The activity of the hypothalamo-neurohypophysis during rehydration following water deprivation in the gerbil (Meriones unguiculatus) and the laboratory rat (Rattus norvegicus)

Edwards, B. A.

doi:10.1016/0300-9629(84)90228-7

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…The axons were also filled with secretory granules, as seen with electron microscopy. Both observations indicate then that the storage of HNS peptides is great in the neural lobes of both Psammomys and Gerbillus, and are in accordance with previous results [5,7,[31][32][33], demonstrating important stores of VP in the neural lobe of desert rodents, presumably necessary to allow rapid adaptation of such species to the strong dehydrating conditions of the desert environment. The AVP storage in the hypothalamus is also increased, making it possible to restore pituitary AVP pools, thereby replacing the AVP released into the blood during long-term water restriction.…”

Section: Presence Of Hns Peptides In Desert Rodents In Need Of Water ...supporting

confidence: 92%

Distribution of osmoregulatory peptides and neuronal-glial configuration in the hypothalamic magnocellular nuclei of desert rodents

Ouali-Hassenaoui

Bendjelloul

Dekar

et al. 2011

Comptes Rendus. Biologies

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Section: Presence Of Hns Peptides In Desert Rodents In Need Of Water ...supporting

confidence: 92%

Distribution of osmoregulatory peptides and neuronal-glial configuration in the hypothalamic magnocellular nuclei of desert rodents

Ouali-Hassenaoui

Bendjelloul

Dekar

et al. 2011

Comptes Rendus. Biologies

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“…Differences in ADH handling have been studied: during long times of water deprivation, the ADH depletion is smaller in the gerbil, thereby suggesting that the synthesis ability is greater (Donaldson & Edwards, 1981). In a study of the activity of the hypothalamus‐neurohypophysis during rehydration, Edwards (1984) provided further evidence of this by showing that water deprivation for 3 or 5 days resulted in the same degree of ADH depletion but that the ADH stores were replenished much faster in the gerbil. Gerbils produced small volumes of more concentrated urine even 24 h after free access to water, while the rat produced urine of similar volume and concentration as the control animals.…”

Section: Discussionmentioning

confidence: 93%

“…This leads to an increased ability to build a concentration gradient, which is needed for the formation of concentrated urine. The regulation of anti‐diuretic hormone (ADH/vasopressin) and the distribution of vasopressinergic neurons (Edwards, 1984; Wu & Shen, 1994) are other factors which differ between the species.…”

mentioning

confidence: 99%

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Göransson

Johnsson²,

Nylander

et al. 2002

The Journal of Physiology

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Our previous studies in rats have suggested a role for renomedullary hyaluronan (HA) in water homeostasis. The gerbil is known for its unique ability to conserve water. In the present study renal papillary and intestinal HA were compared between groups of anaesthetized gerbils and rats before and after up to 6 h of i.v. water loading. Baseline papillary HA in gerbils was only 37 % of that in the rat. Water loading in rats increased the papillary HA content. Elevation was maximal (+27 %, P < 0.05) after 2 h of water loading and then declined to control levels after 6 h of water loading (+3 %, n.s.). In contrast, the gerbil responded with a decreased papillary HA content during water loading. The depression was maximal after 2 h (‐49 %, P < 0.05) and was still 41 % below the control values after 6 h (P < 0.05). The urine flow rate increased rapidly in the rat and its maximum, 21 times above the control level (P < 0.05), occurred at the HA peak, i.e. after 2 h of water loading while in the gerbil, the urine flow rate increased slowly and slightly and was only six times above control values after 6 h of water loading (P < 0.05). The HA content along the intestine was similar in the two species: lowest in the duodenum and jejunum and highest in the distal colon. To conclude, in the rat, the elevation of papillary interstitial HA during acute water loading would counteract water reabsorption by changing the physico‐chemical characteristics of the interstitial matrix favouring rapid water diuresis. This would work as a complement to the powerful regulation by ADH. The gerbil has a diametrically different regulation of papillary HA turnover during water loading. The decreased papillary HA level during water loading and the slow and small diuretic response may represent a genetic difference in adaptation to enhance the ability to conserve water in an arid environment.

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“…When similar studies were conducted in gerbils, it was found that the amount of lipid droplets decreased after water loading (14). Differences in ADH handling have been studied: during long periods of water deprivation, the ADH depletion is smaller in the gerbil, thereby suggesting a greater synthesis ability (35).…”

Section: Hyaluronan During Different States Of Body Hydrationmentioning

confidence: 94%

Renal interstitial hyaluronan: functional aspects during normal and pathological conditions

Stridh

Palm

Hansell

2012

American Journal of Physiology-Regulatory, Integrative and Comp

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The glycosaminoglycan (GAG) hyaluronan (HA) is recognized as an important structural component of the extracellular matrix, but it also interacts with cells during embryonic development, wound healing, inflammation, and cancer; i.e., important features in normal and pathological conditions. The specific physicochemical properties of HA enable a unique hydration capacity, and in the last decade it was revealed that in the interstitium of the renal medulla, where the HA content is very high, it changes rapidly depending on the body hydration status while the HA content of the cortex remains unchanged at very low amounts. The kidney, which regulates fluid balance, uses HA dynamically for the regulation of whole body fluid homeostasis. Renomedullary HA elevation occurs in response to hydration and during dehydration the opposite occurs. The HA-induced alterations in the physicochemical characteristics of the interstitial space affects fluid flux; i.e., reabsorption. Antidiuretic hormone, nitric oxide, angiotensin II, and prostaglandins are classical hormones/compounds involved in renal fluid handling and are important regulators of HA turnover during variations in hydration status. One major producer of HA in the kidney is the renomedullary interstitial cell, which displays receptors and/or synthesis enzymes for the hormones mentioned above. During several kidney disease states, such as ischemia-reperfusion injury, tubulointerstitial inflammation, renal transplant rejection, diabetes, and kidney stone formation, HA is upregulated, which contributes to an abnormal phenotype. In these situations, cytokines and other growth factors are important stimulators. The immunosuppressant agent cyclosporine A is nephrotoxic and induces HA accumulation, which could be involved in graft rejection and edema formation. The use of hyaluronidase to reduce pathologically overexpressed levels of tissue HA is a potential therapeutic tool since diuretics are less efficient in removing water bound to HA in the interstitium. Although the majority of data describing the role of HA originate from animal and cell studies, the available data from humans demonstrate that an upregulation of HA also occurs in diabetic kidneys, in transplant-rejected kidneys, and during acute tubular necrosis. This review summarizes the current knowledge regarding interstitial HA in the role of regulating kidney function during normal and pathological conditions. It encompasses mechanistic insights into the background of the heterogeneous intrarenal distribution of HA; i.e., late nephrogenesis, its regulation during variations in hydration status, and its involvement during several pathological conditions. Changes in hyaluronan synthases, hyaluronidases, and binding receptor expression are discussed in parallel.

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The activity of the hypothalamo-neurohypophysis during rehydration following water deprivation in the gerbil (Meriones unguiculatus) and the laboratory rat (Rattus norvegicus)

Cited by 4 publications

References 17 publications

Distribution of osmoregulatory peptides and neuronal-glial configuration in the hypothalamic magnocellular nuclei of desert rodents

Distribution of osmoregulatory peptides and neuronal-glial configuration in the hypothalamic magnocellular nuclei of desert rodents

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Renal interstitial hyaluronan: functional aspects during normal and pathological conditions

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