Obesity and microbiota: an example of an intricate relationship

Duranti, Sabrina; Ferrario, Chiara; Sinderen, Douwe van; Ventura, Marco; Turroni, Francesca

doi:10.1186/s12263-017-0566-2

Cited by 95 publications

(76 citation statements)

References 175 publications

(224 reference statements)

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“…Liver disorder disease is a complicated metabolic disease and commonly shows a close relationship with obesity as well as the related gut microbiota changes in obesity (Duranti et al, 2017). In gut microbiota transplantation studies, germ-free C57BL/6J mice receiving intestinal bacteria from HFD-fed mice with high blood glucose were prone to develop liver steatosis and insulin resistance compared with counterparts that were transplanted with bacteria from healthy mice (Aron-Wisnewsky et al, 2013).…”

Section: The Causative Role Of Akkermansia Muciniphila In Liver Disormentioning

confidence: 99%

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

et al. 2020

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Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a worldwide epidemic and are intimately linked to diet. The gut microbiota interaction has been pointed to as a hot topic of research in the treatment of obesity and related metabolic diseases by influencing energy metabolism and the immune system. In terms of the novel beneficial microbes identified, Akkermansia muciniphila (A. muciniphila) colonizes the mucosa layer of the gut and modulates basal metabolism. A. muciniphila is consistently correlated with obesity. The causal beneficial impact of A. muciniphila treatment on obesity is coming to light, having been proved by a variety of animal models and human studies. A. muciniphila has been characterized as a beneficial player in body metabolism and has great prospects for treatments of the metabolic disorders associated with obesity, as well as being considered for next-generation therapeutic agents. This paper aimed to investigate the basic mechanism underlying the relation of A. muciniphila to obesity and its host interactions, as identified in recent discoveries, facilitating the establishment of the causal relationship in A. muciniphila-associated therapeutic supplement in humans.

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Section: The Causative Role Of Akkermansia Muciniphila In Liver Disormentioning

confidence: 99%

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

et al. 2020

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“…В настоящее время интерес сосредоточен на установлении роли микробиоты в развитии некоторых заболеваний человека, в том числе ожирения, что отразилось на всплеске публикаций по микробиоте за последние 5 лет. Так, недавние исследования идентифицировали микробиоту кишечника как фактор, влияющий на метаболизм организма через энергетический баланс [7]. Получены данные о том, что микробиота, присутствующая в желудочно-кишечном тракте, является детерминантой развития не только ожирения, но и его метаболического профиля [8].…”

Section: Abstract: Intestinal Microbiota Obesity Metabolically Neutunclassified

“…описал более низкую долю Bacteroidetes и более высокую долю Aktinobacteria у людей с ожирением, чем у худых, без существенных различий в Firmicutes [24]. Имеются публикации, которые предполагают корреляцию между ИМТ и наличием специфических кишечных микроорганизмов [7]. В подтверждение этого недавнее клиническое исследование с участием 263 человек (из них 134 с ожирением, 38 с избыточным весом, 76 человек с нормальной массой тела и 15 с анорексией) подчеркнуло важность конкретных микробов, связанных с ожирением, таких как Bacteroidetes, Firmicutes, M. Methanobrevibacter Smithii, E. coli и различных видов Lactobacillus.…”

Section: Abstract: Intestinal Microbiota Obesity Metabolically Neutunclassified

“…Пребиотики -это пищевые компоненты, стимулирующие рост и/или метаболизм полезных бактерий [7]. Пребиотики представлены углеводами (инулин, лактулоза, галактоолигосахариды), которые недоступны для ферментов, продуцируемых человеческим организмом.…”

Section: модуляция кишечной микробиоты -новая терапевтическая мишеньunclassified

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The role of gut microbiota in the development of obesity and its metabolic profile (Part II)

Volkova¹,

Ganenko²,

Головин³

2019

Medical news of the North Caucasus

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АМФК-аденозинмонофосфаткиназа ИМТ-индекс массы тела КЖК-короткоцепочечные желчные кислоты ЛПС-липополисахарид, МНО-метаболически нейтральное ожирение CB1-каннабиноидные рецепторы 1 CB2-каннабиноидные рецепторы 2 СД-сахарный диабет eCB-эндоканнабиноиды GLP-1-глюкагоноподобный пептид-1

