The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study

Abstract

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Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury

“…We found Res improved motor function at a dose of both 200 and 50 mg/kg, but the higher dose led to better motor repair than the lower dose. Although the doses of Res we used were higher than those used previously to alleviate the peripheral nerve injury-induced motor deficit, we obtained the motor repair within a period of treatment much shorter than before (Bagriyanik et al, 2014 ; Tanyeri et al, 2015 ). For example, in a study performed by Tanyeri et al, it took 2 weeks to observe motor recovery after i.p.…”

“…For example, in a study performed by Tanyeri et al, it took 2 weeks to observe motor recovery after i.p. treatment with 30 mg/kg Res in a rat model of facial nerve crush injury (Tanyeri et al, 2015 ). In another study, Bagriyanik et al found that motor amelioration was identified 2 weeks after i.p.…”

Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health‐Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action

“…Usually, one given compound is assayed for one disease or for two/three closely related diseases. In the case of RSV, results from clinical trials have been reported for menopause (Chow et al., ; Evans, Howe, & Wong, ; Yoshino et al., ; Zern et al., ) and for an incredibly high number of ailments: ulcerative colitis (Samsami‐kor, Daryani, Asl, & Hekmatdoost, ), lung affections/infections (Culpitt et al., ; Miraglia Del Giudice et al., ; Varricchio et al., ), allergic rhinitis (Miraglia Del Giudice et al., ), liver diseases (Chachay et al., ; Faghihzadeh, Adibi, & Hekmatdoost, ; Faghihzadeh, Adibi, Rafiei, & Hekmatdoost, ; Heebøll et al., ), chronic kidney disease (Migliori et al., ), benign prostate hyperplasia (Kjaer et al., ), schizophrenia (Zortea et al., ), memory performance/cognition/brain glucose consumption/AD (Cuzzola et al., ; Kennedy et al., ; Turner et al., ; Wightman et al., ; Witte, Kerti, Margulies, & Flöel, ), Friedreich ataxia (Yiu et al., ), facial nerve injury (Tanyeri, Celik, Erbas, Oltulu, & Yilmaz Dilsiz, ), diabetes/metabolic syndrome/insulin resistance (Bhatt, Thomas, & Nanjan, ; Brasnyó et al., ; Chen et al., ; Crandall et al., ; Fujitaka et al., ; Goh et al., ; Méndez‐del Villar, González‐Ortiz, Martínez‐Abundis, Pérez‐Rubio, & Lizárraga‐Valdez, ; Olesen et al., ; Skroza et al., ; Thazhath et al., ; Tomé‐Carneiro et al., ), inflammation (Olesen et al., ), facial redness (Ferzli, Patel, Phrsai, & Brody, ), cancer/metastases (Brown et al., ; Chow et al., ; Howells et al., ; Ji et al., ; Patel et al., ; Popat et al., ), cardiovascular diseases/lipoprotein status/obesity (Agarwal et al., ; Amato et al., ; Bakker et al., ; Biesinger et al., ; Cruz, ; Dash, Xiao, Morgantini, Szeto, & Lewis, ; De Groote et al., …”

Intraoperative Corticosteroids for Voice Outcomes among Patients Undergoing Thyroidectomy: A Systematic Review and Meta‐analysis

“…16,17 In traumatic facial nerve injuries, topical and systemic steroids were both shown to accelerate recovery in rodent models. 18,19 The administration of methylprednisone within 24 hours after traumatic optic neuropathy was also associated with improved visual acuity. 20 Conversely, numerous studies showed corticosteroids to be ineffective in preventing neuronal injury or in hastening recovery among patients undergoing parotidectomy.…”