The Aging Fat Cell

Remacle, Claude; Hauser, N.

doi:10.1111/j.1532-5415.1989.tb06684.x

Cited by 5 publications

(3 citation statements)

References 248 publications

(287 reference statements)

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“…Taken together, the results presented in this paper and found in the literature [11,18,20,21] suggest that the increase in lipogenic enzyme activities in residual fat pads may be due to: (a) the decrease in serum (tissue) leptin concentration, (b) the increase in insulin sensitivity, or (c) the decrease in the amount of fat pads. It is not excluded that the increase of lipogenic activity of remnant adipose tissue after surgical removal of the majority of abdominal fat represents a compensatory response to the diminished amount of fat pads.…”

Section: Discussionsupporting

confidence: 50%

“…Thus, it is unlikely that total body weight may influence the lipogenic enzymes activities. Considering that the size and fat content of adipocytes are important determinants of lipid metabolism [18] , one can conclude that the decrease in fat pad size (due to the surgical removal of more than 90% of abdominal adipose tissue), apart from the regulation of plasma leptin concentration, may also influence lipogenic enzyme activity.…”

Section: Discussionmentioning

confidence: 99%

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Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Nogalska

Stelmańska²,

Śledziński³

et al. 2008

Gerontology

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Background: The rate of lipogenesis and gene expression of lipogenic enzymes in white adipose tissue (WAT) of rats decreases with age. Previously, we showed the inverse relationship between serum leptin concentration and lipogenic enzymes activities in WAT of ageing rats. Based on those results, we postulated that leptin could play some role in the downregulation of lipogenic enzyme genes expression in WAT of old rats. Objective: To further test this hypothesis, in the present paper we examined the effect of surgical removal of perirenal and epididymal WAT on serum leptin concentration and lipogenic enzymes activities in remnant adipose tissue of old rats. Methods: One-year-old rats, which display a high serum leptin concentration and low lipogenic enzyme activities in WAT, were subjected to surgical removal of the perirenal and epididymal WAT. Two months after the surgery, the serum leptin concentration and lipogenic enzyme activities in remnant WAT were compared to the serum leptin concentration and lipogenic enzyme activities measured in adipose tissue collected during the surgery. Results: WAT removal resulted in an approximately 6-fold decrease of serum leptin concentration and about a 2-fold increase of lipogenic enzyme activities in remnant adipose tissue. Conclusions: These results indicate that interventions designed to reduce abdominal adipose tissue mass can change the lipogenic activity of remnant adipose tissue. Additionally, leptin could be one of the factors contributing to the downregulation of the genes expression of lipogenic enzymes during ageing in rats.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Nogalska

Stelmańska²,

Śledziński³

et al. 2008

Gerontology

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show abstract

“…The increase in ob gene expression at the first phase (between 1 and 3 month old rats) could be related, at least in part, to the increase in food intake by the rats [37]. However, these changes might also be related to the development or simply be secondary to differences in the amount of fat pads appearing in rats at different ages, since the size of fat cells and fat content of adipocytes are important determinants of lipid metabolism [38]. Leptin, FA and triglyceride synthesize by increasing the intracellular lipid concentration, reducing or directly inhibiting lipid oxidation.…”

Section: Discussionmentioning

confidence: 99%