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“…Estes componentes possuem etiologia multifatorial, que envolvem fatores genéticos e ambientais diversos (ALBERTI; ZIMMET; SHAW, 2006;ORG et al, 2017;PHISALPRAPA el al., 2017). Rev Estudos recentes em modelos animais e em h umanos têm mostrado que a alteração da microbiota intesti nal pode ser um dos fatores predisponentes para o aparecimento dos cofatores da SM, especialmente a obesidade (DAHIYA et al, 2017;DURANTI et al, 2017;LAM et al, 2017;LIU et al, 2017). Esta relação pode estar associada a diversos fatores, especialmente pela infl uência que a microbiota exerce sobre o sistema nervoso central, controlando a ingestão energéti ca, e sobre o sistema endócrino, regulando a resposta a diversos hormônios.…”

Section: Introductionunclassified

Tempo de trânsito intestinal de indivíduos portadores de Síndrome Metabólica pela Escala de Bristol

Santos¹,

Lemaire²,

Coutinho-Lima³

2017

cmbio

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ResumoIntrodução: a síndrome Metabólica (SM) é um transtorno de origem multifatorial que envolve a elevação da circunferência da cintura, da glicemia, da pressão arterial e dos triglicerídeos e redução do HDL-colesterol. Na etiopatogenia deste transtorno, diversos fatores genéticos e ambientais estão envolvidos, dentre eles, a alteração da microbiota intestinal pode ser um dos agentes causais deste distúrbio. Devido aos elevados custos para analisar este ecossistema, e à sua impossibilidade na prática clínica, ferramentas podem ser utilizadas com a intenção de monitorar o funcionamento intestinal, a exemplo da Escala de Bristol. Metodologia: foram avaliados indivíduos adultos e idosos com Síndrome Metabólica atendidos entre fevereiro de 2015 e maio de 2017. A síndrome metabólica foi definida de acordo com o preconizado pela Federação Internacional de Diabetes. Foi realizada anamnese com informações a respeito da consistência das fezes e coleta de medidas clínicas e antropométricas. Foi realizada análise estatística descritiva. Resultados: foram incluídos neste estudo 186 pacientes, com predominância do sexo feminino (83,9%) e indivíduos adultos (55,1%). Dentre os critérios da SM, o mais presente foi a pressão arterial elevada (95,1%), e a maior parte dos indivíduos apresentaram ritmo intestinal normal pela Escala de Bristol (54,8%). Em relação à idade entre os grupos, o que apresentou ritmo lento, teve maior média de idade (69 anos) em relação aos grupos com ritmo normal e ritmo rápido (57 e 54 anos, respectivamente). Por sua vez, indivíduos com ritmo intestinal rápido, apresentaram maiores médias de índice de massa corporal. Conclusão: indivíduos com Síndrome Metabólica parecem possuir tempo de trânsito intestinal adequado segundo a Escala de Bristol. Palavras-chave: Síndrome Metabólica. Fezes. Motilidade Gastrointestinal AbstractIntroduction: metabolic syndrome (MS) is a multifactorial disorder that involves elevation of waist circumference, blood glucose, blood pressure and triglycerides, and reduction of HDL-cholesterol. In the etiopathogenesis of this disorder, intestinal health plays an important role, especially in the composition of the microbiota. Due to the high costs to analyze this ecosystem, and the impossibility in clinical practice, other tools can be used with the intention of monitoring the state of health of the microbiota such as the Bristol Scale. Metodology: adult and elderly individuals attended at the Núcleo de Pesquisa e Extensão em Genômica Nutricional e Disfunções Metabólicas of Universidade do Estado da Bahia between February 2015 and May 2017 were evaluated. Anamnesis was performed with information about the consistency of feces and Collection of clinical and anthropometric measurements. The metabolic syndrome was defined according to the International Diabetes Federation. Data were analyzed descriptively. Results: a total of 186 patients were analyzed during the study period, with a predominance of females (83.9%) and adults (55.1%). Among the criteria of MS, the most present was high...

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Obesity and microbiota: an example of an intricate relationship

Cited by 95 publications

References 175 publications

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

The role of gut microbiota in the development of obesity and its metabolic profile (Part II)

Tempo de trânsito intestinal de indivíduos portadores de Síndrome Metabólica pela Escala de Bristol

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