The aetiology of idiopathic scoliosis: biomechanical and neuromuscular factors

Veldhuizen, Albert G.; Wever, Dirk Jan; Webb, P. J.

doi:10.1007/s005860000142

Cited by 99 publications

(63 citation statements)

References 74 publications

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“…Among the hypothesis of AIS etiology, abnormalities in the central nervous system have long been thought a key AIS etiology [29,30]. Disturbance of central nervous system may impair somatosensory function and motor adaptation which lead to asymmetry of neuromuscular condition causing AIS [30,31]. Correspondingly, functional studies in AIS subjects have shown abnormalities in the postural balance and somatosensory function [32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population

et al. 2012

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Purpose To investigate whether rs11190870 near LBX1 correlates with the susceptibility or curve progression of adolescent idiopathic scoliosis (AIS) in a Han Chinese population. Methods A total of 949 AIS patients and 976 age-matched healthy controls were recruited. All the subjects were genotyped using the PCR-based invader assay. Case-control study and case-only study were performed to define the contribution of rs11190870 to predisposition and curve severity of AIS. Additionally, we further conducted a metaanalysis of the study findings together with those of previously reported studies. Results A significant association of rs11190870 with AIS was observed in the Han Chinese population (P = 1.8 9 10 -9 ; odd ratio = 1.51; 95 % confidence interval = 1.33-1.71), and AIS patients with TT genotype had a larger Cobb angle than those with TC or CC genotype (P = 0.005). The meta-analysis confirmed that the positive association of this SNP with AIS in the East Asian population. Conclusions The SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of AIS.

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Section: Discussionmentioning

confidence: 99%

Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population

et al. 2012

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“…Posture is defined as the alignment or orientation of body segments while maintaining an upright position [1]. Posture asymmetries are associated with the risk of progression in IS [2][3][4], can affect functional activities [5,6] and limit participation in active life [7]. The Cobb Angle remains the gold standard to monitor change in scoliosis over time and is calculated from radiographs [8].…”

Section: Introductionmentioning

confidence: 99%

Reliability of a quantitative clinical posture assessment tool among persons with idiopathic scoliosis

et al. 2012

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“…Posture asymmetries are frequently observed among persons with idiopathic scoliosis (IS) [31,46], are associated with muscle imbalance [19,21,35,38,41] and can play an important role in scoliosis progression [4,17,35,41,43]. This progression is attributable to biomechanical factors such as modified trunk alignment and body weight influences which create modifications in muscular moments acting on the spine especially during growth spurt [5,17,35,43].…”

Section: Introductionmentioning

confidence: 99%

“…This progression is attributable to biomechanical factors such as modified trunk alignment and body weight influences which create modifications in muscular moments acting on the spine especially during growth spurt [5,17,35,43]. To restore good posture and to prevent scoliosis progression, physiotherapists work on muscle balance.…”

Section: Introductionmentioning

confidence: 99%

Differences in Standing and Sitting Postures of Youth with Idiopathic Scoliosis from Quantitative Analysis of Digital Photographs

Fortin

Feldman

Cheriet

2013

Physical & Occupational Therapy In Pediatrics

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The objective of this study was to explore whether differences in standing and sitting postures of youth with idiopathic scoliosis could be detected from quantitative analysis of digital photographs. Standing and sitting postures of 50 participants aged 10–20-years-old with idiopathic scoliosis (Cobb angle: 15° to 60°) were assessed from digital photographs using a posture evaluation software program. Based on the XY coordinates of markers, 13 angular and linear posture indices were calculated in both positions. Paired t-tests were used to compare values of standing and sitting posture indices. Significant differences between standing and sitting positions (p < 0.05) were found for head protraction, shoulder elevation, scapula asymmetry, trunk list, scoliosis angle, waist angles, and frontal and sagittal plane pelvic tilt. Quantitative analysis of digital photographs is a clinically feasible method to measure standing and sitting postures among youth with scoliosis and to assist in decisions on therapeutic interventions.CIHR / IRS

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The aetiology of idiopathic scoliosis: biomechanical and neuromuscular factors

Abstract: The aetiology of idiopathic scoliosis: biomechanical and neuromuscular factors small curve develops due to a small defect in the neuromuscular control system and a second stage during adolescent growth in which the scoliotic curve is exacerbated by biomechanical factors.

Cited by 99 publications

References 74 publications

Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population

Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population

Reliability of a quantitative clinical posture assessment tool among persons with idiopathic scoliosis

Differences in Standing and Sitting Postures of Youth with Idiopathic Scoliosis from Quantitative Analysis of Digital Photographs

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