The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double‐blind, randomized trial

Abstract

Objective: To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile. Methods: Women who had excess weight or obesity were recruited to a randomized, double-blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 3 10 10 colony-forming units/day) (n 5 21) or placebo (n 5 22) for 8 weeks. Both groups received a dietary prescription. Body composition was assessed by anthropometry and dualenergy X-ray absorptiometry. The lipid profile, lipid accumulation product, plasma fatty acids, lipopolysaccharide, interleukin-6, interleukin-10, tumor necrosis factor-a, adiponectin, and the antioxidant enzymes activities were analyzed. Results: In comparison with the dietary intervention group, the dietary intervention 1 probiotic mix group showed a greater reduction in the waist circumference (23.40% vs. 25.48%, P 5 0.03), waist-height ratio (23.27% vs. 25.00%, P 5 0.02), conicity index (22.43% vs. 24.09% P 5 0.03), and plasma polyunsaturated fatty acids (5.65% vs. 218.63%, P 5 0.04) and an increase in the activity of glutathione peroxidase (216.67% vs. 15.62%, P < 0.01). Conclusions: Supplementation of a probiotic mix reduced abdominal adiposity and increased antioxidant enzyme activity in a more effective way than an isolated dietary intervention.

Probiotic Foods and Supplements Interventions for Metabolic Syndromes: A Systematic Review and Meta-Analysis of Recent Clinical Trials

“…In addition, there were no significant differences observed in the TC level in the other 2 studies [42,55]. In the 7 studies that evaluated the changes of the triglycerides level, none of them reported significant differences [42,43,48,50,55,56,64]. In order to perform calculation, the researchers standardized the unit-of-measurement to conduct the metaanalysis, lipid levels in mmol/L were converted to mg/dL, and the conversion factor was 1 mmol/L = 38.7 mg/dL for cholesterol and 1 mmol/L = 88.5 mg/dL for triglycerides.…”

“…Among reviewed studies, 2 studies suggested that there were significant differences in reduction of BFM, BFP, or both [51,61], and the other 5 studies did not find significant differences in changes of BFM or BFP [42,50,[55][56][57]. In the 7 reviewed studies (569 participants), the results suggested that there was no significant difference between the intervention groups and the control groups for BFM (p = 0.07, Fig.…”

“…15). HbA1c was only evaluated in 3 studies [47,56,66]. Since there were no original data in the report of Chung et al [47]; thus, the meta-analysis was performed based on the remaining 2 studies (199 participants) [56,66].…”

Gut microbiota and obesity: An opportunity to alter obesity through faecal microbiota transplant (FMT)

“…In conjunction with Lactococcus and Bifidobacterium, supplementation resulted in decreased adiposity and increased antioxidant in humans…”

Obesity and microbiota: an example of an intricate relationship

“…In this context, a group of women with excess body weight or obese phenotype (25< BMI <40) were enrolled for a randomized, double-blind trial to receive a probiotic mix based on L. acidophilus and L. casei , Lactococcus lactis , B. bifidum , and Bifidobacterium lactis for 8 weeks. Supplementation with a probiotic mix reduced abdominal fat and increased antioxidant enzyme activity as compared to dietary intervention alone [146]. …”