1975
DOI: 10.1111/j.1476-5381.1975.tb07346.x
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The ACTION OF AMINOPHYLLINE ON THE ACUTELY TRANSPLANTED DOG HEART: EFFECT OF Α‐ AND Β‐ADRENOCEPTOR BLOCKADE

Abstract: I Aminophylline inhibits the coronary vasodilator actions of adenosine. Our previous studies suggested that low dose infusions of aminophylline reduce coronary blood flow in the isolated heart. In the present study we investigated the actions of aminophylline on coronary blood flow and myocardial contractility in a transplanted heart model. Drugs were given by close coronary arterial infusion.2 Aminophylline in low doses (200 pg/min) reduced coronary blood flow by 21 ± 2% (mean ± s.e. mean) but did not alter m… Show more

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Cited by 7 publications
(2 citation statements)
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“…The positive inotropic effects of the drug have been clearly demonstrated in isolated atrial2" 22 and papillary muscle23-25 and also in the isolated heart26' 27 and in anesthetized dog preparations.' 28 Aminophylline reduces the left ventricular filling pressure in patients with and without heart disease, '20, 23, 29-3 findings compatible with those in the present study in which LV end-diastolic diameter fell.…”
Section: Discussionsupporting
confidence: 83%
“…The positive inotropic effects of the drug have been clearly demonstrated in isolated atrial2" 22 and papillary muscle23-25 and also in the isolated heart26' 27 and in anesthetized dog preparations.' 28 Aminophylline reduces the left ventricular filling pressure in patients with and without heart disease, '20, 23, 29-3 findings compatible with those in the present study in which LV end-diastolic diameter fell.…”
Section: Discussionsupporting
confidence: 83%
“…The frequency response of the left ventricular recording system was flat ± 5% to 35 Hz using a sine wave pressure generator. 10 Recordings were made at fast paper speed (200 mm/sec) for accurate analysis.…”
Section: Experimental Modelmentioning
confidence: 99%