The acupuncture point and its connecting central pathway for producing acupuncture analgesia

Takeshige, Chifuyu; Oka, Kiyoshi; Mizuno, Terumichi; Hisamitsu, Tadashi; Luo, C.P.; Kobori, Masuko; Mera, Hitoshi; Fang, Tian-Quiao

doi:10.1016/0361-9230(93)90039-e

Cited by 99 publications

(62 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All of these areas have been involved in acupuncture analgesia. Using combined lesion techniques and evoked potentials, Takeshige et al (20)(21)(22)(23)(24) reported that the dorsal periaqueductal gray (PAG) arcuate nucleus, lateral and posterior hypothalamus, lateral septum, dorsal hippocampus, habenula-interpeduncular tract, central medial nucleus of the thalamus and anterior hypothalamus are involved in acupuncture analgesia. Studies with mapping of neuronal activity using c-Fos immunohistochemistry in unanesthetized animals have shown that both 2 and 100 Hz EA can up-regulate c-Fos expression in several regions of the brain, including the lateral habenula, PVH, arcuate nucleus, PAG and gigantocellular nucleus (25,26).…”

Section: Specific Effect Of Stimulation At Point 36smentioning

confidence: 99%

c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization

Medeiros

Canteras

Suchecki

et al. 2003

Braz J Med Biol Res

View full text Add to dashboard Cite

In laboratory animals, acupuncture needs to be performed on either anesthetized or, if unanesthetized, restrained subjects. Both procedures up-regulate c-Fos expression in several areas of the central nervous system, representing therefore a major pitfall for the assessment of c-Fos expression induced by electroacupuncture. Thus, in order to reduce the effect of acute restraint we used a protocol of repeated restraint for the assessment of the brain areas activated by electroacupuncture in adult male Wistar rats weighing 180-230 g. Repeated immobilization protocols (6 days, 1 h/day and 13 days, 2 h/ day) were used to reduce the effect of acute immobilization stress on the c-Fos expression induced by electroacupuncture at the Zusanli point (EA36S). Animals submitted to immobilization alone or to electroacupuncture (100 Hz, 2-4 V, faradic wave) in a non-point region were compared to animals submitted to electroacupuncture at EA36S (4 animals/subgroup). c-Fos expression was measured in 41 brain areas by simple counting of cells and the results are reported as number of c-Fos-immunoreactive cells/10,000 µm 2 . The protocols of repeated immobilization significantly reduced the immobilizationinduced c-Fos expression in most of the brain areas analyzed (P < 0.05). Animals of the EA36S groups had significantly higher levels of c-Fos expression in the dorsal raphe nucleus, locus coeruleus, posterior hypothalamus and central medial nucleus of the thalamus. Furthermore, the repeated immobilization protocols intensified the differences between the effects of 36S and non-point stimulation in the dorsal raphe nucleus (P < 0.05). These data suggest that high levels of stress can interact with and mask the evaluation of specific effects of acupuncture in unanesthetized animals.

show abstract

Section: Specific Effect Of Stimulation At Point 36smentioning

confidence: 99%

c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization

Medeiros

Canteras

Suchecki

et al. 2003

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Tan and Horn 25 did not get a satisfactory explanation of 'Qi' flow and balance in accordance to western medicine. While Takeshige et al 26 speculated that acupuncture points stimulation can modify respiration by influencing the respiratory centres in medulla. Jobst et al 27 and Lau & jones 5 have hypothesised that acupuncture stimulates hypothalamus which releases endogenous opiates, thereby reducing dyspnoea.…”

Section: Discussionmentioning

confidence: 99%

The effect of Acu-TENS on FEV1, six minute walk distance and dyspnoea in patients with chronic obstructive pulmonary disease: a randomised trial

Vyas

Shah

Tiwari

et al. 2013

Int J of Biomed & Adv Res

View full text Add to dashboard Cite

“…Há confirmação de que a acupuntura atua pela estimulação neural periférica, gerando mensagens que alcançam o sistema nervoso central, inclusive o LC (TAKESHIGE et al, 1993), modulando os sistemas autonômico, endócrino e neuro-imunitário, por meio da ativação do eixo hipotálamo-hipófise-adrenal, gerando respostas antinociceptivas, anti-inflamatórias e homeostáticas e promovendo o bem-estar e a recuperação da saúde nas afecções dolorosas ou funcionais (BALDRY, 2002;CABIOGLU & ARSLAN, 2008;HALTRECHT 1999;KLEINHENZ, 1995). Entretanto, a escolha dos PCA sobre dermátomos e miótomos relacionados ao sítio do processo inflamatório é essencial para eficácia do método (HALTRECHT 1999;JOAQUIM, 2003;SCOGNAMILLO-SZABÓ & BECHARA, 2001), pois o estímulo da acupuntura é transmitido a partir do PCA para a medula espinal pelos nervos periféricos aferentes, semelhantemente ao que ocorre com o estímulo da dor, sugerindo-se que a acupuntura induza analgesia segmentar, bem como module a dor por inibição descendente, o que ocorre pela mediação de diferentes porções do sistema nervoso central, dentre as quais o LC.…”

Section: A Investigação Científica Na Acupunturaunclassified

O uso da acupuntura no auxílio à terapia da doença idiopática do trato urinário inferior dos felinos

Giovaninni

Piai

2010

Cienc. Rural

View full text Add to dashboard Cite

show abstract

The acupuncture point and its connecting central pathway for producing acupuncture analgesia

Cited by 99 publications

References 39 publications

c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization

c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization

The effect of Acu-TENS on FEV1, six minute walk distance and dyspnoea in patients with chronic obstructive pulmonary disease: a randomised trial

O uso da acupuntura no auxílio à terapia da doença idiopática do trato urinário inferior dos felinos

Contact Info

Product

Resources

About