The acute effect of the antioxidant drug “U-74389G” on red blood cells levels during hypoxia reoxygenation injury in rats

Tsompos, Constantinos; Panoulis, Constantinos; Toutouzas, Konstantinos; Zografos, George; Papalois, Αpostolos

doi:10.1016/s2221-6189(14)60068-8

Cited by 7 publications

(9 citation statements)

References 9 publications

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“…These membrane-associated antioxidants are particularly effective in preventing permeability changes in brain microvascular endothelial cell monolayers (2). The same authors of that study found the influence of U-74389G, as depicted in Table 1, on some seric variable levels in related IR injury experiments at the same endpoints with the present experiment after clamp removal in rats (3,4). 3693/12-11-2010 and 14/10-1-2012 decisions.…”

Section: Introductionsupporting

confidence: 73%

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The Effect of the Antioxidant Drug “U-74389G” on Creatine Phosphokinase Levels during Ischemia Reperfusion Injury in Rats

Tsompos¹,

Panoulis²,

Tutouzas³

et al. 2015

Erciyes Med J

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This experimental study examines the effect of the antioxidant drug "U-74389G" on rat model, particularly in an ischemia-reperfusion (IR) protocol. The effects of this molecule were biochemically studied using mean creatinine phosphokinase (CPK) levels in blood. Materials and Methods: Forty rats with a mean weight of 231.875 g were used in the study. CPK levels were measured at 60 min (groups A and C) and at 120 min of reperfusion (groups B and D); A and B were groups without U-74389G administration, but C and D were groups with U-74389G administration. Results: U-74389G administration significantly increased CPK levels by 35.34%+17.20% (p=0.0260). Reperfusion time nonsignificantly increased CPK levels by 13.17%+18.05% (p=0.4134). However, U-74389G administration and reperfusion time together non-significantly increased CPK levels by 18.52%+9.44% (p=0.0770). Conclusion: U-74389G administration significantly increased CPK levels for a short term; however, these levels could not be restored, and the restoration capacity increases along with reperfusion time.

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Section: Introductionsupporting

confidence: 73%

“…The experiment started with animals subjected to pre-narcosis followed by general anesthesia, as described in detail in related references (3,4). Their electrocardiogram, acidometry, and oxygen supply were continuously provided.…”

Section: Introductionmentioning

confidence: 99%

The Effect of the Antioxidant Drug “U-74389G” on Creatine Phosphokinase Levels during Ischemia Reperfusion Injury in Rats

Tsompos¹,

Panoulis²,

Tutouzas³

et al. 2015

Erciyes Med J

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show abstract

“…The effect of the antioxidant drug U-74389G on urea levels during ischemia reperfusion injury in rats N o n -c o m m e r c i a l u s e o n l y [3][4][5][6][7] oxygen supply, electrocardiogram and acidometry. Post-experimental awakening and preservation of animals were not permitted, even if euthanasia was needed.…”

Section: This Basic Experimental Research Was Licensed Bymentioning

confidence: 99%

The effect of the antioxidant drug U-74389G on urea levels during ischemia reperfusion injury in rats

Tsompos

Panoulis

Toutouzas³

et al. 2017

Ital J Med

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This experimental study examined the effect of the antioxidant drug U-74389G, on a rat model and particularly in a renal ischemia-reperfusion protocol. The effects of that molecule were studied biochemically using blood mean urea levels. Forty rats of mean weight 231.875 g were used in the study. Urea levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration significantly decreased the predicted urea levels by 11.35%±2.73% (P=0.0001). Reperfusion time non-significantly increased the predicted urea levels by 2.26%±3.29% (P=0.4103). However, U-74389G administration and reperfusion time together significantly decreased the predicted urea levels by 6.31%±1.70% (P=0.0005). U-74389G administration whether it interacted or not with reperfusion time had significant decreasing effect on the urea serum levels, reflecting a respective renal function augmentation.

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“…7 days pre-experimental normal housing included ad libitum diet in laboratory. Prenarcosis of animals preceded of continuous intra-experimental general anesthesia [3][4][5][6], oxygen supply, electrocardiogram and acidometry. Post-experimental euthanasia did not permitted awakening and preservation of the animals.…”

Section: Animal Preparationmentioning

confidence: 99%

The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats

Tsompos¹,

Panoulis

Toutouzas³

et al. 2016

Acta Medica Bulgarica

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Summary. This experimental study examined the effect of the antioxidant drug U-74389G on a rat model and particularly in a liver ischemia -reperfusion protocol. The effects of that molecule were studied biochemically using blood mean albumin levels. 40 rats of mean weight 231.875 g were used in the study. Albumin levels were measured at 60th min of reperfusion (groups A and C) and at 120th min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration signifi cantly decreased the predicted albumin levels by 3.63% ± 0.87% (p = 0.0001). Reperfusion time non-signifi cantly increased the predicted albumin levels by 0.72% ± 1.04% (p = 0.4103). However, U-74389G administration and reperfusion time together signifi cantly decreased the predicted albumin levels by 2.02% ± 0.54% (p = 0.0005). U-74389G administration whether it interacted or not with reperfusion time has signifi cant decreasing short -term effects on albumin levels. It seems that the antioxidant capacity is associated with albumin catabolism.

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The acute effect of the antioxidant drug “U-74389G” on red blood cells levels during hypoxia reoxygenation injury in rats

Cited by 7 publications

References 9 publications

The Effect of the Antioxidant Drug “U-74389G” on Creatine Phosphokinase Levels during Ischemia Reperfusion Injury in Rats

The Effect of the Antioxidant Drug “U-74389G” on Creatine Phosphokinase Levels during Ischemia Reperfusion Injury in Rats

The effect of the antioxidant drug U-74389G on urea levels during ischemia reperfusion injury in rats

The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats

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