The affinity of bone to hydroxyapatite and alumina in experimentally induced osteoporosis

Hayashi, Kazuo; Uenoyama, Kazuhide; Matsuguchi, Nobuyuki; Nakagawa, Shizue; Sugioka, Yôichi

doi:10.1016/s0883-5403(89)80022-1

Cited by 45 publications

(14 citation statements)

References 16 publications

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“…[27][28][29] Søballe et al 30 studied the ingrowth of osteopenic bone into titanium-alloy porous-coated implants with and without HA coating in dogs and concluded that HA-coated implants were not affected by the osteopenic condition. This is the only report in which the integrity between an HA-coated implant and osteoporotic bone has been evaluated mechanically.…”

Section: Discussionmentioning

confidence: 99%

The effect of hydroxyapatite coating on the bonding of bone to titanium implants in the femora of ovariectomised rats

Hara¹,

Hayashi

Nakashima³

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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We have studied the effect of hydroxyapatite (HA) coating in 15 ovariectomised and 15 normal rats which had had a sham procedure. Twenty-four weeks after operation, HA-coated implants were inserted into the intramedullary canal of the right femur and uncoated implants into the left femur. The prostheses were removed four weeks after implantation. Twelve specimens in each group had mechanical push-out tests. Sagittal sections of the other three were evaluated by SEM.The bone mineral density (BMD) of the dissected left tibia was measured by dual-energy x-ray absorptiometry. The difference in BMD between the control and ovariectomised tibiae was 35.01 mg/cm 2 (95% CI, 26.60 to 43.42). The push-out strength of the HA-coated implants was higher than that of the uncoated implants in both groups (p < 0.0001), but the HA-coated implants of the ovariectomised group had a reduction in push-out strength of 40.3% compared with the control group (p < 0.0001).Our findings suggest that HA-coated implants may improve the fixation of a cementless total hip prosthesis but that the presence of osteoporosis may limit the magnitude of this benefit. [Br] 1999;81-B:705-9. J Bone Joint Surg Received 26 May 1998; Accepted after revision 4 November 1998Many studies have used animal models to demonstrate the osteoconductive properties of bioactive ceramics, especially hydroxyapatite (HA). Recently, HA-coated implants have been used in total hip replacement (THR), and early clinical results suggest that HA-coated prostheses are an attractive alternative to standard methods of cementless arthroplasty.1-6 The animals used in basic studies on the properties of HA coating had a normal bone metabolism and bone mass. 4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In such animals, the formation and resorption phases of bone are tightly coupled, and bone mass is maintained. We believe, however, that many patients, especially women, who undergo THR, have uncoupling of the phases of bone remodelling and decreased bone mass. 22 Our aim was to confirm the efficiency of HA in osteoporotic conditions and we have studied the bone-implant attachment strength of HA-coated titanium implants in ovariectomised and normal rats. Materials and MethodsExperimental design and operative procedure. We used thirty 12-week-old female Wistar King rats weighing between 243 and 282 g. They were housed and tested at the Institute of Laboratory Animals, Faculty of Medicine, Kyushu University. All the rats were sedated with ether and anaesthetised by peritoneal administration of pentobarbital (40 mg/kg body-weight). They were then divided into two groups. One had bilateral ovariectomy using standard veterinary procedures and the other a sham operation which consisted of exposure and palpation of the ovaries without removal. At 24 weeks after this operation HA-coated and uncoated implants were inserted into the medullary canal of the right and left femora, respectively, in both groups, after reaming the intercondylar notch of each distal femur with a 1.5 mm dri...

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Section: Discussionmentioning

confidence: 99%

The effect of hydroxyapatite coating on the bonding of bone to titanium implants in the femora of ovariectomised rats

Hara¹,

Hayashi

Nakashima³

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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“…The affinity index of each section was calculated by dividing this length by the total length of the bone-cement interface and multiplying by 100. 28,33 Mechanical testing A method of the push-out test was described in detail in our previous report. 28 Briefly, the cement and femoral component were pushed together with a metal rod 6 mm in diameter at a crosshead speed of 0.5 mm per min, using an Instron-type testing machine (Autograph Model AG-10TG, Shimazu, Kyoto, Japan).…”

Section: Affinity Indexmentioning

confidence: 99%

Evaluation of bioactive bone cement in canine total hip arthroplasty

Fujita¹,

Ido²,

Matsuda³

et al. 2000

J. Biomed. Mater. Res.

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Total hip arthroplasties (THAs) were performed in beagle dogs using a bioactive bone cement (BABC) consisting of a silane-treated apatite- and wollastonite-containing glass-ceramic (AW glass-ceramic) powder and a silica glass powder as the filling particles and a bisphenol-A-glycidyl dimethacrylate-based resin (Bis-GMA-based resin) as the organic matrix. The outcomes were compared with the results of polymethylmethacrylate (PMMA) bone cement. The mechanical properties of the BABC were stronger than those of PMMA bone cement. The bonding strength of the BABC to bone in the dogs' femora increased with time and reached 3.7 MPa at 24 months after implantation whereas that of PMMA bone cement was 2.0 MPa (p < 0.05). Histological examination showed direct bonding between the BABC and the femoral bone for up to 24 months after implantation. However, with PMMA bone cement an intervening soft-tissue layer consistently was observed at the bone-cement interface. Direct bonding at the interface between the BABC and the bone through a calcium phosphorous layer 30 microm-thick was revealed by scanning electron microscopy. Femoral bone resorption was observed at 24 months after implantation in the BABC group, but it was not observed in the PMMA bone cement group. Direct bonding between BABC and the bone may have accelerated femoral bone resorption. Cement fractures of the BABC were observed on the acetabular side 24 months after implantation. Weak bonding between the BABC and an acetabular component made of ultrahigh molecular weight polyethylene (UHMWPE), relatively high elastic characteristics of BABC, and weakness of the calcium phosphorous layer formed on the surface of this cement seemed to lead to failure at 24 months on the acetabular side.

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“…1,[7][8][9][10][11] Some reports suggest that implants are prone to failure as a result of the diminished capacity for bone remodeling, and hence osseointegration and biomechanical maintenance of the implant, within osteoporotic bone, 12,13 whereas other reports have promoted the use of dental implants in the edentulous mandible to minimize physiological and age-related bone loss. 9,14,15 Several studies using either administration of glucocorticoids or ovariectomized animal models have been conducted to address the concerns of implant use under experimentally induced osteoporotic-like conditions. 12,16 -19 The aim of this study was to determine the level of implant osseointegration in osteoporotic-like bone using an ovariectomized rat animal model.…”

mentioning

confidence: 99%

Examination of the Bone???Implant Interface in Experimentally Induced Osteoporotic Bone

Cho

Schneider²,

Krizan³

et al. 2004

Implant Dentistry

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The affinity of bone to hydroxyapatite and alumina in experimentally induced osteoporosis

Cited by 45 publications

References 16 publications

The effect of hydroxyapatite coating on the bonding of bone to titanium implants in the femora of ovariectomised rats

The effect of hydroxyapatite coating on the bonding of bone to titanium implants in the femora of ovariectomised rats

Evaluation of bioactive bone cement in canine total hip arthroplasty

Examination of the Bone???Implant Interface in Experimentally Induced Osteoporotic Bone

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