The advanced glycation end-product Nɛ-(carboxymethyl)lysine level is elevated in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Kaufmann, E.; Boehm, B.O.; Süßmuth, Sigurd D.; Kientsch-Engel, Rosemarie; Sperfeld, Anne D.; Ludolph, Albert C.; Tumani, Hayrettin

doi:10.1016/j.neulet.2004.08.071

Cited by 43 publications

(27 citation statements)

References 14 publications

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“…Several recent clinical studies support an oxidative stress hypothesis as a number of biomarkers for oxidative stress have been found abnormal in ALS [6][7][8][9][10][11]. In particular, Bogdanov et al.…”

Section: Introductionmentioning

confidence: 92%

Oxidative stress biomarkers in sporadic ALS

Mitsumoto

Santella

Liu

et al. 2008

Amyotrophic Lateral Sclerosis

145

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Objective-To investigate oxidative stress biomarkers in a cross-sectional pilot study of 50 participants with sporadic ALS (sALS) compared to 46 control subjects.Methods-We measured urinary 8-oxodeoxyguanosine (8-oxodG), urinary 15-F 2t -isoprostane (IsoP), and plasma protein carbonyl by ELISA methods. We also determined if ELISA measurement of 8-oxodG could be validated against measures from high pressure liquid chromatography coupled with electrochemical detection, the current standard method.Results-8-oxodG and IsoP levels adjusted for creatinine were significantly elevated in sALS participants. These differences persisted after age and gender were controlled in regression analyses. These markers are highly and positively correlated with each other. 8-oxodG measured by the two techniques from the same urine sample were positively correlated (P < .0001). Protein carbonyl was not different between sALS participants and controls.Conclusion-Using ELISA we confirmed that certain oxidative stress biomarkers were elevated in sALS participants. ELISA may be reliable and thus useful in epidemiology studies requiring

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Section: Introductionmentioning

confidence: 92%

Oxidative stress biomarkers in sporadic ALS

Mitsumoto

Santella

Liu

et al. 2008

Amyotrophic Lateral Sclerosis

145

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“…Normal aging human brain was shown to accumulate AGEs within neurons and glial cells [10,11] as well as in senile plaques [12]. Beside this "physiological" occurrence of AGEs, pathological accumulations of glycated proteins were found in neurodegenerative diseases such as Alzheimer's (AD) [13], Parkinson's [14], amyotrophic lateral sclerosis (ALS) [15,16], vascular dementia (VD) [17], CreutzfeldJakob (CJD) [18], Pick', and Lewy body diseases [7].…”

Section: Introductionmentioning

confidence: 99%

Characterization of the glycated human cerebrospinal fluid proteome

Ramírez-Boo¹,

Priego-Capote²,

Hainard³

et al. 2012

Journal of Proteomics

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“…These results suggest that glycation is responsible for the oxidative stress, which culminates in ALS. Recently, it has been established that CML concentration is significantly increased in serum and cereberospinal fluid of ALS patient, which may represent diagnostic tool [71]. These data suggest that glycation is involved in ALS.…”

Section: Glycation In Amyotrophic Lateral Sclerosismentioning

confidence: 95%

The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach

Salahuddin

Rabbani

Khan

2014

Cellular and Molecular Biology Letters

148

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of advanced glycation end products; ROS -reactive oxygen species; SNCA -synuclein alpha; sRAGE -soluble receptor of advanced glycation end products; TTR -transthyretin; TKtransketolase; TNF -tumor necrosis factor-α; TPP -thiamine pyrophosphate Review THE ROLE OF ADVANCED GLYCATION END PRODUCTS IN VARIOUS TYPES OF NEURODEGENERATIVE DISEASE:A THERAPEUTIC APPROACH Abstract: Protein glycation is initiated by a nucleophilic addition reaction between the free amino group from a protein, lipid or nucleic acid and the carbonyl group of a reducing sugar. This reaction forms a reversible Schiff base, which rearranges over a period of days to produce ketoamine or Amadori products. The Amadori products undergo dehydration and rearrangements and develop a cross-link between adjacent proteins, giving rise to protein aggregation or advanced glycation end products (AGEs). A number of studies Unauthenticated Download Date | 5/11/18 1:17 PM

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The advanced glycation end-product Nɛ-(carboxymethyl)lysine level is elevated in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Cited by 43 publications

References 14 publications

Oxidative stress biomarkers in sporadic ALS

Oxidative stress biomarkers in sporadic ALS

Characterization of the glycated human cerebrospinal fluid proteome

The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach

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