The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

Vieira, Helena L.A.; Belzacq, Anne Sophie; Haouzi, D.; Bernassola, Francesca; Cohen, Isabel; Jacotot, Étienne; Ferri, Karine F.; Hamel, Chahrazed El; Bartle, Laura M.; Melino, Gerry; Brenner, Catherine; Goldmacher, Victor S.; Kroemer, Guido

doi:10.1038/sj.onc.1204575

Cited by 232 publications

(149 citation statements)

References 69 publications

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“…Notably, mitochondrial membrane polyunsaturated fatty acids are especially prone to ROS-mediated damage, and therefore are highly susceptible to peroxidation (Esterbauer et al 1991). Among the reactive aldehydes stemming from lipid peroxidation, 4-hydroxy-2-nonenal (HNE) has been shown to interfere with mitochondrial function (Chen et al 2001) and to promote mPTP opening (Vieira et al 2001). ROS can also elicit RNS production (Zhang, Li, Prabhakaran, Borowitz, and Isom 2006), via up-regulation of the inducible isoform of nitric oxide synthase (iNOS) (Zhen et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

Marzetti

Wohlgemuth

Lees

et al. 2008

Mechanisms of Ageing and Development

151

149

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Mitochondria-mediated apoptosis represents a central process driving age-related muscle loss. However, the temporal relation between mitochondrial apoptotic signaling and sarcopenia as well as the regulation of release of pro-apoptotic factors from the mitochondria has not been elucidated. In this study, we investigated mitochondrial apoptotic signaling in skeletal muscle of rats across a wide age range. We also investigated whether mitochondrial-driven apoptosis was accompanied by changes in the expression of Bcl-2 proteins and components of the mitochondrial permeability transition pore (mPTP). Analyses were performed on gastrocnemius muscle of 8-, 18-, 29-and 37-month-old male Fischer 344 ×Brown Norway rats (9 per group). Muscle weight declined progressively with advancing age, concomitant with increased apoptotic DNA fragmentation. Cytosolic and nuclear levels of apoptosis inducing factor (AIF) and endonuclease G (EndoG) increased in old and senescent animals. In contrast, cytosolic levels of cytochrome c were unchanged with age. Mitochondrial Bcl-2, Bax and Bid increased dramatically in 37-month-old rats, with no changes in the Bax/Bcl-2 ratio in any of the age groups. Finally, expression of cyclophilin D was enhanced at very old age. Our findings indicate that the mitochondrial caspase-independent apoptotic pathway may play a more prominent role in skeletal muscle loss than caspase-mediated apoptosis.

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Section: Introductionmentioning

confidence: 99%

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

Marzetti

Wohlgemuth

Lees

et al. 2008

Mechanisms of Ageing and Development

151

149

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“…NO itself generally inhibits MPT due to the direct inhibition of respiration preventing calcium accumulation, but very high concentrations can promote MPT probably due to formation of NO 2 /N 2 O 3 (47). RNS may directly oxidise thiols of the adenine nucleotide translocator, a key component of the MPT pore (48).…”

Section: No Actions On Mitochondriamentioning

confidence: 99%

Nitric Oxide, Mitochondria, and Cell Death

Brown¹,

Borutaitė²

2001

IUBMB Life

158

104

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“…ROS may promote MPT by causing oxidation of thiol groups on the adenine nucleotide translocator, which is believed to form part of the MPT pore. 5 Cytochrome c release may also occur via MPT-independent mechanisms and may involve an oligomeric form of Bax 6 ( Figure 3 ). Cytochrome c in the cytoplasm triggers the activation of caspase-9, which triggers the caspase cascade and ultimately leads to apoptosis.…”

Section: Consequences Of Reactive Oxygen and Reactive Nitrogen Speciesmentioning

confidence: 99%

Cell-Permeable, Mitochondrial-Targeted, Peptide Antioxidants

Szeto¹

2008

Drug Addiction

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The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

Cited by 232 publications

References 69 publications

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

Nitric Oxide, Mitochondria, and Cell Death

Cell-Permeable, Mitochondrial-Targeted, Peptide Antioxidants

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