The added value of [18F]fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy: a retrospective study involving 49 children

Ribeiro, Maria-João; Boddaert, Nathalie; Bellanné‐Chantelot, Christine; Bourgeois, Sandrine; Valayannopoulos, Vassili; Delzescaux, Thierry; Jaubert, Françis; Nihoul‐Feketé, Claire; Brunelle, Françis; Lonlay, Pascale de

doi:10.1007/s00259-007-0498-y

Cited by 66 publications

(56 citation statements)

References 38 publications

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“…In this field, the lack of a prompt availability of 18 F-DOPA may be overcome by using radiolabelled somatostatin analogues. The study confirmed, in a relatively high number of patients, the well-known [9,14] high sensitivity, specificity, positive and negative predictive value (100%) of 18 F-DOPA PET/CT in detecting the focal form of CHI. Furthermore, the high accuracy of 18 F-DOPA PET/CT, confirmed by histopathology in the majority of the cases, was also achieved by combining functional PET information with the anatomical information provided by ceCT.…”

supporting

confidence: 61%

“…This approach may reduce the possibility of treatment-related events as diabetes or exocrine pancreas deficiency [8]. 18 F-DOPA is a precursor of catecholamine and is taken up by the neuroendocrine cells by the pancreatic islet by using the large aminoacid transporter 2 [9]. Pancreatic neuroendocrine cells are able to take up amino acids and to transform them into biogenic amine by means of decarboxylation.…”

mentioning

confidence: 99%

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Could 68Ga-somatostatin analogues be an important alternative to 18F-DOPA PET/CT in pediatrics?

Piccardo

Treglia

2017

Eur J Nucl Med Mol Imaging

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supporting

confidence: 61%

mentioning

confidence: 99%

Could 68Ga-somatostatin analogues be an important alternative to 18F-DOPA PET/CT in pediatrics?

Piccardo

Treglia

2017

Eur J Nucl Med Mol Imaging

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“…Konwencjonalne badania, takie jak ultrasonografia, tomografia komputerowa lub rezonans magnetyczny, nie są w stanie wykryć zmian ogniskowych w trzustce [4][5][6][7][8].Obrazowanie przy pomocy badania PET (ang. Positron Emission Tomography) ze znacznikiem [18F]-L-3,4-dihydroksyfenyloalaniny (18-F-DOPA) zrewolucjonizowało diagnostykę wrodzonego hiperinsulinizmu.…”

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Significance of diagnostic imaging of congenital hyperinsulinism – clinical case of siblings

Buraczewska¹,

Myśliwiec²

2015

Pediatr. Endocrinol.

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Congenital hyperinsulinism is the commonest cause of hypoglycemia in childhood. Focal form of congenital hyperinsulinism is present in half of affected patients requiring surgical management. We present the case of two sisters diagnosed with focal form of congenital hyperinsulinism and the impact of diagnostic process on clinical management and postoperative complications. In Older sister subtotal pancreatectomy was performed causing insulin-dependent diabetes and need for pancreatic enzymes substitution. In second case of younger sister the decision about the surgery was made after 18-F-DOPA PET scan and selective resection of identified focal lesion was applied. In effect there were no complications after surgery and complete recovery was observed. 18-F--DOPA PET imaging allows to differentiate between diffuse and focal form of congenital hyperinsulinism and determines further management. Identification and adequate localization of focal changes allow surgical planning and in effect to perform selective focal surgery that significantly decreases postoperative complications. Pediatr. Endocrinol. 2015.14.3.52.47-50. © Copyright by PTEiDD 2015 Słowa kluczowe 18-F-DOPA PET, wrodzony hiperinsulinizm, postać ogniskowa StreszczenieWrodzony hiperinsulinizm jest najczęstszą przyczyną hipoglikemii wieku rozwojowego. U połowy niemowląt z rozpoznanym wrodzonym hiperinsulinizmem, u któ-rych wymagana jest resekcja trzustki, stwierdza się potencjalnie wyleczalną postać ogniskową. Przedstawiamy przypadek dwóch sióstr, u których zdiagnozowano postać ogniskową wrodzonego hiperinsulinizmu, oraz wpływ wykonanych badań diagnostycznych na zastosowane leczenie i występowanie powikłań pooperacyjnych. U starszej siostry po wykonanej subtotalnej resekcji trzustki rozwinęła się cukrzyca wymagająca insulinoterapii oraz konieczna była substytucja enzymów trzustkowych. U drugiej, młodszej siostry, u któ-rej przed podjęciem decyzji o leczeniu operacyjnym możliwe było wykonanie badania 18-F-DOPA PET, wykonano zabieg izolowanej resekcji uwidocznionego w badaniu ogniska. Dzięki takiemu postępowaniu u tej pacjentki nie obserwowano jakichkolwiek powikłań pooperacyjnych i uzyskano całkowite ustąpienie objawów hipoglikemii. Diagnostyka obrazowa za pomocą 18-F-DOPA PET pozwala na różnicowanie postaci rozlanej i ogniskowej wrodzonego hiperinsulinizmu i warunkuje dalszy sposób leczenia. Identyfikacja i dokładna lokalizacja zmian ogniskowych znajduje zastosowanie w planowaniu przedoperacyjnym, co wiąże się z resekcją ograniczoną do ogniska i w wyniku tego prowadzi do zmniejszenia powikłań pooperacyjnych u leczonych dzieci.

