The acute toxicity of oxamniquine in rats; a sex-dependent hepatotoxicity

Gregory, Malcolm; Monro, A. M.; Quinton, Michael; Woolhouse, N. M.

doi:10.1007/bf01239209

Cited by 7 publications

References 12 publications

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Hepatotoxicity

Hinton

Grasso

Marrs

2009

General, Applied and Systems Toxicology

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The liver has many physiological roles and is a key organ in detoxication. Furthermore, the liver is affected by a very large number of xenobiotics. The liver also has an immense capacity for self‐repair, so that the many abnormalities of structure or function in the liver reverse rapidly on cessation of xenobiotic exposure. Nevertheless the liver's defences can be overwhelmed. Acute liver failure can be caused by many compounds e.g. paracetamol (acetaminophen), while repeated liver damage, for example from ethanol, may lead to cirrhosis. While primary liver cancer is rare in Western Europe and North America, it is common in other parts of the world such as sub‐Saharan Africa, alcohol and aflatoxins being amongst the aetiological factors. Non‐dose‐dependent adverse effects on the liver are common with many classes of drug and may be sufficiently severe to require cessation of treatment. In the regulatory context it is important to recognize the difference between adaptive and toxic effects.

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Hepatotoxicity

Hinton

Grasso

Marrs

2009

General, Applied and Systems Toxicology

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Unravelling Sex Differences in Drug‐Induced Liver Injury

Tong

Shi

Salminen

et al. 2009

General, Applied and Systems Toxicology

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Liver toxicity accounts for 40% of failed drugs in clinical studies and approximately 21% of drugs that are removed from the market. It is suspected that drug‐induced liver injury (DILI) is more common in females, thus impacting women's health to a higher degree. However, it is unclear how common this potential sex‐based sensitivity may be and the mechanisms underlying the differences. High‐content and high‐throughput molecular technologies such as DNA microarrays have contributed significantly to the understanding of health and disease at the molecular level. In 2001, DNA microarray studies began to emerge to investigate sex‐associated liver gene expression profiles under physiological and pathological conditions. This review is an analysis of clinical reports published to date to determine the weight of evidence in support of sex‐biased sensitivity to DILI. Sex differences related to disease susceptibility/progression and adverse drug events are discussed at the molecular level with emphasis on genomic data in an attempt to place the evidence in a biological context.

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Liver and Pancreas

Greaves¹

2012

Histopathology of Preclinical Toxicity Studies

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The acute toxicity of oxamniquine in rats; a sex-dependent hepatotoxicity

Cited by 7 publications

References 12 publications

Hepatotoxicity

Hepatotoxicity

Unravelling Sex Differences in Drug‐Induced Liver Injury

Liver and Pancreas

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