The acute systemic toxicity of thallium in rats produces oxidative stress: attenuation by metallothionein and Prussian blue

Anaya-Ramos, Laura; Dı́az-Ruiz, Araceli; Rı́os, Camilo; Méndez‐Armenta, Marisela; Montes, Sergio; Aguirre-Vidal, Yoshajandith; García‐Jiménez, Sara; Barón-Flores, Verónica; Monroy-Noyola, Antonio

doi:10.1007/s10534-021-00343-8

Cited by 9 publications

(6 citation statements)

References 51 publications

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“…However, that study contrasts with other results for the effects of Tl exposure on rat kidney. For example, an intraperitoneal dose of 16 mg kg –1 Tl resulted in a significant decrease in renal GSH after 5 days (Anaya‐Ramos et al, 2021). Effects of Tl on GSH have also been observed in rat brain, where an intraperitoneal dose of 32 mg kg –1 resulted in an increase in hypothalamus GSH after 24 hours (Osorio‐Rico et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Effects of Acute and Subchronic Waterborne Thallium Exposure on Ionoregulatory Enzyme Activity and Oxidative Stress in Rainbow Trout (Oncorhynchus mykiss)

Nagel,

Cuss,

Goss

et al. 2023

Enviro Toxic and Chemistry

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The mechanisms of acute (96 h) and sub‐chronic (28‐d) toxicity of the waterborne trace metal thallium (Tl) to rainbow trout (Oncorhynchus mykiss) were investigated. Specifically, effects on branchial and renal ionoregulatory enzymes (sodium/potassium ATPase and proton ATPase) and hepatic oxidative stress endpoints (protein carbonylation, glutathione content and activities of catalase and glutathione peroxidase) were examined. Fish (19‐55 g) were acutely exposed to 0 (control), 0.9 (regulatory limit), 2004 (half the acute median lethal concentration) or 4200 (acute median lethal concentration) µg Tl L‐1 or sub‐chronically exposed to 0, 0.9 or 141 (an elevated environmental concentration) µg Tl L‐1. The only effect following acute exposure was a stimulation of renal H+‐ATPase activity at the highest Tl exposure concentration. Similarly, the only significant effect of sub‐chronic Tl exposure was an inhibition of branchial NKA activity at 141 µg Tl L‐1, an effect that may reflect the interaction of Tl with potassium ion handling. Despite significant literature evidence for effects of Tl on oxidative stress, there were no effects of Tl on any such endpoint in rainbow trout, regardless of exposure duration or exposure concentration. Elevated basal levels of antioxidant defences may explain this finding. These data suggest that ionoregulatory perturbance is a more likely mechanism of Tl toxicity than oxidative stress in rainbow trout, but is an endpoint of relevance only at elevated environmental Tl concentrations.

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Section: Discussionmentioning

confidence: 99%

Effects of Acute and Subchronic Waterborne Thallium Exposure on Ionoregulatory Enzyme Activity and Oxidative Stress in Rainbow Trout (Oncorhynchus mykiss)

Nagel,

Cuss,

Goss

et al. 2023

Enviro Toxic and Chemistry

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“…Tl toxicity is also related to the generation of ROS, which cause tissue damage and dysfunction ( Villaverde et al, 2004 , Galván-Arzate et al, 2005 , Hanzel et al, 2005 , Eskandari et al, 2015 , Kiliç and Kutlu, 2010 , Anaya-Ramos et al, 2021 ). Eskandari et al (2015) demonstrated that Tl + increases ROS production by impairing the electron transfer chain in isolated rat liver mitochondria, activating the cell death signaling pathway.…”

Section: Toxicological Mechanismmentioning

confidence: 99%

“…Prussian blue is orally administered ( Galván-Arzate and Santamaría, 1998 ) and exchanges K for Tl in the gut to increase the fecal excretion of a complex of Tl and Prussian blue ( Rusyniak et al, 2010 ). A recent study demonstrated that MT alone or in combination with Prussian blue plays a cytoprotective role after Tl exposure ( Anaya-Ramos et al, 2021 ). In addition, activated charcoal can be used ( Cvjetko et al, 2010 , Rusyniak et al, 2010 ).…”

Section: Medical Treatment Of Tl Poisoningmentioning

confidence: 99%

Thallium - poisoner’s poison: An overview and review of current knowledge on the toxicological effects and mechanisms

Fujihara,

Nishimoto

2024

Current Research in Toxicology

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“…Along with metallothionein, Tl concentrations declined at most systemic organs, which contributes with relevant antidotal treatment of acute thallotoxicosis. [123] Vaishali et al [124] have reported a study to clarify the possibility of duodenum targeting and desirable release which can bind Tl ions specifically. However, the article has not discussed the adsorption efficiency in vivo.…”

Section: Excretionmentioning

confidence: 99%

“…Along with metallothionein, Tl concentrations declined at most systemic organs, which contributes with relevant antidotal treatment of acute thallotoxicosis [123] . Vaishali et al [124] .…”

Section: Biological Application Of Prussian Blue and Its Analoguementioning

confidence: 99%

Prussian Blue and Its Analogues: From Properties to Biological Applications

Zeng,

Su,

Wang

et al. 2023

ChemistrySelect

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The utilization of metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied because of their unique properties. In recently years, Prussian blue (PB) is widely used in clinical studied due to its biosafety, which has already been approved by USA Food and Drug Administration (FDA). Therefore, it is great urgent to systematically summarize the resent progress to better serve the broad community of researchers. This review focuses on the properties of PB and PB analogues (PBA), and their applications in biological field. A systemic introduction of the properties is presented, including abilities of photothermal, scavenging of reactive oxygen species and adsorption. A variety of biomedical applications, such as tumor therapy, anti‐bacterial infection, biosensor, bioimaging, excretion, ischemic stroke treatment, etc. have been discussed as well. Furthermore, the challenges, key factors, and the prospects in the clinical transformation of PB or PBA are simultaneously discussed. This review will provide reference and guidance for the design and application of PB and PBA in the future.

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The acute systemic toxicity of thallium in rats produces oxidative stress: attenuation by metallothionein and Prussian blue

Cited by 9 publications

References 51 publications

Effects of Acute and Subchronic Waterborne Thallium Exposure on Ionoregulatory Enzyme Activity and Oxidative Stress in Rainbow Trout (Oncorhynchus mykiss)

Effects of Acute and Subchronic Waterborne Thallium Exposure on Ionoregulatory Enzyme Activity and Oxidative Stress in Rainbow Trout (Oncorhynchus mykiss)

Thallium - poisoner’s poison: An overview and review of current knowledge on the toxicological effects and mechanisms

Prussian Blue and Its Analogues: From Properties to Biological Applications

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