The Activatory Effect of Low Incident Energy He-Ne Laser Radiation on Hydroxyapatite Implants in Rabbit Mandibular Bone

Asanami, Soichiro; Shiba, Hideyuki; Ohtaishi, Masatsugu; Okada, Yutaka; Ohsaka, Fumihiro; Tanaka, Yoïchi

doi:10.5978/islsm.93-or-02

Cited by 11 publications

(20 citation statements)

References 5 publications

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“…The results of the control groups with regards to the biochemical processes that occur at a new bone formation process in rats were similar to Reddi and Huggins (18) and Reddi (19). The uniqueness of the present study was that the objective biochemical data supported the histological and clinical observations previously reported (1–5, 7–13).…”

Section: Discussionsupporting

confidence: 87%

“…In clinical and experimental studies, the photobiological and photochemical effects of low intensity lasers have shown that low‐energy irradiation of injured tissues improves wound healing by accelerated epithelization, high degree of vascularization, increased collagen synthesis and stimulated fibroblast activity (1–3, 7–13). Clinically, beneficial effects of low intensity laser irradiation have been reported in the treatment of pain (6, 20) and in increasing bone formation (4, 13–15). The basic biochemical mechanism behind low energy lasers, however, has not been elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Scientific findings indicate good healing of soft tissue, faster regeneration of severed nerves (8), increasing formation of new capillaries through the release of growth factors (9), stimulation of DNA and RNA synthesis formation in the cell nucleus (10), transformation of fibroblasts to myofibroblasts (11) and biostimulation of bone marrow cells (12). Lasing also results in new bone formation around hydroxyapatite implants in rabbits and a significant increase in the total bone area (13). In hard tissues, low‐power laser irradiations significantly increased the number of viable osteocytes in the irradiated bone by a positive effect on bone matrix production to produce highly reactive and vital peri‐implant bone tissue (14).…”

Section: Introductionmentioning

confidence: 99%

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Effect of low intensity laser irradiation on surgically created bony defects in rats

Nissan

Assif

Groß

et al. 2006

J of Oral Rehabilitation

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Low intensity lasers have been used by clinicians to improve healing and reduce pain in humans. Lasing also results in new bone formation around hydroxyapatite implants and a significant increase in the total bone area. However, the exact mechanism of cell biostimulation by laser is still unclear. This study biochemically assessed the effects of low intensity laser (Gallium-Arsenide) using 4 and 22.4 mW cm(-2) power density on the bone healing process after surgically creating bony cavities in rat mandibles. Rats (n = 24) were divided into two groups each treated with specific energy, 4 or 22.4 mW cm(-2), for 3 min each day post-surgery. Surgical cavities were created on both sides of the mandible: the left served as an untreated control, the right was treated with laser. All rats were sacrificed after 1, 2 and 4 weeks of treatment. In the newly formed callus, accumulation of radiocalcium and alkaline phosphatase activity was measured to indicate osteogenic activity. One-way anova with repeated measures showed that the low intensity laser using 4 mW cm(-2) power density significantly increased radiocalcium accumulation from 2 weeks post-surgery, whereas 22.4 mW cm(-2) had no effect. No changes were noted in the activity of alkaline phosphatase with the laser treatment. These results suggest that laser therapy of low power density is effective on the bone healing process in artificially created osseous cavities by affecting calcium transport during new bone formation.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of low intensity laser irradiation on surgically created bony defects in rats

Nissan

Assif

Groß

et al. 2006

J of Oral Rehabilitation

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“…However, to the present authors' knowledge and according to Tunér & Hode (1999), very few studies exist on LPL postimplantation therapy (Kusakari et al 1992; Asanami et al 1993), although there are some other physical stimuli that are increasingly being considered as ‘combination’ or ‘adjuvant’ therapies to enhance bone attachment to the material surface (Matsumoto et al 2000; Shigino et al 2000; Tanzer et al 2001; Fini et al 2002; Ottani et al 2002). Bone attachment stimulating factors could be used by orthopaedists and dentists when negative factors predictive of poor osseointegration are identified, for example in the case of poor bone stock at the implant site (LeGeros & Craig 1993).…”

mentioning

confidence: 99%

Osseointegration of endosseous ceramic implants after postoperative low‐power laser stimulation: an in vivo comparative study

Guzzardella

Torricelli

Nicoli-Aldini

et al. 2003

Clinical Oral Implants Res

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Stimulation with low-power laser (LPL) can enhance bone repair as reported in experimental studies on bone defects and fracture healing. Little data exist concerning the use of LPL postoperative stimulation to improve osseointegration of endosseous implants in orthopaedic and dental surgery. An in vivo model was used for the present study to evaluate whether Ga-Al-As (780 nm) LPL stimulation can improve biomaterial osseointegration. After drilling holes, cylindrical implants of hydroxyapatite (HA) were placed into both distal femurs of 12 rabbits. From postoperative day 1 and for 5 consecutive days, the left femurs of all rabbits were submitted to LPL treatment (LPL group) with the following parameters: 300 J/cm2, 1 W, 300 Hz, pulsating emission, 10 min. The right femurs were sham-treated (control group). Three and 6 weeks after implantation, histomorphometric and microhardness measurements were taken. A higher affinity index was observed at the HA-bone interface in the LPL group at 3 (P<0.0005) and 6 weeks (P<0.001); a significant difference in bone microhardness was seen in the LPL group vs. the control group (P<0.01). These results suggest that LPL postoperative treatment enhances the bone-implant interface.

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“…There have been reports on the effect of LLLT in pain attenuation [1,2], wound healing [3], bone remodeling [4], skin rejuvenation [5,6], treatment of skin inflammatory diseases [7,8], and so on. LLLT is performed with red-beam or near-infrared lasers having a wavelength of 600-1100 nm, output power of 1-500 mW, and low-energy density of 0.04-50 J/cm 2 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Low-Level Laser Therapy on Human Adipose-Derived Stem Cells: In Vitro and In Vivo Studies

et al. 2015

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This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266 .

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The Activatory Effect of Low Incident Energy He-Ne Laser Radiation on Hydroxyapatite Implants in Rabbit Mandibular Bone

Cited by 11 publications

References 5 publications

Effect of low intensity laser irradiation on surgically created bony defects in rats

Effect of low intensity laser irradiation on surgically created bony defects in rats

Osseointegration of endosseous ceramic implants after postoperative low‐power laser stimulation: an in vivo comparative study

Effect of Low-Level Laser Therapy on Human Adipose-Derived Stem Cells: In Vitro and In Vivo Studies

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