The action of extracellular cations on the release of the sympathetic transmitter from peripheral nerves

Cation and Metabolic Requirements for Retention of Metaraminol by Rat Uterine Horns

“…Thus Ca++ has been claimed to have no effect on the retention of amines by perfused rat heart (Iversen & Kravitz, 1966) perfused cat spleen (Kirpekar & Misu, 1967) and isolated rat uterine horns (Green & Miller, 1966a;present study) whereas Ca+ + was needed for optimal retention of amines by heart slices (Dengler, 1965;Gillis & Paton, 1966 and guinea-pig uterus (Boullin, 1967). These differences may reflect variations in the amount of bound Ca++ remaining and/or in the degree of increased permeability produced by the absence of Ca++ (Hays, Singer & Malamed, 1965).…”

Release of noradrenaline from the cat spleen by sodium deprivation

“…Evoked release of noradrenaline is calcium-dependent (Hukovic & Muscholl, 1962;Burn & Gibbons, 1965;Kirpekar & Misu, 1967;Boullin, 1967), whereas noradrenaline release induced by sodium deprivation appears to be calcium-independent. Incubation of splenic slices in sodium-and calcium-free solution containing EGTA caused loss of noradrenaline at the same rate as that from slices incubated in sodium-free Krebs solution alone.…”

Brain and Serum Calcium Concentrations Following Electroconvulsive Shock or Bicuculline‐induced Convulsions in Rats

“…Since calcium is known to be intimately involved in the regulation of release of neurotransmitters including the monoamines (for example, Boullin, 1967;Stjarne, 1973 Bicuculline (Sigma, Poole), diazepam (Roche) and 0.9% w/v NaCl solution (saline) were injected intravenously via a tail vein.…”