Examination of the Bone???Implant Interface in Experimentally Induced Osteoporotic Bone

Cho, Peter; Schneider, Galen B.; Krizan, K. E.; Keller, John C.

doi:10.1097/01.id.0000116456.76235.bc

Cited by 59 publications

(48 citation statements)

References 24 publications

(16 reference statements)

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“…In addition, we noted the presence of trabecular bone in the implanted areas of group BOHR. Similar results have been reported by (Cho et al, 2004;Cunha et al, 2010), who studied the boneimplant interface in ovariectomized rats. The authors concluded that osteoporosis-like conditions induced by hormone deficiency might compromise the mechanical stability of the implant in view of the results demonstrating a reduction of the cortical layer and an increase of trabecular bone in the recipient area.…”

Section: Discussionsupporting

confidence: 78%

“…These findings suggest the influence of estrogen on both the process of osteogenesis and the type of new bone. Similar results have been reported by (Cho et al, 2004), who studied the bone-dental implant interface in ovariectomized rats and observed a reduction of the cortical layer and an increase of trabecular bone in the recipient area. The authors concluded that osteoporosis induced by estrogen deficiency might compromise the mechanical stability of the implant area.…”

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Ribeiro

Figueira

Issa

et al. 2011

Microscopy Res & Technique

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2012Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats MICROSCOPY RESEARCH AND TECHNIQUE, MALDEN, v. 75, n. 2, pp. 133-137, FEB, 2012 http://www.producao.usp.br/handle/BDPI/42523 ABSTRACT Osteoporosis is a global public health that affects postmenopausal women due to the deficiency of estrogen, a hormone that plays an important role in the microarchitecture of bone tissue. Osteoporosis predisposes to pathological bone fracture that can be repaired by conventional methods. However, depending on the severity and quantity of bone loss, the use of autogenous grafts or biomaterials such as hydroxyapatite might be necessary. The latter has received increasing attention in the medical field because of its good biological properties such as osteoconductivity and biocompatibility with bone tissue. The objective of this study was to evaluate using histologic and radiographic analyses, the osteogenic capacity of hydroxyapatite implanted into the femur of rats with ovariectomy-induced osteoporosis. Eighteen rats were divided into three groups with six animals in each: group nonovariectomized, bilaterally ovariectomized not receiving estrogen replacement therapy, and bilaterally ovariectomized submitted to estrogen replacement therapy. Defects were created experimentally in the distal epiphysis of the femur with a surgical drill and filled with porous hydroxyapatite granules. The animals were sacrificed 8 weeks after surgery. The volume of newly formed bone in the implant area was quantified by morphometrical methods. The results were analyzed by ANOVA followed by the Tukey test (P < 0.05). The hydroxyapatite granules showed good radiopacity. Histological analysis revealed less quantity of newly formed bone in the ovariectomized group not submitted to hormone replacement therapy. In conclusion, bone neoformation can be expected even in bones compromised by estrogen deficiency, but the quantity and velocity of bone formation are lower. Microsc. Res. Tech. 75:133-137, 2012. V

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 77%

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Ribeiro

Figueira

Issa

et al. 2011

Microscopy Res & Technique

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“…Von Wower et al [5] demonstrated that BMD is significantly lower in the oral cavity of patients with systemic osteoporosis than in normal subjects. In contrast, Wakley et al [6] believe that the existence of osteoporosis in the axial or appendicular skeleton does not indicate the presence of the disease in the region of the maxilla or mandible, and if the disease is present, it does not predict an unfavorable outcome of dental implants [7,8].…”

Section: Introductionmentioning

confidence: 99%

Comparative study of axial and femoral bone mineral density and parameters of mandibular bone quality in patients receiving dental implants

et al. 2007

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Introduction: In view of the increase in the life expectancy of humans and in edentulism of the population above 50 years of age, in which the prevalence of osteoporosis is also higher, it is fundamental to better understand the effects of systemic bone mass loss on the healing process of dental implants and to determine the quality of the bone that surrounds them. The objective of the present study was to compare systemic osteoporosis (axial and femoral) and parameters of mandibular bone quality, and to evaluate osseointegration in postmenopausal women receiving dental implants. Methods: The sample consisted of 39 women aged 48-70 years, 19 with a densitometric diagnosis of osteoporosis in the lumbar spine and femoral neck and 20 controls with a normal densitometric diagnosis. Bone mineral density was measured in the patients and controls by dual-energy X-ray absorptiometry. Eighty-two osseointegrated dental implants were placed in the mandible, 39 of them in the osteoporosis group and 43 in the control group. Mandibular bone quality was evaluated by classifying mandibular inferior cortical and trabecular bone on panoramic radiographs and by histomorphometric analysis of a mandibular bone biopsy. Osseointegration was analyzed after 9 months. Results: No significant difference was observed between patients with osteoporosis and controls when comparing individuals with a normal cortex and those with a severely or moderately eroded cortex determined on panoramic radiographs, although patients with MEC/SEC had lower femoral neck BMD than those with NC (0.688 ± 0.17 vs. 0.814 ± 0.144 g/cm 2 , P<0.012). Histomorphometric analysis also revealed no difference in the parameters of bone formation or resorption between the two groups. Implant failure was observed in only one case. Conclusion: We conclude that there is an association between low femoral neck BMD and poor mandibular bone quality as assessed by panoramic radiography. The loss of one implant (1.2%) is compatible with the literature and cannot be attributed to systemic osteoporosis.

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“…26 Conditions that affect bone density can influence osseointegration. Bone-implant contact was reduced by 50% in one study involving implants in osteoporotic rat models, 27 while in humans implant failure appears to parallel decreased bone density. 28,29 Regular oral bisphosphonates were used by 67.8% of patients with osteoporosis/osteopaenia within the study population.…”

Section: Musculoskeletal Related Diseasementioning

confidence: 99%

Analysis of commonly reported medical conditions amongst patients receiving dental implant therapy in private practice

Austin

Bailey

Chandu

et al. 2015

Australian Dental Journal

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Background: The population seeking implants in private practice is a demographically and medically unique group. Understanding their medical needs can improve treatment planning and service delivery specifically for this population. Methods: Privately practising dental clinicians from Victoria, Australia, participated in a five-year retrospective study. Data were collected from the medical histories of 4116 patients who met the inclusion criterion of at least one implant placed within the study period of 1 January 2005 to 31 December 2009. Descriptive statistics were used to describe patient demographics and commonly reported medical conditions. Results: The most common age group to receive implant therapy was between 51 and 60 years (30.4% of patients). The patient population reported a broad range of co-morbidities including psychiatric disorders (83 patients), cardiovascular disorders (253 patients), gastrointestinal disorders (224 patients) and respiratory disorders (502 patients). Smoking was less prevalent amongst the study population compared to the general population. Conclusions: The population assessed in this study was a medically diverse group. Clinicians must be familiar with their target demographic and understand how the common co-morbidities amongst this patient group can influence clinical decision making and outcomes.

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Examination of the Bone???Implant Interface in Experimentally Induced Osteoporotic Bone

Cited by 59 publications

References 24 publications

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Comparative study of axial and femoral bone mineral density and parameters of mandibular bone quality in patients receiving dental implants

Analysis of commonly reported medical conditions amongst patients receiving dental implant therapy in private practice

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