1978
DOI: 10.2170/jjphysiol.28.757
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The Action of N-Ethylmaleimide on the Membrane Currents and Contractile Tension in the Bullfrog Atrium

Abstract: The effects of N-ethylmaleimide (NEM), a sulfhydryl blocking reagent, on the membrane currents, action potentials and contractile tension in bullfrog atrial muscle were studied by using the double sucrose gap technique. In concentrations of 10-3 to 10-4 M, NEM led to a transient enhancement of twitch contraction followed by a late inhibition, while 10-2 M NEM merely produced an inhibitory effect. The positive inotropism was accompanied by a prolongation of action potential and the negative inotropism, by a dep… Show more

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Cited by 6 publications
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“…Preparation and the experimental conditions were the same as reported previously (AoMINE and ABE, 1978a Burk plots of the data also supported the above view (Fig. 2B).…”
Section: Methodssupporting
confidence: 82%
“…Preparation and the experimental conditions were the same as reported previously (AoMINE and ABE, 1978a Burk plots of the data also supported the above view (Fig. 2B).…”
Section: Methodssupporting
confidence: 82%