The addition of metformin during ovulation induction with letrozole does not affect pregnancy outcome in infertile women with polycystic ovary syndrome

Hurley, Emily G.; Adams, S.R.; Kalakota, N.; Rios, J. M. Sroga; Thomas, Michael A.

doi:10.1016/j.fertnstert.2017.07.740

Cited by 2 publications

(2 citation statements)

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Section: Discussionsupporting

confidence: 92%

“…Hurley et al 14 found that a total of 268 OI/IUI cycles have been evaluated, with 159 receiving LE-M and 109 receiving LE, which agrees with our results. When the two groups were compared, there were no significant differences in age, AMH, or BMI 14 . Also, Sohrabvand et al, 15 found that there were no significant statistical differences between Group A (letrozole) and Group B (letrozole metformin) in terms of the average demographic factors such as age, BMI, infertility duration, and regular menstruation following metformin 15 .…”

Section: Discussionsupporting

confidence: 92%

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Comparative study between the effect of letrozole versus letrozole with Metformin in treatment of anovulation in overweight women.

Rohaim

Ahmed²,

Galal³

2022

Al-Azhar International Medical Journal

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Background: Ovulation disorders account for around 30% of infertility and are frequently accompanied by irregular menstrual (oligomenorrhoea) or an absence of periods (amenorrhea). Several therapies are easy and efficient, so couples might only require limited contact with doctors. This makes it simpler for a couple to retain a private love connection than in stressful situations. Aim of the work:To assess the impact of letrozole with letrozole plus metformin as an ovulation inducing agent in anovulatory overweight women.Patients and methods: Prospective study was performed on total 100 anovulatory overweight women attending infertility outpatient Clinic in Al-Hussein University Hospitals and Dar Ismail Hospital for Obstetrics and gynecology, Alexandria, Egypt, from 1st March to 31st December 2019.Results: There was an insignificant rise in the cumulative pregnancy rate between the metformin-letrozole and the letrozole groups. In the metformin-letrozole group, 42% of the patents got pregnant, compared with 36% of the patients in the letrozole group. There were no significant differences between the letrozole and the metformin-letrozole groups regarding ovulation rate, number of patients has growing follicle, number of growing follicles (follicles ≥ 18) at day 12, number of ruptured follicles after 48 hours of injection of HCG, serum E2, Parity, clinical presentation, Period of infertility, FSH, LH. There has been a significant rise in group B (8.77) compared to group A (8.23) as regards endometrial thickness. Conclusion: : Metformin added to letrozole does not improve the outcome of an overweight ovulated woman except that it improves endometrial thickness only.

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Section: Discussionsupporting

confidence: 92%