9,16–19 . Therefore, we have reasons to believe that the MSC has a broad research and application prospects, although the exact mechanisms underlying these effects remain largely unknown till now.…”

mentioning

confidence: 99%