The Activity of Serum 8-Iso-Prostaglandin F2&amp;lt;i&amp;gt;α&amp;lt;/i&amp;gt; as Oxidative Stress Marker in Patients with Diabetes Mellitus Type 2 and Associated Dyslipidemic Hyperglycemia

Mukhtar, Mohammed Hasan; El-Emshaty, Hoda; Al-Amodi, Hiba S.; Nasif, Wesam A.

doi:10.4236/jdm.2016.64033

Cited by 8 publications

(6 citation statements)

References 47 publications

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“…These indicators were elevated and closely correlated with unsatisfactory control of glycaemia and DM2 course severity. In most studies, 8-iso-prostaglandin F2α (8-iso-PGF2a) and 8-OHdG levels in plasma and urine were also elevated in the prediabetic stage [44,72]. These biomarkers measured in urine are considered significant in predicting micro-and macrovascular complications of DM2 [72].…”

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

2021

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The review presents modern views about the role of oxidative stress reactions in the pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the analysis of experimental and clinical studies. The sources of increased ROS generation in diabetes are specified, including the main pathways of altered glucose metabolism, oxidative damage to pancreatic β-cells, and endothelial dysfunction. The relationship between oxidative stress, carbonyl stress, and inflammation is described. The significance of oxidative stress reactions associated with hyperglycemia is considered in the context of the “metabolic memory” phenomenon. The results of our studies demonstrated significant ethnic and age-related variability of the LPO—antioxidant defense system parameters in patients with diabetes mellitus, which should be considered during complex therapy of the disease. Numerous studies of the effectiveness of antioxidants in diabetes mellitus of both types convincingly proved that antioxidants should be a part of the therapeutic process. Modern therapeutic strategies in the treatment of diabetes mellitus are aimed at developing new methods of personalized antioxidant therapy, including ROS sources targeting combined with new ways of antioxidant delivery.

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Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

2021

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“…The overproduction of reactive oxygen species (ROS) causes oxidative stress that triggers lipid peroxidation, DNA damage and protein modification, which leads to chronic inflammation, cancer and cardiovascular disorders. 15 , 16 H. pylori infection and obesity also elevates ROS production via several mechanisms. 14 , 17 ROS induces breaks, deletions and nucleoside modification in single and double-stranded DNA molecules.…”

Section: Introductionmentioning

confidence: 99%

Body mass index is associated with Helicobacter pylori infection and increased oxidative DNA damage in an obese population

et al. 2022

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Objective To determine the prevalence of Helicobacter pylori infection in a Saudi Arabian population and its association with the body mass index (BMI) and serum 8-hydroxy deoxyguanine (8-OHdG) levels as biomarker for oxidative stress. Methods This cross-sectional study enrolled patients that had experienced epigastric discomfort or dyspepsia for > 1 month and had undergone diagnostic upper endoscopy. Patients with a body mass index (BMI) ≥30 kg/m2 were defined as obese. The presence of anti- H. pylori antibodies was confirmed using an H. pylori immunoglobulin G (IgG) antibody enzyme-linked immunosorbent assay. The levels of 8-OHdG were measured using a competitive inhibition enzyme immunoassay. Results A total of 298 patients were enrolled in the study. Of these, 186 (62.4%) patients were H. pylori-positive and 112 (37.6%) patients were H. pylori-negative. The mean ± SD age of the overall study cohort was 47.17 ± 9.27 years. The H. pylori-positive patients had significantly higher levels of H. pylori IgG antibodies than H. pylori-negative patients. H. pylori prevalence linearly correlated with BMI quantile. The 8-OHdG levels were strongly associated with the BMI of the patients in the H. pylori-positive group. Conclusion Obese individuals exhibited higher H. pylori prevalence than individuals with a lean BMI (BMI < 25.00 kg/m2).

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“…However, in the work of Mohammed H. Mukhtar et al; They found IL-6 and 8-OHdG levels to be higher in DM cases compared to the control group. However, only the DM case group was studied in this study [24]. There are a limited number of studies investigating the effects of dyslipidemia in the literature, and often only DM patients have been studied.…”

Section: Discussionmentioning

confidence: 99%

Effects of lipids on inflammation and DNA damage in diabetes mellitus patients

Gulbay,

Kaya

2023

Med-Science

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We aimed to see the effect of lipids on 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of DNA damage, and Interleukin-6 (IL-6), an inflammatory cytokine, in Diabetes Mellitus (DM) patients. Serum IL-6, and 8-OHdG levels were determined using kits based on the ELISA principle. The groups were different in terms of total cholesterol, LDL cholesterol and triglyceride. Group 2 (dyslipidemia positive DM positive) was significantly higher than the other groups. There was no statistical difference between group 1 (dyslipidemia negative DM positive) and the control group (p<0.001). 8-OHdG levels differ between groups. The level of 8-OHdG was significantly higher in group 2 compared to the other groups (p<0.001). IL-6 was different between groups. Group 2, IL-6 level was found to be significantly higher than the other groups (p<0.001). A positive correlation was found between serum 8-OHdG level and total cholesterol (r=0.417 p<0.001), LDL cholesterol (r=0.491 p<0.001) and triglyceride (r=0.441 p<0.001). A positive correlation was found between IL-6 and total cholesterol (r=0.522 p<0.001), LDL cholesterol (r=0.646 p<0.001) and triglyceride (r=0.495 p<0.001). IL-6 and 8-OHdG levels are high in dyslipidemic DM patients with a high lipid profile. IL-6 and 8-OHdG levels are elevated in dyslipidemic DM patients with a high lipid profile. IL-6 and 8-OHdG can be used as biomarkers to evaluate dyslipidemic complications seen in DM patients in the early diagnosis.

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The Activity of Serum 8-Iso-Prostaglandin F2<i>α</i> as Oxidative Stress Marker in Patients with Diabetes Mellitus Type 2 and Associated Dyslipidemic Hyperglycemia

Cited by 8 publications

References 47 publications

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

Body mass index is associated with Helicobacter pylori infection and increased oxidative DNA damage in an obese population

Effects of lipids on inflammation and DNA damage in diabetes mellitus patients

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