Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii

Santos, Klebson Silva; Barbosa, Andriele Mendonça; Costa, Luiz Pereira da; Pinheiro, Malone Santos; Oliveira, M. Beatriz P.P.; Padilha, Francine Ferreira

doi:10.3390/molecules21091255

Cited by 20 publications

(8 citation statements)

References 36 publications

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“…Each study indicated that NAg toxicity was independent of any of the antibiotic resistance traits in these bacteria, which is thought to be due to the multi-target mechanisms of the nanoparticle. Research on the activity of NAg on A. baumannii has also (mostly) shown comparable efficacy of the nanoparticle against wild-type and resistant strains (Łysakowska et al, 2015;Silva Santos et al, 2016;Chen et al, 2019a;Vila Domínguez et al, 2020). In contrast, however, Łysakowska et al (2015), when assessing NAg activity on several wild-type and MDR A. baumannii strains, found that on average, the resistant types were less sensitive [minimum inhibition concentration (MIC) = 0.78 μg/ ml] to NAg than the wild-type strains (MIC = 0.39 μg/ml).…”

Section: Effect Of Nag On a Baumannii And Other Drug-resistant Bacteriamentioning

confidence: 94%

Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria

et al. 2021

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The misuse of antibiotics combined with a lack of newly developed ones is the main contributors to the current antibiotic resistance crisis. There is a dire need for new and alternative antibacterial options and nanotechnology could be a solution. Metal-based nanoparticles, particularly silver nanoparticles (NAg), have garnered widespread popularity due to their unique physicochemical properties and broad-spectrum antibacterial activity. Consequently, NAg has seen extensive incorporation in many types of products across the healthcare and consumer market. Despite clear evidence of the strong antibacterial efficacy of NAg, studies have raised concerns over the development of silver-resistant bacteria. Resistance to cationic silver (Ag+) has been recognised for many years, but it has recently been found that bacterial resistance to NAg is also possible. It is also understood that exposure of bacteria to toxic heavy metals like silver can induce the emergence of antibiotic resistance through the process of co-selection. Acinetobacter baumannii is a Gram-negative coccobacillus and opportunistic nosocomial bacterial pathogen. It was recently listed as the “number one” critical level priority pathogen because of the significant rise of antibiotic resistance in this species. NAg has proven bactericidal activity towards A. baumannii, even against strains that display multi-drug resistance. However, despite ample evidence of heavy metal (including silver; Ag+) resistance in this bacterium, combined with reports of heavy metal-driven co-selection of antibiotic resistance, little research has been dedicated to assessing the potential for NAg resistance development in A. baumannii. This is worrisome, as the increasingly indiscriminate use of NAg could promote the development of silver resistance in this species, like what has occurred with antibiotics.

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Section: Effect Of Nag On a Baumannii And Other Drug-resistant Bacteriamentioning

confidence: 94%

Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria

et al. 2021

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“…Specific secreted extracellular compounds can also be used for AgNPs synthesis. Santos et al [ 91 ] attribute the formation of AgNPs smaller than 10 nm to xanthan gum produced during the growth of Xanthomonas spp. The nanoparticles could inhibit, to a certain extent, the growth of MDR Acinetobacter baumannii and Pseudomonas aeruginosa .…”

Section: Biogenic Agnps As a Weapon Against Multidrug-resistant Bamentioning

confidence: 99%

Biogenic Nanosilver against Multidrug-Resistant Bacteria (MDRB)

et al. 2018

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Multidrug-resistant bacteria (MDRB) are extremely dangerous and bring a serious threat to health care systems as they can survive an attack from almost any drug. The bacteria’s adaptive way of living with the use of antimicrobials and antibiotics caused them to modify and prevail in hostile conditions by creating resistance to known antibiotics or their combinations. The emergence of nanomaterials as new antimicrobials introduces a new paradigm for antibiotic use in various fields. For example, silver nanoparticles (AgNPs) are the oldest nanomaterial used for bactericide and bacteriostatic purposes. However, for just a few decades these have been produced in a biogenic or bio-based fashion. This review brings the latest reports on biogenic AgNPs in the combat against MDRB. Some antimicrobial mechanisms and possible silver resistance traits acquired by bacteria are also presented. Hopefully, novel AgNPs-containing products might be designed against MDR bacterial infections.

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“…The contrast in efficiency of AgNO 3 and Ag-ZnO· m SiO 2 for G− and G+ bacteria was probably related to their different cell wall structure. Due to the more complex structure and different composition of the G− bacterial cell wall compared to G+, the nanocomposites were more adsorbed to the surface of G− and deposited in the periplasmic space [63,64]. As a result, the inhibitory effect of Ag from the nanocomposite may be lower than that induced by Ag + ions from AgNO 3 .…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Synergistic Effect Between Ag and Zn in Ag-ZnO·mSiO2 Silicate Composite with High Specific Surface Area

et al. 2019

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Antimicrobial materials are widely used for inhibition of microorganisms in the environment. It has been established that bacterial growth can be restrained by silver nanoparticles. Combining these with other antimicrobial agents, such as ZnO, may increase the antimicrobial activity and the use of carrier substrate makes the material easier to handle. In the paper, we present an antimicrobial nanocomposite based on silver nanoparticles nucleated in general silicate nanostructure ZnO·mSiO2. First, we prepared the silicate fine net nanostructure ZnO·mSiO2 with zinc content up to 30 wt% by precipitation of sodium water glass in zinc acetate solution. Silver nanoparticles were then formed within the material by photoreduction of AgNO3 on photoactive ZnO. This resulted into an Ag-ZnO·mSiO2 composite with silica gel-like morphology and the specific surface area of 250 m2/g. The composite, alongside with pure AgNO3 and clear ZnO·mSiO2, were successfully tested for antimicrobial activity on both gram-positive and gram-negative bacterial strains and yeast Candida albicans. With respect to the silver content, the minimal inhibition concentration of Ag-ZnO·mSiO2 was worse than AgNO3 only for gram-negative strains. Moreover, we found a positive synergistic antimicrobial effect between Ag and Zn agents. These properties create an efficient and easily applicable antimicrobial material in the form of powder.

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Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii

Cited by 20 publications

References 36 publications

Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria

Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria

Biogenic Nanosilver against Multidrug-Resistant Bacteria (MDRB)

Antimicrobial Synergistic Effect Between Ag and Zn in Ag-ZnO·mSiO2 Silicate Composite with High Specific Surface Area

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