The Action of Topical Basic Fibroblast Growth Factor in Facial Nerve Regeneration

Toledo, Ronaldo Nunes; Borin, Andrei; Cruz, Oswaldo Laércio Mendonça; Ho, Paulo Lee; Testa, José Ricardo Gurgel; Fukuda, Yotaka

doi:10.1097/mao.0b013e3181c0e7e9

Cited by 13 publications

(4 citation statements)

References 37 publications

(48 reference statements)

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“…In previous studies inducing facial nerve injury, complete functional recovery was reported to occur between days 9 and 21 in the groups with nerve injury . Similar results were obtained in this study, and functional recovery was accelerated in the IG + Res as compared to the other subgroups.…”

Section: Discussionsupporting

confidence: 91%

The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study

et al. 2015

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Section: Discussionsupporting

confidence: 91%

The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study

et al. 2015

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“…The small size of these animals and their phylogenetic distance from human beings may explain this phenomenon, also observed in our previous studies [6][7][8].…”

Section: Introductionsupporting

confidence: 83%

Experimental model of facial paralysis by nerve compression in primates (Callithrix sp.): A new model of facial paralysis in small nonhuman primates

Neiva¹,

Borin²,

Cinini

et al. 2012

Acta Oto-Laryngologica

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“…FGF family members bind heparin and possess broad mitogenic and angiogenic activities (24). bFGF has been implicated in diverse biological processes, such as limb and nervous system development (25), wound healing (26) and tumor growth (27). A previous study in an animal model demonstrated that bFGF was important in continuous hemodynamic-overload stimulation-induced myocardial cell hypertrophy, myocardial fibrosis and myocardial collagen hyperplasia (28).…”

Section: Discussionmentioning

confidence: 99%

Hepatocyte growth factor and basic fibroblast growth factor regulate atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease via the mitogen-activated protein kinase signaling pathway

et al. 2013

Experimental and Therapeutic Medicine

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The aim of this study was to investigate the interrelation between basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF) and atrial fibrosis in patients with atrial fibrillation (AF) and rheumatic heart disease (RHD), and to explore the possible molecular mechanisms underlying this interrelation. Twenty patients with RHD who were scheduled for valve replacement were divided into two groups, comprising 10 cases with AF and 10 cases with sinus rhythm (SR). Clinical data were collected and a small sample of aseptic left atrial appendage was collected by the surgeon. Hematoxylin and eosin (H&E) and Masson’s trichrome-stained sections were used to evaluate the cross-sectional area and level of fibrosis, respectively. The expression levels of bFGF and HGF were assessed using immunohistochemistry. The phosphorylation levels of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 (MEK1/2), c-Jun N-terminal kinase 1/2 (JNK1/2), extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 in atrial tissue were measured using western blotting. Compared with the SR group, myocardial cell diameter was significantly expanded and there was increased collagen deposition in the AF group (P<0.05). The distribution of bFGF in the AF group was significantly higher than that in the SR group (P<0.05); however, HGF levels were significantly lower in the AF group (P<0.05). The phosphorylation levels of MEK1/2, ERK1/2, JNK1/2 and p38 in the AF group were significantly higher than those in the SR group (P<0.05). The results indicated that bFGF may promote the development of atrial fibrosis, while HGF may function in an opposite manner in patients with AF and RHD. The mitogen-activated protein kinase (MAPK) signaling pathway may be the molecular basis for these roles in atrial fibrosis.

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The Action of Topical Basic Fibroblast Growth Factor in Facial Nerve Regeneration

Abstract: This study showed that the regeneration of the facial nerve occurred earlier and resulted in significantly more myelinated nerve fibers in the animals that received topical bFGF.

Cited by 13 publications

References 37 publications

The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study

The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study

Experimental model of facial paralysis by nerve compression in primates (Callithrix sp.): A new model of facial paralysis in small nonhuman primates

Hepatocyte growth factor and basic fibroblast growth factor regulate atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease via the mitogen-activated protein kinase signaling pathway

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