The active compounds of Passiflora spp and their potential medicinal uses from both in vitro and in vivo evidences

Smruthi, R; Divya, M.; Archana, K.; Ravi, Maddaly

doi:10.21608/jabps.2020.44321.1105

Cited by 2 publications

(2 citation statements)

References 28 publications

(30 reference statements)

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“…From among the polyphenols in the present study, quercetin, terpene, and kaempferol of flavonoids and turmerones, saponin, gallic acid, and frolic acid of phenolic acids, more than their other groups, were observed in the compounds used for drug intervention [70,[72][73][74][75][76][77][78][79][80]. Although the main isoforms of polyphenolic molecules are different in each plant, all these forms have relatively similar functions in the human body, all causing reduced inflammation and mucus and relaxation of smooth muscle [35,48,53,56,57,62,81].…”

Section: Discussionmentioning

confidence: 54%

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Efficacy of Herbal Medicines on Lung Function in Asthma: a systematic review and meta-analysis of randomized controlled trials

et al. 2023

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Objectives: The present study was designed to conduct a comprehensive systematic review and meta-analysis to assess the efficacy of herbal medicines as add-on therapy on lung function in asthmatic patients. Methods: A comprehensive search of online databases was performed up to December 2021 to identify randomized controlled trials that used orally herbal preparations for asthma as add-on therapy. Studies were assessed for methodological quality using the Cochrane Collaboration's Risk of Bias tool. The main outcome was percent predicted value of forced expiratory volume (% predicted FEV1). Pooled weighted mean difference (WMD) estimate with corresponding 95% confidence interval (CI) was calculated using inversevariance weights method while random effects meta-analysis was used, taking into account clinical and conceptual heterogeneity. Results: As a result, 1,525 studies were identified. 169 studies were reviewed in-depth and 23 studies met our systematic review inclusion criteria. Finally, nine randomized controlled trials were included in the meta-analysis. Findings indicated that use of herbal medicines in patients with asthma significantly improved % predicted FEV1 (WMD: 3.73, 95% CI: 1.76-5.70), with no evidence for significant heterogeneity (p = 0.56 [Q statistic], I 2 = 0.0%). In subgroup analysis by age, improvement in % predicted FEV1 was higher and significant in adults (WMD: 5.16; 95% CI: 2.68-7.63) compared to children (WMD = 1.27; 95% CI: −1.98-4.51). Sensitivity analysis showed the significant effect of herbal medicine consumption on improving FEV1 was consistently (range of summary WMDs: 3.27-4.59), indicating that the meta-analysis model was robust. There was no evidence of publication bias both visually and statistically. Conclusion: Findings support, the complementary use of herbal medicines resulted in significant improvement in the lung function compared to standard treatment in asthmatic patients with no considerable adverse events. This improvement is more likely to be observed amongst adults.

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Section: Discussionmentioning

confidence: 54%

“…Different classes of polyphenols, including anthocyanin, have strong protective effects on pulmonary function parameters. Polyphenols inhibit the induced expression of nitric oxide synthase and prevent oxidative and nitric oxidative damage to the lung [70][71][72].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Herbal Medicines on Lung Function in Asthma: a systematic review and meta-analysis of randomized controlled trials

et al. 2023

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Medicinal Plants for Glioblastoma Treatment

Datta

Luthra

Bharadvaja

2022

ACAMC

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: Glioblastoma, an aggressive brain cancer, demonstrates the least life expectancy among all brain cancers. Because of the regulation of diverse signaling pathways in cancers, the chemotherapeutic approaches used to suppress their multiplication and spreading are restricted. Sensitivity towards chemotherapeutic agents has developed because of the pathological and drug-evading abilities of these diverse mechanisms. As a result, the identification and exploration of strategies or treatments, which can overcome such refractory obstacles to improve glioblastoma response to treatment as well as recovery, is essential. Medicinal herbs contain a wide variety of bioactive compounds, which could trigger aggressive brain cancers, regulate their anti-cancer mechanisms and immune responses to assist in cancer elimination, and cause cell death. Numerous tumor-causing proteins, which facilitate invasion as well as metastasis of cancer, tolerance of chemotherapies, and angiogenesis, are also inhibited by these phytochemicals. Such herbs remain valuable for glioblastoma prevention and its incidence by effectively being used as anti-glioma therapies. This review thus presents the latest findings on medicinal plants using which the extracts or bioactive components are being used against glioblastoma, their mechanism of functioning, pharmacological description as well as recent clinical studies conducted on them.

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The active compounds of Passiflora spp and their potential medicinal uses from both in vitro and in vivo evidences

Cited by 2 publications

References 28 publications

Efficacy of Herbal Medicines on Lung Function in Asthma: a systematic review and meta-analysis of randomized controlled trials

Efficacy of Herbal Medicines on Lung Function in Asthma: a systematic review and meta-analysis of randomized controlled trials

Medicinal Plants for Glioblastoma Treatment

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