Body mass index is associated with <i>Helicobacter pylori</i> infection and increased oxidative DNA damage in an obese population

Nasif, Wesam A.; Mukhtar, Mohammed Hasan; Ali, Abeer Shaker El-Moursy; Eldein, Mohamed Mahmoud Nour; Almaimani, Riyad A.; Ashgar, Sami S.

doi:10.1177/03000605221076975

Cited by 7 publications

(7 citation statements)

References 39 publications

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“…The prevalence of H. pylori infections at 53% in our sample of patients with obesity is comparable to the published data of an H. pylori prevalence of around 66-73% in obese patients in Saudi Arabia and higher than the known prevalence in non-obese patients, which ranges between 26% and 50% [42,43]. This indicates a possible link between obesity and H. pylori infections and could explain at least in part the increased risk of gastric cancer in obese patients [44].…”

Section: Discussionsupporting

confidence: 84%

Endoscopic Assessment Prior to Bariatric Surgery in Saudi Arabia

Aljaroudi¹,

Makki²,

Almulaify³

et al. 2023

Cureus

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Background: There are marked local inconsistencies in the Arabian Peninsula about the role of preoperative esophagogastroduodenoscopy (EGD) in bariatric surgery. Thus, this study was conducted to determine the frequency of endoscopic and histological findings in the Saudi population presenting for pre-bariatric surgery evaluation.Material and Methods: This was a retrospective study that included all the patients who were evaluated by EGD at Dammam Medical Complex, Dammam, Saudi Arabia, between 2018 and 2021 as a part of their prebariatric-surgery evaluation.Results: A total of 684 patients were included. They consisted of 250 male and 434 female patients (36.5% and 63.5%, respectively). The mean ± standard deviation for the patients' age and body mass index (BMI) were 36.4±10.6 years and 44.6±5.1 kg/m 2 , respectively. Significant endoscopic or histopathological findings as defined by the presence of large (≥ 2 cm) hiatus hernia, esophagitis, gastroesophageal reflux disease (GERD), Barrett esophagus, gastric ulcer, duodenal ulcer, or intestinal metaplasia were found in 143 patients (20.9%); 364 patients (53.2%) were diagnosed to have Helicobacter pylori infection. Conclusion:The high number of significant endoscopic and histopathological findings in our study supports the routine use of preoperative EGD in all bariatric surgery patients. However, omitting EGD before Rouxen-Y gastric bypass (RYGB) in asymptomatic patients is still reasonable as the most frequently found significant findings, esophagitis, and hiatus hernia, are less likely to impact the operative plans in RYGB. Similarly, active surveillance and treatment of H. pylori infections in obese patients are important but it is not clear whether H. pylori eradication should be done before bariatric surgery.

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Section: Discussionsupporting

confidence: 84%

Endoscopic Assessment Prior to Bariatric Surgery in Saudi Arabia

Aljaroudi¹,

Makki²,

Almulaify³

et al. 2023

Cureus

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“…8 However, there is another study that shows a positive linear correlation between nutritional status (BMI) and the incidence of H. pylori infection (p 0.0001), where the risk of H. pylori infection is greater in overweight patients. 16 In this study, there was no association between smoking and the incidence of H. pylori infection (p 0.181). Although included in the regression test (p < 0.25), the final analysis results showed no significant OR value.…”

Section: Discussioncontrasting

confidence: 47%

Risk Factors of Helicobacter Pylori Infection in Samosir Island

Mutia,

Masrul,

Imelda

2023

Int J Res Rev

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Introduction. Helicobacter pylori infection mostly associated with gastrointestinal disease such as gastritis, peptic ulcer, duodenal ulcer, and gastric adenocarcinoma. Route of transmission of H. pylori are not fully understood, but human-to-human transmission via oral-oral or fecal-oral route is considered the most likely route. Prevalence of this bacterial infection also varies between countries, Indonesia itself has a fairly low prevalence of H. pylori infection at rate of 22.1%. This study aims to determine the prevalence and risk factors of H. pylori infection among Batak ethnicity in Samosir Island. Method. A cross-sectional study was conducted from March – May 2021 to determine the prevalence and risk factors of H. pylori infections in Samosir Island through stool antigen test (SAT) examination. Results. A total of 100 patients reside in Boho Village, Samosir Island enrolled in this study. All of the subjects were tested for H. pylori infection with SAT. The study also collected data using the questionnaire method, and obtained data on age, gender, occupation, education level, history of smoking and alcohol consumption, nutritional status, and also H. pylori diagnostic test results. Conclusion. Prevalence of H. pylori infection in Samosir Island based on SAT is 18% with the risk factors that are significantly associated with environmental sanitation (p=0.001) and personal hygiene (p=0.004). Keywords: H. pylori, Batak Ethnicity, Stool Antigen Test

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“…[12] Similarly, a cross-sectional study showed that the prevalence of H. pylori infection in obese individuals was higher than that in individuals with low BMI (BMI < 25 kg/m 2 ). [13] A recent meta-analysis showed that the risk of H. pylori infection was positively correlated with the prevalence of obesity. [14] According to the existing evidence, the relationship between H. pylori infection and obesity may involve several mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Status, Obesity, and Helicobacter pylori infection: a cross-sectional study in US adults from NHANES 1999-2000

Chen,

Wang,

Yang

et al. 2023

Preprint

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Objective Recent studies on the association between Helicobacter pylori (H. pylori) infection and obesity have reported conflicting results. Therefore, the purpose of our study was to investigate the association of metabolic status and obesity with H.pylori infection. Methods A cross-sectional study of 1568 participants aged 20–85 years was conducted using the NHANES cycle 1999–2000. We used different anthropometric criteria to evaluate the association between general obesity, abdominal obesity, and H. pylori infection. Results After grouping individuals according to their body mass index and waist circumference, among subjects aged ≤ 50 years, the OR (95% CI) for subjects with a waist-height ratio of ≥ 0.5 in Model 1 was 1.87 (1.35–2.58) compared with the control group. This finding was still statistically significant in Models 2, 3, and 4, with ORs (95% CI) of 1.47 (0.99–2.18), 1.67 (1.16–2.41), and 2.23 (1.24–4.01), respectively. In Model 1, subjects older than 50 years old had an OR (95% CI) for metabolically healthy obesity of 0.09 (0.01–0.69), compared with the control group; after adjustment for major covariates, their ORs (95% CI) were 0.05 (0.00–2.87), 0.04 (0.01–0.35), and 0.04 (0.01–0.35) in Models 2, 3, and 4, respectively. Conclusions Abdominal obesity, as defined by the WHtR, was associated with H. pylori infection in subjects aged ≤ 50 years.

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Body mass index is associated with Helicobacter pylori infection and increased oxidative DNA damage in an obese population

Cited by 7 publications

References 39 publications

Endoscopic Assessment Prior to Bariatric Surgery in Saudi Arabia

Endoscopic Assessment Prior to Bariatric Surgery in Saudi Arabia

Risk Factors of Helicobacter Pylori Infection in Samosir Island

Metabolic Status, Obesity, and Helicobacter pylori infection: a cross-sectional study in US adults from NHANES 1999-2000

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