The addition of metamizole to morphine and paracetamol improves early postoperative analgesia and patient satisfaction after lumbar disc surgery

Abstract

Addition of metamizole to paracetamol along with iv morphine PCA offers an advantage over single iv morphine PCA and paracetamol, with respect to early postoperative pain treatment and patient satisfaction.

Comparison of the postoperative analgesic effects of paracetamol–codeine phosphate and naproxen sodium–codeine phosphate for lumbar disk surgery

“…However, the efficacy of paracetamol in postoperative reduction of opioid consumption after major surgery remains controversial. In a study by Tunali et al [6], oral administration of 1 g paracetamol every 6 hours for 24 hours following lumbar disk surgery was not effective at reducing pain scores or morphine consumption compared with placebo; similar results were reported by Uzun et al [14]. A paracetamoleopioid combination is recommended for pain not controlled by paracetamol alone.…”

“…The paracetamol–codeine combination was superior to naproxen sodium–codeine with regard to reducing tramadol consumption. Preemptive NSAIDs and paracetamol have been widely used as multimodal analgesia to treat postoperative pain [14,15].…”

Efficacy of Intravenous Paracetamol and Dexketoprofen on Postoperative Pain and Morphine Consumption After a Lumbar Disk Surgery

“…The supplemental analgesic effect of paracetamol has been studied after lumbar disk surgery. 4,7,[12][13][14] Hernandez-Palazon et al 4 investigated analgesic effect of 2-g IV paracetamol every 6 hours for 3 days after a spinal fusion surgery and they showed that pain scores and cumulative morphine consumption were lower in the paracetamol group. In this study, we used 1-g IV paracetamol at every 6 hours for 24 hours and we could not show any reduction in pain scores and morphine consumption compared with placebo.…”

“…In the present study, the incidence of postoperative nausea and vomiting in the paracetamol group was similar to that of the study conducted by Cakan et al 12 The incidence of postoperative pruritus and urinary retention in the paracetamol group was similar with the previous studies. 13,14 Yazar et al 9 investigated effects of IV dexketoprofen on postoperative pain and tramadol consumption after a lumber disk surgery. They found that dexketoprofen significantly lowers total tramadol consumption and the incidence of postoperative nausea and vomiting.…”

Neuroanesthesiology Update

“…[49][50][51] To determine whether the nonsteroidal anti-inflammatory drug dexketoprofen was also effective in reducing narcotic requirement, Yazar et al 52 randomized 60 patients undergoing lumbar discectomy to receive either dexketoprofen (n = 30) 50 mg i.v. [49][50][51] To determine whether the nonsteroidal anti-inflammatory drug dexketoprofen was also effective in reducing narcotic requirement, Yazar et al 52 randomized 60 patients undergoing lumbar discectomy to receive either dexketoprofen (n = 30) 50 mg i.v.…”