The activity of silver nanoparticles (Axonnite) on clinical and environmental strains of Acinetobacter spp.

Łysakowska, Monika; Ciebiada-Adamiec, Anna; Klimek, L.; Sienkiewicz, Monika

doi:10.1016/j.burns.2014.07.014

Cited by 41 publications

(17 citation statements)

References 60 publications

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“…Similar to Łysakowska et al, the work also found that the resistant A. baumannii were less sensitive to the nanoparticle than the wild-type strains (Cavassin et al, 2015;Łysakowska et al, 2015). Further, Cavassin et al found little difference in the nanoparticle toxicity between the citrate-(highly negative ζ) and chitosan-(highly positive ζ) coated NAg particles (Cavassin et al, 2015;Łysakowska et al, 2015). Both types were equally more effective against resistant A. baumannii and other tested species when compared to the other coating type (PVA-coated; ζ potential was close to zero causing particle aggregation; El Badawy et al, 2010;Cavassin et al, 2015).…”

Section: Effect Of Nag On a Baumannii And Other Drug-resistant Bacteriasupporting

confidence: 74%

“…Cavassin et al (2015) studied NAg with various surface coatings on carbapenem and polymyxin-B-resistant A. baumannii. Similar to Łysakowska et al, the work also found that the resistant A. baumannii were less sensitive to the nanoparticle than the wild-type strains (Cavassin et al, 2015;Łysakowska et al, 2015). Further, Cavassin et al found little difference in the nanoparticle toxicity between the citrate-(highly negative ζ) and chitosan-(highly positive ζ) coated NAg particles (Cavassin et al, 2015;Łysakowska et al, 2015).…”

Section: Effect Of Nag On a Baumannii And Other Drug-resistant Bacteriasupporting

confidence: 56%

“…Each study indicated that NAg toxicity was independent of any of the antibiotic resistance traits in these bacteria, which is thought to be due to the multi-target mechanisms of the nanoparticle. Research on the activity of NAg on A. baumannii has also (mostly) shown comparable efficacy of the nanoparticle against wild-type and resistant strains (Łysakowska et al, 2015;Silva Santos et al, 2016;Chen et al, 2019a;Vila Domínguez et al, 2020). In contrast, however, Łysakowska et al (2015), when assessing NAg activity on several wild-type and MDR A. baumannii strains, found that on average, the resistant types were less sensitive [minimum inhibition concentration (MIC) = 0.78 μg/ ml] to NAg than the wild-type strains (MIC = 0.39 μg/ml).…”

Section: Effect Of Nag On a Baumannii And Other Drug-resistant Bacteriamentioning

confidence: 95%

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Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria

et al. 2021

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The misuse of antibiotics combined with a lack of newly developed ones is the main contributors to the current antibiotic resistance crisis. There is a dire need for new and alternative antibacterial options and nanotechnology could be a solution. Metal-based nanoparticles, particularly silver nanoparticles (NAg), have garnered widespread popularity due to their unique physicochemical properties and broad-spectrum antibacterial activity. Consequently, NAg has seen extensive incorporation in many types of products across the healthcare and consumer market. Despite clear evidence of the strong antibacterial efficacy of NAg, studies have raised concerns over the development of silver-resistant bacteria. Resistance to cationic silver (Ag+) has been recognised for many years, but it has recently been found that bacterial resistance to NAg is also possible. It is also understood that exposure of bacteria to toxic heavy metals like silver can induce the emergence of antibiotic resistance through the process of co-selection. Acinetobacter baumannii is a Gram-negative coccobacillus and opportunistic nosocomial bacterial pathogen. It was recently listed as the “number one” critical level priority pathogen because of the significant rise of antibiotic resistance in this species. NAg has proven bactericidal activity towards A. baumannii, even against strains that display multi-drug resistance. However, despite ample evidence of heavy metal (including silver; Ag+) resistance in this bacterium, combined with reports of heavy metal-driven co-selection of antibiotic resistance, little research has been dedicated to assessing the potential for NAg resistance development in A. baumannii. This is worrisome, as the increasingly indiscriminate use of NAg could promote the development of silver resistance in this species, like what has occurred with antibiotics.

