The Action of Morphine, Pethidine, and Amidone Upon the Intestinal Motility of Conscious Dogs

The intraluminal pressure patterns in diverticulosis of the colon: Part IV The effect of pethidine and probanthine

“…Its effect therefore suggests that morphine may act through the autonomic nervous system to initiate the pressure changes that follow its administration. This supports the suggestion of Vaughan Williams and Streeten (1950) that a central mechanism is involved when morphine acts in vivo. When studying fluid propulsion in the dog's small intestine, these investigators found that larger doses of the drug were required in vitro to produce the effects observed in vivo.…”

Gastrointestinal myoelectric activity following abdominal operations in the opossum

“…The role of analgesics and anesthetics in the development of postoperative ileus needs to be evaluated. Morphine has been demonstrated to cause constipation, delayed gastric emptying, and a prolonged depression of intestinal propulsion [18]. Bueno et al reported no important change in the intestinal myoelectric activity of rats during anesthesia with ethyl ether, pentobarbital, or thiopental [13].…”

The intraluminal pressure patterns in diverticulosis of the colon: Part II The effect of morphine

“…Much conflicting evidence has accumulated over the past 70 years regarding its effect on the intestine. Vaughan Williams andStreeten (1950, 1951) have pointed out that the opposing views of previous investigators are largely the result of the limitations of the techniques they employed, and that many of the differing conclusions that have been expressed can be reconciled when this fact is appreciated. Nevertheless, even though its mode of action and, in particular, its effect on the human intestine, are so little understood, the drug is very widely used.…”