The acetylcholinesterase-inhibitory activity of steroidal glycoalkaloids and their aglycones

Roddick, James G.

doi:10.1016/s0031-9422(00)98055-5

Cited by 125 publications

(87 citation statements)

References 13 publications

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“…have never been reported before and their inhibitory AChE activities could be attributed to their high alkaloidal contents (see Table); this correlates with the statement established by Roddick (1989), since their AChE inhibitory activity, could be due to the presence of steroidal glycoalkaloids, which are characteristic to the Solanaceae family.…”

Section: Resultssupporting

confidence: 82%

“…In addition, according to Roddick (1989), the inhibitory effects of the steroidal glycoalkaloids α-solanine and α-chaconine on human AChE, showed that both alkaloids were equally active and no synergism occurred between the two compounds. On the other hand, α-solanine and α-chaconine, displayed stronger AChE inhibitory activity than the glycoalkaloids solasonine and solamargine, although they share the same trioside carbohydrate moieties.…”

Section: Resultsmentioning

confidence: 99%

“…Among the plant families that have been examined for their AChE inhibitory activity are: Amaryllidaceae (Houghton et al 2004, Rhee et al 2004, Boraginaceae (Ahmad et al 2003b), Chenopodiaceae (Ferheen et al 2005), Lamiaceae (Ahmad et al 2005), Liliaceae (Atta-urRahman et al 2002), and Solanaceae (Roddick 1989.…”

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confidence: 99%

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In vitro inhibition of acetylcholinesterase by crude plant extracts from Colombian flora

Niño

Hernández

Correa

et al. 2006

Mem. Inst. Oswaldo Cruz

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The methanol extracts from five different plant families (Asteraceae, Euphorbiaceae, Melastomataceae, Rubiaceae, and Solanaceae) collected at Regional Natural Park Ucumarí (Colombia), were screened for their acetylcholinesterase inhibitory activity through the modified Ellman's spectrophotometric method. The best inhibitory activities on this study were shown by the extracts of Solanum leucocarpum Dunal (IC 50 = 204.59 mg/l) and Witheringia coccoloboides (Damm) (IC 50 = 220.68 mg/l), both plants belonging to the Solanaceae family.Key words: acetylcholinesterase (AChE) inhibitors -Asteraceae -Euphorbiaceae -Melastomataceae -Rubiaceae -SolanaceaeThe acetylcholinesterase enzyme (AChE) is an attractive target for the rational drug design and for the discovery of mechanism based inhibitors because of its role in the hydrolysis of the neurotransmitter acetylcholine (ACh). AChE inhibitors are the most effective approach to treat the cognitive symptoms of Alzheimer disease (AD) (Kalauni et al. 2002) and other possible therapeutic applications in the treatment of Parkinson's disease, senile dementia, and ataxia, among others (Ahmad et al. 2003a). AChE inhibitors as eserine, tacrine, donepezil, rivastigmine, and galanthamine are the only drugs currently approved for the treatment of AD; however, these drugs are known to have limitations for clinical use due to their short-half-lives and/or unfavorable side-effects (Sung et al. 2002).Because the search of plant extracts that selectively inhibit AChE is of paramount importance to find novel and more potent AChE inhibitors, many of them have been screened and as consequence there have been found extracts and isolated pure compounds with AChE and/or butyrylcholinesterase (BChE) inhibitory properties. Among the plant families that have been examined for their AChE inhibitory activity are: Amaryllidaceae Continuing with the study of the flora from Regional Natural Park Ucumarí (RNPU, Risaralda, Colombia) as a source of new secondary metabolites with diverse grade of biological activities (Niño et al. 2003, 2006, Mosquera et al. 2004a) and the fact that there still is great interest in finding novel and better AChE inhibitors, prompted us to screen 27 crude methanol extracts belonging to the Asteraceae, Euphorbiaceae, Melastomataceae, Rubiaceae, and Solananceae families for their AChE inhibitory activities. MATERIALS AND METHODSIn this study, the solvent hexanes, dichloromethane, and methanol (analytical-reagent grade) were purchased from Mallinckrodt (Phillipsburg, NJ, US). Silica gel plates (Silica gel 60 F 254 0.2 mm layer thickness) were purchased from Merck (Darmstadt, Germany). The electric eel acetylcholinesterase Sigma (St Louis, MO, US) was used. Acetylthiocholine iodide and 5,5-dithiobis (2-nitro benzoic acid) (DTNB) were purchased from Aldrich (St Louis, MO, US). A Spectronic Genesys 5 spectrophotometer Milton Roy (Rochester, NY, US) was used for all measurements of acetylcholinesterase inhibitory activity.Plant material -Twenty seven plants from the selected famili...

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

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In vitro inhibition of acetylcholinesterase by crude plant extracts from Colombian flora

Niño

Hernández

Correa

et al. 2006

Mem. Inst. Oswaldo Cruz

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“…Positive synergistic effects have been observed for chaconine and solanine in permeation of liposomes (Roddick & Rijnenberg, 1986), disrupting membranes (Keukens et al, 1995), antifungal (Fewell & Roddick, 1993) and antitumorigenic effects (Friedman et al, 2005). However, combinations of chaconine and solanine were slightly antagonistic or non-interactive in acetylcholinesterase inhibition (Roddick, 1989). In our study, co-administration of chaconine and solanine did not act synergistically to suppress Plasmodium yoelii parasitemia in mice.…”

Section: Discussioncontrasting

confidence: 47%

In vivoantimalarial activities of glycoalkaloids isolated from Solanaceae plants

Chen¹,

Li²,

Sun³

et al. 2010

Pharmaceutical Biology

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“…3) In recent times, the mixtures of solasodine glycosides have been used successfully for the treatment of certain human skin carcinomas. 4) The plant cell and tissue culture techniques have been used to produce secondary metabolites over the last 50 years.…”

mentioning

confidence: 99%

Salinity Stress Enhances Production of Solasodine in Solanum nigrum L.

et al. 2008

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The acetylcholinesterase-inhibitory activity of steroidal glycoalkaloids and their aglycones

Cited by 125 publications

References 13 publications

In vitro inhibition of acetylcholinesterase by crude plant extracts from Colombian flora

In vitro inhibition of acetylcholinesterase by crude plant extracts from Colombian flora

In vivoantimalarial activities of glycoalkaloids isolated from Solanaceae plants

Salinity Stress Enhances Production of Solasodine in Solanum nigrum L.

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