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“…The authors concluded by proposing 18 F-DOPA-PET/CT as the best modality of choice in locating a focal lesion [36] . Riberio et al [40] did a retrospective study in 2007 on forty nine children with CHI who had undergone 18 F-DOPA-PET/CT scanning. They identified abnormal focal pancreatic uptake of 18 F-DOPA in 15 children, where diffuse radio-tracer uptake was observed in the pancreatic area in the other 34 children.…”

mentioning

confidence: 99%

“…In children who underwent both PET and PVS, the results were concordant in 11 out of 12. The authors concluded that PET scan with 18 F-DOPA is an accurate non-invasive technique allowing differential diagnosis between focal and diffuse forms of CHI [40] . Arbizu Lostao et al [41] reported their first patient from Spain in whom the diagnosis of focal CHI was made in a 13 month old child using combined genetic analysis [paternal heterozygous mutation (G111R) in the ABCC8 gene] and 18 F-DOPA-PET/CT imaging (focal uptake in the body of the pancreas) was successfully treated by surgery.…”

mentioning

confidence: 99%

Congenital hyperinsulinism: Role of fluorine-18L-3, 4 hydroxyphenylalanine positron emission tomography scanning

Gopal‐Kothandapani

Hussain

2014

WJR

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Congenital hyperinsulinism (CHI) is a rare but complex heterogeneous disorder caused by unregulated secretion of insulin from the β-cells of the pancreas leading to severe hypoglycaemia and neuroglycopaenia. Swift diagnosis and institution of appropriate management is crucial to prevent or minimise adverse neurodevelopmental outcome in children with CHI. Histologically there are two major subtypes of CHI, diffuse and focal disease and the management approach will significantly differ depending on the type of the lesion. Patients with medically unresponsive diffuse disease require a near total pancreatectomy, which then leads on to the development of iatrogenic diabetes mellitus and pancreatic exocrine insufficiency. However patients with focal disease only require a limited pancreatectomy to remove only the focal lesion thus providing complete cure to the patient. Hence the preoperative differentiation of the histological subtypes of CHI becomes paramount in the management of CHI. Fluorine-18L-3, 4-hydroxyphenylalanine positron emission tomography ( 18 F-DOPA-PET) is now the gold standard for pre-operative differentiation of focal from diffuse disease and localisation of the focal lesion. The aim of this review article is to give a clinical overview of CHI, then review the role of dopamine in β-cell physiology and finally discuss the role of

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The added value of [18F]fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy: a retrospective study involving 49 children

Abstract: These data demonstrate that PET with [(18)F]fluoro-L-DOPA is an accurate non-invasive technique allowing differential diagnosis between focal and diffuse forms of HI.

Cited by 66 publications

References 38 publications

Could 68Ga-somatostatin analogues be an important alternative to 18F-DOPA PET/CT in pediatrics?

Could 68Ga-somatostatin analogues be an important alternative to 18F-DOPA PET/CT in pediatrics?

Significance of diagnostic imaging of congenital hyperinsulinism – clinical case of siblings

Congenital hyperinsulinism: Role of fluorine-18L-3, 4 hydroxyphenylalanine positron emission tomography scanning

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