The Acute Effects of Increased Intra-abdominal Pressure on Testicular Tissue: An Experimental Study in Pigs

İstanbulluoğlu, Mustafa Okan; Piskin, Mesut; Zor, Murat; Celik, Asuman; Ozgok, Aysegul; Ateş, Mutlu; Üstün, Hüseyin; Özgök, Yaşar

doi:10.1016/j.urology.2010.06.009

Cited by 4 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, no difference was observed in relation to the Johnsen's score 7 , which corroborates to our findings.…”

Section: Discussionsupporting

confidence: 92%

“…It was previously reported that a 20mmHg pneumoperitoneum increased apoptosis of germinal cells in pig testicles 7 and a 10 or 20mmHg pneumoperitoneum resulted in a decreased blood flow with augmented oxidative stress and histologic damage in testicles of a rat model 8 Thus, these studies demonstrated that the testicles can be affected by pneumoperitoneum. On the other hand, surgeons commonly use pneumoperitoneum pressures of up to 15 mmHg in humans, what may corresponds to an 8 mmHg in rats 9 .…”

Section: Introductionmentioning

confidence: 62%

“…There are few experimental studies upon this topic, moreover they investigated the effects of intra-abdominal pressures in pigs 7,8 and rats 7,8 Regarding the hepatic portal blood flow, a pneumoperitoneum of 14 mmHg was sufficient to cause a significant decrease 15 .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pneumoperitoneum induces morphological alterations in the rat testicle

et al. 2013

View full text Add to dashboard Cite

PURPOSE:To investigate the seminiferous tubule histological morphology after an 8 mmHg pneumoperitoneum in the rat model. METHODS:Fourteen rats were divided into two groups: a Sham group submitted to anesthesia and a pneumoperitoneum (Pp) group submitted to abdominal insufflation at 8 mmHg during three hours, followed by desuflation. All rats were killed after six weeks, testicles were collected and evaluated for the tubule diameter, germinative epithelium height and Johnsen´s score. Means were compared by using the Student's-t-test. RESULTS:The seminiferous tubule diameter was diminished by 11.3% in the group submitted to pneumoperitoneum (p<0.05). No significant difference was found among the groups when analyzing the epithelium height and Johnsen´s score. CONCLUSION:In the rat model, the seminiferous tubules present structural alterations when subjected to pneumoperitoneum of 8 mmHg during three hours.

show abstract

“…However, no difference was observed in relation to the Johnsen's score 7 , which corroborates to our findings.…”

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 62%

See 1 more Smart Citation

Pneumoperitoneum induces morphological alterations in the rat testicle

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The Studies used pneumoperitoneum produced from abdominal cavity insufflation using carbon dioxide, however this information was not found in Aydin et al (2014). Procedures were performed on pigs after pre-anesthetic medication with ketamine and xylazine, induction with propofol, and maintenance of inhalation anesthesia with the use of sevoflurane (Istanbulluoglu et al, 2011) in rats after general injectable anesthesia with ketamine hydrochloride and xylazine (Aydin et al, 2014;Imamoglu et al, 2013;İmamoğlu et al, 2006;Rifaioglu et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

“…The testes of the 10mmHg and 20mmHg groups presented higher levels of MDA compared to the control group. Using immunohistochemistry, Istanbulluoglu et al (2011) observed an increase in nitric oxide-producing enzymes (induced and endothelial) in animal testes that underwent 20 mmHg of IAP. The study conducted by Rifaioglu et al (2014) revealed the oxidative and total antioxidant (TOS and TAS) conditions of animals exposed to pneumoperitoneum, where the control group showed the highest TAS and lowest TOS while the pneumoperitoneum group with 15 mmHg showed the lowest TAS and the highest TOS.…”

Section: Resultsmentioning

confidence: 99%

Pneumoperitoneum effect on testicular oxidative stress and histopathology – Systematic review

Almeida

Milech

Brun

et al. 2021

RSD

View full text Add to dashboard Cite

Pneumoperitoneum is characterized by the presence of abdominal cavity gas. Thus, this is used as a tool to create a space in the abdominal cavity for video laparoscopic surgical procedures. However, insufflation of abdominal cavity is capable of causing damage induced by tissue ischemia and reperfusion, which is caused by hypoxia and an imbalance between free radical production and antioxidant defense system capacity. The objective of this study was to bibliographic review the negative effects of exposing healthy animals to different pneumoperitoneum settings by assessing oxidative stress and testicular histopathology, identifying intra-abdominal pressures that did not result in testicular alteration. A systematic search was carried out in three databases using the following terms: pneumoperitoneum AND testi* or gonad. The survey conducted in the databases yielded 2209 scientific articles. After applying inclusion and exclusion criteria, six papers were selected. All the articles selected addressed the effects of pneumoperitoneum on testicular structure and used at least one scoring system to perform histopathological evaluation of the testis. Three studies verified the occurrence of changes in oxidative stress. According to this literature review, pneumoperitoneum used at intra-abdominal pressures equal to, or greater than, 9 mmHg caused testicular histological damage. According to the biomarkers used in studies, pressures greater than 10 mmHg were sufficient to cause testicular oxidative stress.

show abstract