The adverse effect of treatment prolongation in cervical carcinoma

Petereit, Daniel G.; Sarkaria, Jann N.; Chappell, Richard J.; Fowler, J. F.; Hartmann, Trudy J.; Kinsella, Timothy J.; Stitt, Judith A.; Thomadsen, Bruce R.; Buchler, Dolores A.

doi:10.1016/0360-3016(94)00635-x

Cited by 294 publications

(151 citation statements)

References 18 publications

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“…It is assumed that the total time of radiotherapy in cervical cancer patients should not exceed 8 weeks. [29][30][31] Prolongation of the total treatment time over 55-60 days causes a decrease of the local cure and distant survivals by 1% for each day over 55-60 days. 31 In the groups of patients who underwent radiochemotherapy the treatment time ranges from 35 to 92 days (average time 51-52 days).…”

Section: Discussion Of Resultsmentioning

confidence: 99%

Tolerance of combined radiochemotherapy in cervical cancer patients

Izmajłowicz¹,

Rusiecka²,

Sztuder³

et al. 2017

Adv Clin Exp Med

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Background. Radiochemotherapy in cervical cancer was implemented to clinical practice based on 5 randomized clinical trials, published at the end of the 20 th century, which showed improvement in the total and symptomless survivals by about 10-18%. The increase of therapeutic index of such treatment can take place only when the efficiency of the treatment outweighs the increase of its toxicity. Thus, it is necessary to monitor treatment reaction during radiochemotherapy.

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Section: Discussion Of Resultsmentioning

confidence: 99%

Tolerance of combined radiochemotherapy in cervical cancer patients

Izmajłowicz¹,

Rusiecka²,

Sztuder³

et al. 2017

Adv Clin Exp Med

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“…Studies of the increase in tumor control dose with increasing treatment time suggest that after a variable lag period, surviving tumor clonogens regenerate rapidly during fractionated radiation therapy to the extent that each additional day of treatment requires *0.6 Gy, on average, to offset clonogenic cell regeneration, again suggesting a clonogenic cell doubling time of 3.5-5 days [5]. Many trials have conclusively proven overall treatment time to be a major determinant in the outcome in cervix cancer [6][7][8][9][10][11]. The usual recommendation is to complete treatment by 8 weeks (56 days) [12].…”

Section: Discussionmentioning

confidence: 99%

“…The usual recommendation is to complete treatment by 8 weeks (56 days) [12]. Petereit et al [8] have shown that the 5-year survival and pelvic control rates differed significantly with treatment times of B55 days versus C55 days.…”

Section: Discussionmentioning

confidence: 99%

Pure Accelerated Radiation Versus Concomitant Chemoradiation in Selected Cases of Locally Advanced Carcinoma Cervix: A Prospective Study

Roy

Choudhury

Pal

et al. 2012

J Obstet Gynecol India

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Objective This non-randomized study was conducted to assess and compare the response and safety of true accelerated radiation alone to concomitant chemoradiation in locally advanced squamous cell carcinoma of the uterine cervix. Methods Sixty patients with locally advanced squamous cell carcinoma of the uterine cervix, FIGO Stages (2009) IB2-IIIB were non-randomized to receive six fractions per week of external beam radiation (EBRT) (will be henceforth referred to as Arm A or Study arm or pure accelerated radiation arm) and five fractions per week of EBRT and chemotherapy with inj cisplatin 40 mg/m 2 i.v. every

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“…The American Brachytherapy Society recommends keeping the total treatment duration to less than 8 weeks, because prolongation of total treatment duration can adversely affect local control and [20][21][22][23][24] survival. In this present study, the duration of treatment is almost same (58 days vs 57 days) and did not influence significantly on local control.…”

Section: Overall Treatment Timementioning

confidence: 99%