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Section: Effect Of Nag On a Baumannii And Other Drug-resistant Bacteriasupporting

confidence: 74%

Section: Effect Of Nag On a Baumannii And Other Drug-resistant Bacteriasupporting

confidence: 56%

Section: Effect Of Nag On a Baumannii And Other Drug-resistant Bacteriamentioning

confidence: 95%

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Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria

et al. 2021

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“…Similar results were already reported for P. aeruginosa [30] and A. baumannii [31,32]. Moreover, this nanomaterial showed a similar action on the growth inhibition of multidrug-resistant bacteria presented by AgNPs synthesized by chemical and biological routes [33].…”

Section: Silver Nanocomposite Biosynthesissupporting

confidence: 87%

Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii

et al. 2016

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Abstract:Bacterial resistance is an emerging public health issue that is disseminated worldwide. Silver nanocomposite can be an alternative strategy to avoid Gram-positive and Gram-negative bacteria growth, including multidrug-resistant strains. In the present study a silver nanocomposite was synthesized, using a new green chemistry process, by the addition of silver nitrate (1.10 −3 mol·L −1 ) into a fermentative medium of Xanthomonas spp. to produce a xanthan gum polymer. Transmission electron microscopy (TEM) was used to evaluate the shape and size of the silver nanoparticles obtained. The silver ions in the nanocomposite were quantified by flame atomic absorption spectrometry (FAAS). The antibacterial activity of the nanomaterial against Escherichia coli (ATCC 22652), Enterococcus faecalis (ATCC 29282), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923) was carried out using 500 mg of silver nanocomposite. Pseudomonas aeruginosa and Acinetobacter baumannii multidrug-resistant strains, isolated from hospitalized patients were also included in the study. The biosynthesized silver nanocomposite showed spherical nanoparticles with sizes smaller than 10 nm; 1 g of nanocomposite contained 49.24 µg of silver. Multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii, and the other Gram-positive and Gram-negative bacteria tested, were sensitive to the silver nanocomposite (10-12.9 mm of inhibition zone). The biosynthesized silver nanocomposite seems to be a promising antibacterial agent for different applications, namely biomedical devices or topical wound coatings.

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“…Hospital outbreaks of Acinetobacter infections may reflect environmental contamination 24,66,[225][226][227] or carriage of A. baumannii on the hands of health care workers. 66 Aggressive infection-control measures including identifying sources of transmission, 67,225 environmental cleaning, contact precautions, and hand hygiene and isolating or cohorting infected and colonized patients 66,228 may be critical to stop or prevent outbreaks. In one study, daily chlorhexidine baths in ICU patients reduced the development VAP due to Acinetobacter.…”

Section: Preventionmentioning

confidence: 99%

Infections Due to Acinetobacter baumannii in the ICU: Treatment Options

Lynch

Zhanel

Clark

2017

Semin Respir Crit Care Med

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Bacteria within the genus (principally- complex [ABC]) are gram-negative coccobacilli that may cause nosocomial infections in critically ill or debilitated patients (particularly ventilator-associated pneumonia and infections of the bloodstream, urinary tract, and wounds). Treatment of infections is difficult, as spp. are resistant to multiple antimicrobial agents, and have a remarkable ability to via mechanisms that include plasmids, transposons, integrons, and resistance islands. Since the 1990s, global resistance to antimicrobials has escalated dramatically among ABC. Global spread of multidrug-resistant (MDR)- strains reflects dissemination of a few clones between hospitals, geographic regions, and continents; excessive use of antibiotics amplifies this spread. Many isolates are resistant to all antimicrobials except colistin (polymyxin E) and tigecycline, and some infections are untreatable with existing antimicrobial agents. Antimicrobial resistance poses a serious threat to treat or prevent infections due to ABC. Strategies to curtail environmental colonization with MDR-ABD will require aggressive infection control efforts and cohorting of infected patients. Thoughtful antibiotic strategies are essential to limit the spread of MDR-ABC. Optimal therapy will likely require combination antimicrobial therapy of existing antibiotics as well as development of novel antibiotic classes.

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The activity of silver nanoparticles (Axonnite) on clinical and environmental strains of Acinetobacter spp.

Cited by 41 publications

References 60 publications

Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria

Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria

Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii

Infections Due to Acinetobacter baumannii in the ICU: Treatment Options

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